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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Monitoring microbial biomass and respiration in different soils from the Czech Republic:a summary of results显示文摘 | JAKUB H LADISLAV D JANA K | 2004 | Environment International2004，，30： | 1 |
| 3 | Can viable pollen carry Scots pine genes over long distances? 显示文摘 | Lindgren D Ladislav P Shen X H | 1995 | Grana1995，34，1： | 1 |
| 4 | Methods for isolation of Streptoverticillia from Soils显示文摘 | LADISLAV F H RONDA D S | 1988 | J Antibiot1988，41，4： | 1 |
| 5 | Hydrophilic polycarbonate chips for generation of oil-in-water(O/W) and water-in-oil-in-water (W/O/W) emulsions 显示文摘 | PAWEL J DOMINIKA O LADISLAV D | 2013 | Microfluid Nanofluid2013，14，1： | 1 |
| 6 | Structural characterization of photosystem 1] complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex 显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Bio- chemist2005，271，14： | 1 |
| 7 | Structural characterization of photosystem II complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Biochemist2005，271，： | 1 |
| 8 | Presymptomatic spondylotic cervical cord compression显示文摘 | Josef B Zdenek Ladislav D | | 0，，20： | 1 |
| 9 | Structural characterization of photosystem Ⅱ complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex Eur显示文摘 | Ladislav B Helena H D Michal H | 2005 | Biochemist2005，271，： | 1 |
| 10 | Suspended bridges subjected to moving loads and support motions due to earthquake显示文摘 | LADISLAV F B YAU J D | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 11 | Structure, zonation, and species diversityof the mayfly communities of the Belá River basin,Slovakia 显示文摘 | Pavel D Ladislav M S | 1986 | Hydrobiologia1986，135，： | 1 |
| 12 | Suspended bridges subjected to moving loads and support motions due to earthquake显示文摘 | LADISLAV F B YAU J D | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 13 | Monitoring microbial bio mass and respiration in differentsoils from the Czech Re- public: A summary of results显示文摘 | Jakub H Ladislav D Jana K | 2004 | Environment Interna- tional2004，30，1： | 1 |
| 14 | The relationship between the cervical and anal HPV infection in women with cervical intra- epithelial neoplasia显示文摘 | Borek S Ladislav D David C | 2014 | J Clin Virol2014，59，1： | 1 |
| 15 | Degradable magnesium-hydroxyapatite interpenetrating phase composites processed by current assisted metal infiltration in additive-manufactured porous preforms显示文摘This work explores ceramic additive manufacturing in combination with liquid metal infiltration for the production of degradable interpenetrating phase magnesium/hydroxyapatite(Mg/HA) composites. Material extrusion additive manufacturing was used to produce stoichiometric,and calcium deficient HA preforms with a well-controlled open pore network, allowing the customization of the topological relationship of the composite. Pure Mg and two different Mg alloys were used to infiltrate the preforms by means of an advanced liquid infiltration method inspired by spark plasma sintering, using a novel die design to avoid the structural collapse of the preform. Complete infiltration was achieved in 8 min, including the time for the Mg melting. The short processing time enabled to restrict the decomposition of HA due to the reducing capacity of liquid Mg. The pure Mg-base composites showed compressive yield strength above pure Mg in cast state. Mg alloy-based composites did not show higher strength than the bare alloys due to grain coarsening, but showed similar mechanical properties than other Mg/HA composites that have significantly higher fraction of metallic phase. The composites showed faster degradation rate under simulated body conditions than the bare metallic component due to the formation of galvanic pairs at microstructural level. Mg dissolved preferentially over HA leaving behind a scaffold after a prolonged degradation period. In turn, the fast production of soluble degradation products caused cell metabolic changes after 24 h of culture with not-diluted material extracts. The topological optimization and reduction of the degradation rate are the topics for future research. | Mariano Casas-Luna Edgar B.Montufar Norbert Hort Sebastian Díaz-de-la-Torre JoséClaudio Méndez-García Lucie Vištejnová Adam Brínek AlešDanhel Karel Dvorak Jozef Kaiser Ladislav Celko | 2022 | Journal of Magnesium and Alloys2022，10，12： | 0 |
| 16 | Long-term outcomes of the four-corner fusion of the wrist:A systematic review显示文摘BACKGROUND Four-corner fusion(4CF)is a motion sparing salvage procedure that is used to treat osteoarthritis secondary to advanced scapholunate collapse or longstanding scaphoid nonunion advanced collapse.Little is known about the long-term survivorship and outcomes of 4CF.AIM To report on clinical and functional long-term outcomes as well as conversion rates to total wrist fusion or arthroplasty.METHODS The systematic review protocol was registered in the international prospective register of systematic reviews(PROSPERO)and followed the PRISMA guidelines.Original articles were screened using four different databases.Studies with a minimum Level IV of evidence that reported on long-term outcome after 4CF with a minimum follow-up of 5 years were included.Quality assessment was performed using the Methodological Index for Non-Randomized Studies criteria.RESULTS A total of 11 studies including 436 wrists with a mean follow-up of 11±4 years(range:6-18 years)was included.Quality assessment according to Methodological Index for Non-Randomized Studies criteria tool averaged 69%±11%(range:50%-87%).Fusion rate could be extracted from 9/11 studies and averaged 91%.Patient-reported outcomes were extracted at last follow-up from 8 studies with an average visual analog scale of 1±1(range:0-2)and across 9 studies with an average Disabilities of the Arm,Shoulder and Hand score of 21±8(range:8-37).At last follow-up,the cumulative conversion rate to total wrist fusion averaged 6%.There were no conversions to total wrist arthroplasty.CONCLUSION The 4CF of the wrist is a reliable surgical technique,capable of achieving a good long-term patient satisfaction and survivorship with low rates of conversion to total wrist fusion. | Octavian Andronic Ladislav Nagy Marco D Burkhard Fabio A Casari Daniel Karczewski Philipp Kriechling Andreas Schweizer Lukas Jud | 2022 | World Journal of Orthopedics2022，13，1： | 0 |
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