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| 1 | Loop mediated isothermal amplification (LAMP): a new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases显示文摘 | ManmohanParida SanthoshSannarangaiah Paban KumarDash P. V. L.Rao KouichiMorita | 2008 | Rev Med Virol2008，，6： | 1 |
| 2 | Loop mediated isothermal amplification (LAMP): a new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases显示文摘 | ManmohanParida SanthoshSannarangaiah Paban KumarDash P. V. L.Rao KouichiMorita | 2008 | Rev. Med. Virol2008，，： | 1 |
| 3 | The impact of dysfunctional tear films and optical aberrations on chronic migraine显示文摘Background:Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms,including ocular manifestations.Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis.The current study investigates the association between a dysfunctional tear film and ocular aberrations with migraine.Methods:Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were studied.Dry eye evaluation included Schirmer’s test,tear film break-up time,corneal esthesiometry and lipid layer analysis using Lipiview^(®)interferometer.Wavefront aberrations were measured using Optical Path Difference before performing the dry eye evaluation.The intraocular light scatter was quantified using the objective scatter index(OSI)of the optical quality analysis system.Measured parameters were compared between the migraine and the control group using independent sample t-test.Statistical analysis was performed using commercial software.A p value of≤0.05 was considered statistically significant.Results:There were 19 females and 11 males in each group.Statistically significant difference was found between the two groups with respect to total aberrations(p=0.049),higher order aberrations(p=0.009),coma(p=0.03),spherical aberrations(p=0.018),Lipiview interferometric coloric units(p<0.001)and OSI(p<0.001).Trefoil(p=0.26)and TBUT(p=0.398)were not significantly different between both groups.Conclusions:Ocular aberrations are higher in patients with migraine as compared with controls.Tear film abnormalities add to the aberrations in otherwise asymptomatic patients and may also be associated with migraineous attacks.Treating the ocular surface to obtain a healthy tear film might introduce a potential modifiable factor in the prevention of migraneous attacks. | Rohit Shetty Kalyani Deshpande Chaitra Jayadev Kareeshma Wadia Pooja Mehta Rushad Shroff Harsha L.Rao | 2017 | Eye and Vision2017，4，1： | 0 |
| 4 | 重症监护病房上消化道出血患者病死率及需内镜干预的预测因素显示文摘背景:重症监护病房(ICU)患者因上消化道出血(UGIB)行食管胃十二指肠镜检查(EGD)的临床结局尚不甚明了。本研究旨在明确这些患者30天病死率及需内镜干预的预测因素,并评估目前已有的UGIB临床预测工具是否适用于ICU人群。方法:通过一种已被证实有效的机器学习计算程序,筛选出2008-2015年间接受EGD的ICU住院病例。采用逻辑回归分析明确其30天病死率和内镜干预的影响因素。采用受试者操作特征曲线下面积(AUROC)分析来评估已有的UGIB评分系统对这些ICU患者病死率和内镜干预的预测价值。结果:共计606例患者入住ICU后因UGIB接受EGD检查,中位年龄62岁,55.9%为男性。多因素分析显示,30天病死率的独立预测因素包括ASA分级(OR 4.1,95%CI:2.2-7.9)、Charlson评分(OR 1.2,95%CI:1.0-1.3)和入院至EGD检查的间隔时间(OR 1.04,95%CI:1.01-1.07)。Rockall、Glasgow-Blatchford和AIMS65三种评分系统对内镜干预(AUROC分别为0.521、0.514和0.540)和病死率(AUROC分别为0.510、0.568和0.506)的预测效果均较差。结论:ASA评分、Charlson评分和入院至EGD检查的间隔时间可有效预测ICU中UIGB患者的病死率。目前已有的UIGB预测工具对ICU患者的预测价值极为有限,因此,需要建立一个更加准确的ICU患者风险分层工具来预测内镜干预是否有益。 | Vijaya L.Rao Nina Gupta Eric Swei Thomas Wagner Andrew Aronsohn KGautham Reddy Neil Sengupta | 2020 | Gastroenterology Report2020，8，4： | 0 |
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