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| 1 | A prospective longitudinal study for latent tuberculosis infection in hospital in Beijing evaluating a T-cell-based assay health-care workers in a general显示文摘 | ZHANG Li-fan LIU Xiao-qing ZHANG Yao DENG Guo-hua Manish Pareek Ajit Lalvani | 2013 | Chinese Medical Journal2013，，11： | 10 |
| 2 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 3 | Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars显示文摘New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly.Mycobacteria have a unique cell wall.Deletion of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG.The nat gene and its associated gene cluster are almost identical in sequence in M.bovis BCG and M.tuberculosis.The gene cluster is essential for intracellular survival of mycobacteria.We have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT activity.Here,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both M.bovis BCG and M.tuberculosis.The most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular survival.We also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity relationships.We conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved. | Isaac M.Westwood Sanjib Bhakta Angela J.Russell Elizabeth Fullam Matthew C.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim | 2010 | Protein & Cell2010，1，1： | 3 |
| 4 | Cytotoxic T-lymphocyte epitopes for HLA-B53 and other HLA types in the malaria vaccine candidate liver-stage antigen 3 显示文摘 | Aidoo M Lalvani A Gilbert SC | 2000 | Infect Immun2000，68，1： | 1 |
| 5 | Diagnosing tuberculosis infection in the 21 st century: new tools to tackle an old enemy显示文摘 | Lalvani A | 2007 | Chest2007，131，6： | 1 |
| 6 | Arsenate remediation using nanosized modified zerovalent iron particles显示文摘 | Jegadeesan G Mondal K Lalvani S B | 2005 | Environ Prog2005，24，： | 1 |
| 7 | Spotting latent infection:the path tO better tuberculsis contr01显示文摘 | Lalvani A | | 0，，： | 1 |
| 8 | A 100 year update on diagnosis oftuberculosis infection显示文摘 | Lalvani A Pareek M | 2010 | Br Med Bull2010，93，： | 1 |
| 9 | Interferon gamma release assays;principles and practice显示文摘 | Lalvani A Pareek M | 2010 | Enferm Infecc Microbiol C1in2010，28，4： | 1 |
| 10 | Cytotoxic T- lymphocyte epitopes for IKA- B 53 and other IKA types in the malaria vaccine candidate liver- stage antigen 3显示文摘 | Aidoo M Lalvani A Gilbert SC | 2000 | Infect Immun2000，68，1： | 1 |
| 11 | Characterization ofsemiconducting properties of naturally occurring polycrystal-line FeS2(pyrite)显示文摘 | Lalvani S B Weston A Masden J T | 1990 | Journal of Materials Science1990，25，1： | 1 |
| 12 | A 100 year update on diagnosis of tuberculosis infection显示文摘 | Lalvani A Pareek M | 2010 | Br Med Bull2010，93，： | 1 |
| 13 | Interferon gamma release assays: principles and practice显示文摘 | Lalvani A Pareek M | 2010 | Enferm Infecc Microbiol Clin2010，28，4： | 1 |
| 14 | Low temperature soybean oil hydrogenation by an electrochemical process显示文摘 | Mondal K Lalvani S | 2008 | Journal of Food Engineering2008，84，4： | 1 |
| 15 | Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy显示文摘 | Lalvani A | 2007 | Chest2007，131，6： | 1 |
| 16 | Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cell显示文摘 | Lalvani A Pathan AA Mcshane H | 2001 | Am J Respir Crit Care Med2001，163，4： | 1 |
| 17 | Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells显示文摘 | Lalvani A Pathan AA Durkan H | 2001 | Lancet2001，357，9273： | 1 |
| 18 | Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells 显示文摘 | Lalvani A Pathan AA McShane H | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 19 | Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit caccine candidates by comparative genomics显示文摘 | PJ Cockle SV Gordon A Lalvani | | 0，，： | 1 |
| 20 | Prognostic value of a T-cell- based interferon-gamma biomarker in children with tuberculosis contact 显示文摘 | Bakir M Millington KA Soysal A Deeks JJ Efee S Asian Y Dosanjh DP Lalvani A | 2008 | Ann Intern Med2008，149，11： | 1 |
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