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| 1 | 子宫内膜异位症妇女月经期腹膜及子宫内膜生物学相关细胞因子和生长因子的基因表达增加显示文摘Objective: To examine differential messenger RNA(mRNA)-expression of relevant cytokines, metalloproteases, growth and adhesion factors in endometrium and peritoneum from women with endometriosis when compared with women without the disease duringmenstrual and luteal phases of the cycle. Design: Patients with endometriosis were compared with control patients. Setting: University hospital. Patient(s): A total of 35 patients(20 patients during the luteal phase and 15 patients during the menstrual phase)were selected for this study on the basis of cycle phase and presence or absence of endometriosis. Intervention( s): In this study, endometriosis was laparoscopically and histologically confirmed in 24 women with endometriosis of revised American Society for Reproductive Medicine(ASRM) stage I-II(n=12) and revised ASRM stage III-IV(n=12), and the presence of a normal pelvis was documented by laparoscopy in 11 control patients. The macroscopically normal peritoneum tissues were collected from lateral wall left or right, near the colon ascendens or descendens. Main Outcome Measure(s): The expression levels were determined as ratios between the target molecules and β-actin as housekeeping gene. Result(s): In women with endometriosis, peritoneal mRNA levels of matrix metalloproteinase(MMP)-3, transforming growth factor-β, interleukin(IL)-6, and intercellular adhesion molecule-1 and endometrial mRNA levels of MMP-3, tumor necrosis factor(TNF)-α, and IL-8 were significantly higher during the menstrual phase when compared with luteal phase. During the menstrual phase of the cycle, both endometrial expression of TNF-α, IL-8, and MMP-3 mRNA levels and peritoneal expression of transforming growth factor-β, IL-6, and intercellular adhesion molecule-1 mRNA levels were significantly higher in women with endometriosis when compared with controls. Immunohistochemical staining confirmed the presence of TNF-αin peritoneum and endometrium in both women with endometriosis and controls. Conclusion(s): Increased endometrial and peritoneal cytokine mRNA expression during menstruation may contribute to a pelvic inflammatory microenvironment favoring the development of endometriosis. | Kyama C.M. Overbergh L. Debrock S. T.M. D'Hghe 党慧敏 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 2 | Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers 显示文摘 | Mihalyi A Gevaert C Kyama M | 2010 | Human Reproduction2010，3，25： | 1 |
| 3 | Endometrial and peritoneal expression of aromatase,cytokines,and adhesion factors in women with endometriosis显示文摘 | Kyama CM Overbergh L Mihalyi A | 2008 | Fertil Steril2008，89，2： | 1 |
| 4 | Potential involvement of the immune system in the development of endometriosis 显示文摘 | Cleophas M Kyama Sophie Debrock Jason M Mwenda | 2003 | Reprod Biol Endocrin2003，1，： | 1 |
| 5 | Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers 显示文摘 | Mihalyi A Gevaert O Kyama CM | 2010 | Hum Reprod2010，25，： | 1 |
| 6 | Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | KYAMA C M OVERBERGH L DEBROCK S | 2006 | Fertil Steril2006，85，6： | 1 |
| 7 | Endometrial and peritoneal expression of aromatase, cytokines and adhesion factors in women with endometriosis 显示文摘 | Kyama CM Overbergh L Mihalyi A | 2008 | Fertil Steri12008，89，3： | 1 |
| 8 | Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | Kyama CM Overbergh L Debrock S | 2006 | Fertil Steril2006，85，6： | 1 |
| 9 | Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis显示文摘 | Kyama CM Overbergh L Mihalyi A | 2008 | Fertil Steril2008，89，2： | 1 |
| 10 | End0metrial and peritoneal expression of aromatase, eytokines, and adhesion fac- tors in women with endometriosis 显示文摘 | Kyama CM Overbergh L Mihalyi A | 2008 | Fertil Steril2008，89，2： | 1 |
| 11 | Inereased peritoneal and endo-metrial gene expression of biologieally relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | Kyama CM Ovethergh L Debroek S | | 0，，06： | 1 |
| 12 | Role of immunologic and inflammatory factors in the development of endometriosis:indications for treatment strategies显示文摘 | Mihalyi A Kyama CM Simsa P | 2005 | Therapy2005，2，4： | 1 |
| 13 | Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis显示文摘 | Kyama CM Mihalyi A Gevaert O | 2011 | Fertil Steri12011，95，： | 1 |
| 14 | Future directions inendometriosis research显示文摘 | Df Hooghe TM Kyama C Debrock S | 2004 | Ann N Y Acad Sci2004，1034，： | 1 |
| 15 | Non-steroidahargets in the diagnosis and treatment of endometriosis显示文摘 | Kyama CM Mihalyi A Simsa P | 2008 | Curr Med Chem2008，15，10： | 1 |
| 16 | Endometrialand peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis 显示文摘 | Kyama C M Overbergh L Mihalyi A | 2008 | Fertil Steril2008，89，2： | 1 |
| 17 | Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers显示文摘 | Mihalyi A Gevaert O Kyama CM | 2010 | Hum Reprod2010，25，： | 1 |
| 18 | Potential involvement of the immune system in the development of endometriosis显示文摘 | Kyama CM Debrock S Mwenda JM | 2003 | Reprod Biol Endocrinol2003，2，1： | 1 |
| 19 | Future of en- dometriosis research显示文摘 | Peter Simsa Attila Mihalyi Cleophas M Kyama | 2007 | Future Med2007，3，： | 1 |
| 20 | Circumferential Strain Behavior During Creep Tests of Brittle Rocks显示文摘 | Fujll Y Kyama T Ishijima Y | 1999 | International Journal of Rock Mechanics and Mining Sciences1999，36，3： | 1 |
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