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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | Improved cryopreservation of human embryonic stem cells with trehalose显示文摘 | Wu CF Tsung HC Zhang W J Wang Y Lu JH Tang ZY Kuang YP Jin W Cui L Liu W Cao YL | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 4 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 5 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 6 | Application of support vector machines in financial time series forecasting 显示文摘 | TAY F E H CAO L J | 2001 | Omega2001，29，4： | 1 |
| 7 | Mural granulosa cellgene expression associated with oocye developmental compe-tence显示文摘 | Jiang J Y Xiong H L Cao M J | 2010 | Ovarian Res2010，3，1： | 1 |
| 8 | Detection of yellow head virus and Chinese baculovirus in penaeid shrimp by the western blot technique显示文摘 | Nadala E J Tapay L M Cao S | 1997 | J Virol Methods1997，69，： | 1 |
| 9 | Modified support vector machines in financial time series forecasting显示文摘 | TAY F E H CAO L J | 2002 | Neurocomputing2002，48，： | 1 |
| 10 | A highly soluble dimethoxybenzene derivative as a redox shuttle for overcharge protection of secondary lithium batteries显示文摘 | Feng J K Ai X P Cao L | 2006 | Electrochem Commun2006，9，： | 1 |
| 11 | A comparision of PCA, KPCA and ICA for dimensionality reduction in support vector machine显示文摘 | Cao L J Chua K S Chong W K | 2003 | Neurocomputing2003，55，2： | 1 |
| 12 | Support vector machine with adaptive parameters in financial time series forecasting显示文摘 | Cao L J Tay Francis E H | 2003 | IEEE Trans- actions on Neural Networks2003，6，14： | 1 |
| 13 | The effect of exercise training on the metabolic interaction between digestion and locomotion in juvenile darkbarbel catfish (Peltebagrus vachelli) 显示文摘 | Li X M Cao Z D Peng J L | 2010 | Comparative Biochemistry and Physiology Part A2010，156，1： | 1 |
| 14 | CCCH-type zinc finger fam- ily in maize:genome-wide identi{ication, classification and ex- pression profiling under abscisic acid and drought treatments 显示文摘 | Peng X J Zhao Y Cao J G et a l | 2012 | PLoS One2012，7，40： | 1 |
| 15 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 16 | FNS therapy for the functional restoration of the paralysed eyelid显示文摘 | Cao J Li L Tong K | 2009 | J Plast Reconstr Aesthet Surg2009，62，12： | 1 |
| 17 | 查看详情显示文摘 | Wu D J Cao L Ke S Z | | 0，，： | 1 |
| 18 | 查看详情显示文摘 | Wang G E Qin W P Zhang J S Zhang J S Wang Y Cao C Y Wang L L Wei G D Zhu P E Wu C E Kim Ryongjin | | 0，，： | 1 |
| 19 | Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages显示文摘 | Cao J Han Z Tian L | 2014 | J Transl Mcd2014，12，1： | 1 |
| 20 | Hydrothermal synthesis of Zn-doped Li4TisOlz with improved high rate properties for lithium ion batteries显示文摘 | ZHANG Z CAO L HUANG J | 2013 | Ceramics International2013，39，： | 1 |
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