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| 1 | Invasive mechanism and management strategy of Bemisia tabaci(Gennadius) biotype B:Progress report of 973 Program on invasive alien species in China显示文摘Bemisia tabaci(Gennadius) biotype B,called a 'superbug',is one of the most harmful biotypes of this species complex worldwide.In this report,the invasive mechanism and management of B.tabaci biotype B,based on our 5-year studies,are presented.Six B.tabaci biotypes,B,Q,ZHJ1,ZHJ2,ZHJ3 and FJ1,have been identified in China.Biotype B dominates the other biotypes in many regions of the country.Genetic diversity in biotype B might be induced by host plant,geographical conditions,and/or insecticidal application.The activities of CarE(carboxylesterase) and GSTs(glutathione-S-transferase) in biotype B reared on cucumber and squash were greater than on other host plants,which might have increased its resistance to insecticides.The higher activities of detoxification enzymes in biotype B might be induced by the secondary metabolites in host plants.Higher adaptive ability of biotype B adults to adverse conditions might be linked to the expression of heat shock protein genes.The indigenous B.tabaci biotypes were displaced by the biotype B within 225 d.The asymmetric mating interactions and mutualism between biotype B and begomoviruses via its host plants speed up widespread invasion and displacement of other biotypes.B.tabaci biotype B displaced Trialeurodes vaporariorum(Westwood) after 4-7 generations under glasshouse conditions.Greater adaptive ability of the biotype B to adverse conditions and its rapid population increase might be the reasons of its successful displacement of T.vaporariorum.Greater ability of the biotype B to switch to different host plants may enrich its host plants,which might enable it to better compete with T.vaporariorum.Native predatory natural enemies possess greater ability to suppress B.tabaci under field conditions.The kairomones in the 3rd and 4th instars of biotype B may provide an important stimulus in host searching and location by its parasitoids.The present results provide useful information in explaining the mechanisms of genetic diversity,evolution and molecular eco-adaptation of biotype B.Furthermore,it provides a base for sustainable management of B.tabaci using biological and ecological measures. | WAN FangHao1,ZHANG GuiFen1,LIU ShuSheng2,LUO Chen3,CHU Dong4,ZHANG YouJun4,ZANG LianSheng2,JIU Min2,Lü ZhiChuang1,CUI XuHong1,ZHANG LiPing4,ZHANG Fan3,ZHANG QingWen5,LIU WanXue1,LIANG Pei5,LEI ZhongRen1 & ZHANG YongJun1 1 State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Acadeny of Agriculture Sciences,Beijing 100094,China 2 Institute of Applied Entomology,Zhejiang University,Hangzhou 310029,China 3 Institute of Plant and Environment Protection,Beijing Academy of Agricultural and Forestry Sciences,Beijing 100089,China 4 Institute of Vegetables and Flowers,Chinese Acadeny of Agricullare Sciences,Beijing 100081,China 5 Department of Entomology,China Agriculture University,Beijing 100094,China | 2009 | Science China(Life Sciences)2009，52，1： | 30 |
| 2 | 外显子测序识别脑干胶质瘤体细胞获得性功能PPM1D基因突变显示文摘发生于脑干和丘脑的胶质瘤是一类毁灭性肿瘤,难以通过手术切除。为确定这些肿瘤的遗传和表观遗传学背景,作者对14例脑干胶质瘤( BSGs)和12例丘脑胶质瘤病例进行外显子组测序。同时该团队通过针对性突变分析对另外24例该类肿瘤及45例脑胶质瘤进行全基因组甲基化谱进行分析。这项研究发现肿瘤特异性突变PPM1D,该突变编码野生型p53蛋白诱导的蛋白磷酸酶1D(WIP1),其在37.5%的脑干胶质瘤中存在标志性的H3F3A基因突变导致编码第27号染色体使赖氨酸转换为甲硫氨酸。脑干胶质瘤中PPM1D基因突变和TP53基因突变互斥抑制并且在体外实验中可以衰减p53蛋白活化。 PPM1D基因突变能够缩短外显子6来增强PPM1D抑制DNA损伤反应的检验CHK2蛋白激活的能力。这些研究结果表明PPM1D可以作为体细胞突变常用的靶点以及脑干胶质瘤治疗中的潜在靶点。 | Zhang L Chen L H Wan H 王晶晶 许春伟 张博 | 2014 | 临床与实验病理学杂志2014，30，12： | 15 |
| 3 | Tectonic Evolution of the Middle Frontal Area of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘由分析平衡的生气的节和 Longmen 山戳带的沉淀历史,中国,我们断定它经历了五个构造阶段:(1 ) 形成阶段(T 3 x ) Longmen 的缩影,山,早 Indosinian 运动,和 Anxian 构造运动创造了 Longmen 山;(2 ) 稳定的构造阶段(更弱的构造运动导致了 Longmen 山戳带的 J 1) 稍微正在被高举并且稍微减退低岬盆;(3 ) 强烈构造阶段(J2.3 ) ,也就是早 Yanshan 运动;(4 ) 连续构造运动(K-E ) ,也就是迟了的 Yanshan 运动和早喜玛拉雅的运动;并且(5 ) Longmen 山(N-Q ) 的形成,也就是晚喜玛拉雅的运动。在那些构造变丑阶段期间, Anxian 运动和喜玛拉雅的运动在 Longmen 山的形成起了重要作用。喜玛拉雅的运动影响了 Longmen 山大多数;阶层强烈地推进了并且严重地被侵蚀。因为一些越过水坝落下的水被推,在 Longmen 山戳带的中间的部分有某 klippes 在以后向东南构造变丑。 | JIN Wenzheng TANG Liangjie YANG Keming WAN Guimei Lü Zhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 4 | Open globe injury in Hospital Universiti Sains Malaysia- a 10-year review显示文摘AIM:To identify the aetiology of open globe injuries at Hospital Universiti Sains Malaysia over a period of 10y and the prognostic factors for visual outcome.METHODS:Retrospective review of medical records of open globe injury cases that presented from January2000 to December 2009.Classification of open globe injury was based on the Birmingham Eye Trauma Terminology(BETT).Records were obtained with hospital permission via the in-house electronic patient management system,and the case notes of all patients with a diagnosis of open globe injury were scrutinised.Patients with prior ocular trauma,pre-existing ocular conditions affecting the visual acuity,contrast sensitivity,central vision or corneal thickness,as well as those with a history of previous intraocular or refractive surgery were excluded.Analysis of data was with SPSS version20.0.Ordinal logistic regression analysis was used to examine the association between prognostic factors and visual outcome.RESULTS:This study involved 220 patients(n=222eyes).The most common place of injury was the home(51.8%),followed by the workplace(23.4%).Among children aged less than 16y of age,domestic-related injury was the predominant cause(54.6%),while in those aged 16y and above,occupational injuries were the most common cause(40.0%).Most eyes(76.5%)had an initial visual acuity worse than 3/60,and in half of these,the visual acuity improved.The visual outcome was found to be significantly associated with the initial visual acuity(P<0.005),posterior extent of wound(P<0.001),length of wound(P<0.001),presence of hyphaema(P<0.001)and presence of vitreous prolapse(P<0.005).CONCLUSION:The most common causes of open globe injury are domestic accidents and occupational injuries.Significant prognostic factors for final visual outcome in patients with open globe injury are initial visual acuity,posterior extent and length of wound,presence of hyphaema and presence of vitreous prolapse.Awareness of the factors predicting a poor visual outcome may be helpful during counselling of patients with open globe injuries. | Madhusudhan A/L Paramananda Evelyn-Tai Li Min Zamri Noordin Adil Hussein Wan-Hazabbah Wan Hitam | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 9 |
| 5 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 6 | Density and Seasonal Dynamics of Bemisia tabaci(Gennadius) Mediterranean on Common Crops and Weeds Around Cotton Fields in Northern China显示文摘The density seasonal dynamics of Bemisia tabaci MED were evaluated over two years in a cotton-growing area in Langfang, Hebei Province, northern China on cotton(Gossypium hirsutum L.) and six other co-occurring common plants, common ragweed(Ambrosia artemisiifolia L.), piemarker(Abutilon theophrasti Medicus), sunflower(Helianthus annuus L.), sweet potato(Ipomoea batatas L.), soybean(Glycine max L.), and maize(Zea mays L.). The whitefly species identity was repeatedly tested and confirmed; seasonal dynamics on the various host plants were standardized by the quartile method. B. tabaci MED appeared on weeds(the common ragweed and piemarker) about 10 days earlier than on cotton, or the other cultivated plants. The peak population densities were observed over a span of 2 to 3 weeks on cotton, starting in early(2010) or mid-August(2011). The common ragweed growing adjacent to cotton supported the highest B. tabaci d ensities(no. on 100 cm2 leaf surface), 1 2-22 fold higher than on cotton itself. Sunflower supported more B. tabaci than the other plants, and about 1.5-2 fold higher than cotton did. Our results indicate that weeds(esp. the common ragweed) around cotton fields could increase the population density of B. tabaci MED on cotton, while sunflower could act as a trap crop for decreasing pest pressure on cotton. | ZHANG Xiao-ming YANG Nian-wan WAN Fang-hao Gabor L Lvei | 2014 | Journal of Integrative Agriculture2014，13，10： | 8 |
| 7 | Differential Tectonic Deformation of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘地调查和地震的节解释证明 Longmen 山戳带有明显的微分变丑:带状配列,分割和层化。带状配列意味着那,从 NW 到 NE, Longmen 山戳带能被划分成 Songpan-Garz ê构造的带,可锻的变丑带,基础深奥的戳带,正面的褶层戳带,和低岬消沉。它能向南向北被划分成五个片断从到的分割工具:北片断, Anxian 转移地区,中心片断, Guanxian 转移地区和南部的片断。层化意味着分开层在侧面划分结构的式样。在 Longmen 山戳带的分开层能被分类进三个范畴:深水平的分开层包括外壳披风系统分开层, intracrustal 分开层,和 Presinian 系统基础分开层;中间级的分开层包括寒武纪奥陶纪的分开层,志留纪分开层,等等;并且浅水平的分开层,包括的上面的三叠纪的 Xujiahe 形成分开层和侏罗记分开层。多水平分开层在塑造和 Longmen 山戳带的进化上有很重要的效果。 | TANG Liangjie YANG Keming JIN Wenzheng WAN Guimei LüZhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 6 |
| 8 | Osteopontin gene polymorphism in association with systemic lupus erythematosus in Chinese patients显示文摘背景 Osteopontin ( OPN )是能在支持 T 淋巴细胞的激活起很多个作用的一个种 cytokine ,调整在 Th1 和 Th2 之间的平衡,参予导致房间的 immunologic 反应并且刺激 B 淋巴细胞表示多克隆 antibodies.Some 研究证明了 OPN 可以涉及这研究的 .The 目的是在位置 9250 点调查单个核苷酸多型性( SNP )的可能的协会在里面的全身的豺狼座 erythematosus ( SLE ) | XU An-ping BAI Jie Lü Jun LIANG Yan-yi LI Jin-gao LAI De-yuan WAN Xia HUANG Hu-hui | 2007 | Chinese Medical Journal2007，，23： | 6 |
| 9 | Establishment and validation of a model for brain injury state evaluation and prognosis prediction显示文摘Purpose:Traumatic brain injury(TBI)is one of the leading causes of disability and death in modern times,whose evaluation and prognosis prediction have been one of the most critical issues in TBI management.However,the existed models for the abovementioned purposes were defective to varying degrees.This study aims to establish an ideal brain injury state clinical prediction model(BISCPM).Methods:This study was a retrospective design.The six-month outcomes of patients were selected as the end point event.BISCPM was established by using the split-sample technology,and externally validated via different tests of comparison between the observed and predicted six-month mortality in validating group.TBI patients admitted from July 2006 to June 2012 were recruited and randomly divided into establishing model group and validating model group.Twenty-one scoring indicators were included in BISCPM and divided into three parts,A,B,and C.Part A included movement,pupillary reflex and diameter,CT parameters,and secondary brain insult factors,etc.Part B was age and part C was medical history of the patients.The total score of part A,B and C was final score of BISCPM.Results:Altogether 1156 TBI patients were included with 578 cases in each group.The score of BISCPM from validating group ranged from 2.75 to 31.94,averaging 13.64±5.59.There was not statistical difference between observed and predicted mortality for validating group.The discrimination validation showed that the BISCPM is superior to international mission for prognosis and analysis of clinical trials(IMPACT)lab model.Conclusion:BISCPM is an effective model for state evaluation and prognosis prediction of TBI patients.The use of BISCPM could be of great significance for decision-making in management of TBI. | Xia Li Chao Lü Jun Wang Yi Wan Shu-Hui Dai Lei Zhang Xue-An Hu Xiao-Fan Jiang Zhou Fei | 2020 | Chinese Journal of Traumatology2020，23，5： | 3 |
| 10 | Microstructure and properties of pure iron/copper composite cladding layers on carbon steel显示文摘In the present study, pure iron/copper composite metal cladding was deposited onto carbon steel by tungsten inert gas welding. The study focused on interfacial morphological, microstructural, and mechanical analyses of the composite cladding layers. Iron liquid–solid-phase zones were formed at copper/steel and iron interfaces because of the melting of the steel substrate and iron. Iron concentrated in the copper cladding layer was observed to exhibit belt, globule, and dendrite morphologies. The appearance of iron-rich globules indicated the occurrence of liquid phase separation(LPS) prior to solidification, and iron-rich dendrites crystallized without the occurrence of LPS. The maximum microhardness of the iron/steel interface was lower than that of the copper/steel interface because of the diffusion of elemental carbon. All samples fractured in the cladding layers. Because of a relatively lower strength of the copper layer, a short plateau region appeared when shear movement was from copper to iron. | Long Wan Yong-xian Huang Shi-xiong Lü Ti-fang Huang Zong-liang Lü | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，8： | 3 |
| 11 | Homogenization and Trend Analysis of Canadian Near-Surface Wind Speeds显示文摘 | Wan Hui Wang Xiaolan L Swail Val R | 2010 | Journal of Climate2010，，5： | 3 |
| 12 | Dielectric Properties of Polytetrafluoroethylene/CaCu_3Ti_4O_(12) Composites显示文摘Polymer-based composite was investigated by embedding calcium copper titanate(CaCu_3Ti_4O_(12); CCTO) fillers into polytetrafluoroethylene(PTFE) matrix. The dielectric performances of the composite were investigated within the frequency range from 100 Hz to 1 MHz. It is indicated that dielectric permittivity(ε) and dielectric loss(tanδ) increase gradually as the filler content increases. Dielectric permittivity for the composite with 50 vol% CCTO filler loading is 33.5, approximately 16 times higher than that of pure PTFE(ε = 2.1) at 100 Hz. As the frequency increases, the dielectric loss decreases rapidly and reaches stability, and then remains low when the frequency rises to 1 MHz. The values for dielectric permittivity and dielectric loss in the microwave frequency(8-13 GHz) are lower than that in low frequency of 10 kHz for the composites because of different polarization modes. Several theoretical models were implemented to compare the experimental results with the theoretical calculations and the modified Lichtenecker equation was found to fit the best. | 梁飞 ZHAO Yifei CHEN Xizi WAN Qianxing Lü Wenzhong | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 3 |
| 13 | Computational Insights into Interactions between Ca Species and α-Fe_2O_3(001)显示文摘CaCl2 can be sprayed onto sinter surface,which can improve the low temperature reduction degradation index(RDI+3.15)of sinter.This has been recognized;however,there are various opinions on the inhibition mechanism of it.At the same time,the corrosion of Cl element on equipment is very serious.First-principle calculations based on density functional theory were performed to investigate the binding mechanisms of calcium species on a α-Fe2O3(0 0 1) surface.This is crucial in demonstrating the role of the CaCl2 on improving the low temperature reduction degradation index.It has been determined that Cl could greatly increase the adsorption of the vacuum layer for the Ca/Fe2O3 system and the relaxation produced by adsorption made bond length decrease,bond energies increase and structure compact.Those are the main reasons that inhibiting the reduction disintegration of sinter. | Yan-qin SUN Qing L Xin-yu WAN Shu-hui ZHANG Jiong-ming ZHANG | 2014 | Journal of Iron and Steel Research(International)2014，21，4： | 3 |
| 14 | Preparation and development of equine hyperimmune globulin F(ab')_2 against severe acute respiratory syndrome coronavirus显示文摘Aim:The resurgence of severe acute respiratory syndrome(SARS)is still a threatbecause the causative agent remaining in animal reservoirs is not fully understood,and sporadic cases continue to be reported.Developing high titers of anti-SARShyperimmune globulin to provide an alternative pathway for emergent future pre-vention and treatment of SARS.Methods:SARS coronavims(CoV)F69(AY313906)and Z2-Y3(AY394989)were isolated and identified from 2 different Cantoneseonset SARS patients.Immunogen was prepared from SARS-CoV F69 strain.Sixhealth horses were immunized 4 times and serum was collected periodically tomeasure the profile of specific IgG and neutralizing antibodies using indirect en-zyme-linked immunosorbent assay and a microneutralization test.Sera were col-lected in large amounts at the peak,where IgG was precipitated using ammoniumsulphate and subsequently digested with pepsin.The product was then purifiedusing anion-exchange chromatography to obtain F(ab′)2 fragments,Results:Thespecific IgG and neutralizing antibody titers peaked at approximately week 7 afterthe first immunization,with a maximum value of 1:14210.The sera collected at thepeak were then purified.Fragment of approximately 15 g F(ab′)2 was obtained from1 litre antiserum and the purity was above 90% with the titer of 1:5120,which couldneutralize the other strain(SARS-CoV Z2-Y3)as well.Conclusion:This researchprovides a viable strategy for the prevention and treatment of SARS coronavirusinfection with equine hyperimmune globulin,with the purpose of combating anyresurgence of SARS. | Jia-hai LU Zhong-min GUO Wen-yu HAS Guo-ling WAN Ding-mei ZHANG Yi- fei WANG Sheng-yun SUN Qin-he YANG Huan-ying ZHENG Bing L WONG Nan-shan ZHONG | 2005 | Acta Pharmacologica Sinica2005，26，12： | 2 |
| 15 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 16 | Identification and estimation of the biomass burning contribution to Beijing aerosol using levoglucosan as a molecular marker显示文摘 | Ting Zhang Magda Claeys Hélène Cachier Shuping Dong Wan Wang Willy Maenhaut Xiande Liu | 2008 | Atmospheric Environment2008，，29： | 2 |
| 17 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 18 | Synthesis and characterization of hydroxyapatite-bacterial cellulose nanocomposites显示文摘 | Wan Y Z Hong L | 2005 | Composites Science and Technology2005，66，1112： | 1 |
| 19 | Preparation and characterization of gelatin gel with a gradient structure 显示文摘 | Wang Y L Cheng G X Yao K D | 2000 | Polymer Int2000，49，12： | 1 |
| 20 | Interface Preserving Coarsening Multigrid for Elliptic Problems with Highly Discontinuous Coefficients显示文摘 | | 2000 | Numerical Linear Algebra with Application2000，7，78： | 1 |
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