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| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | Antibiotic prophylaxis in elective thoracic surgery: cefuroxime versus ce fepime 显示文摘 | Turna A Kutlu C A Ozalp T | 2003 | Thorac Cardiovasc Surg2003，51，2： | 2 |
| 3 | Peripheral neuropa- thy and visual evoked potential changes in workers exposed to n-hexane显示文摘 | KUTLU G GOMCELI Y B SONMEZ T | 2009 | J Clin Neurosei2009，16，10： | 1 |
| 4 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Ficicioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 5 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Figicioglu C Kutlu T Demirbasoqlu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 6 | Estimating specificsurface area and cation exchange capacity in soils using fractaldimension of particle - size distribution 显示文摘 | ERSAHINS’GUNAL H KUTLU T | 2006 | Geoderma2006，136，34： | 1 |
| 7 | Early follicular anti-Mullerian hormone as an indicator of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Baglam E | 2006 | Fertil Steril2006，85，3： | 1 |
| 8 | Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane显示文摘 | Kutlu G Gomceli Y B Sonmez T | 2009 | J Clin Neurosci2009，16，10： | 1 |
| 9 | The role of inhibin B as a basal determinant of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 10 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Ficieioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endecrinol2003，17，4： | 1 |
| 11 | Associated brain anomalies and clinical findings in corpus caUosum dysgenesis显示文摘 | Alkan A Kutlu R Baysal T | 2003 | Tani Girisim Radyol2003，9，4： | 1 |
| 12 | Impact of clopidogrel on postoperative blood loss after non-elective coronary bypass surgery显示文摘 | Nurozler F Kutlu T Kucuk G | 2005 | Interact Cardiovasc Thorac Surg2005，4，6： | 1 |
| 13 | Early follicular antiMullerian hormone as an indicator of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Baglam E | 2006 | Fertil Steril2006，85，3： | 1 |
| 14 | Estimating specific surface area and cation exchange capacity in soils using fractal dimension of particle - size distribution显示文摘 | Ersahin S Gunal H Kutlu T | 2006 | Geoderma2006，136，34： | 1 |
| 15 | The firet identified hepatitisB vims vaccine escape mutation in Turkey 显示文摘 | Kutlu T Soy can LY t Kamtayl E | 2006 | Journal of clinicalvirology : the official publication of the Pan American Society forClinical Virology2006，35，2： | 1 |
| 16 | The role of inhibin B as a basal determinant of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 17 | Doppler Sonngraphy of the inferior and superior mesenteric arteries in ulceratire colitis显示文摘 | Sigirci A Baysal T kutlu R | 2001 | J clin ultrasound2001，29，3： | 1 |
| 18 | Early follicular anti-Mullerian hormone as an indicator of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Baqlam E | 2006 | Fertil Steril2006，85，3： | 1 |
| 19 | Antibiotic prophylaxis in elective thoracic surgery cefuroxime versus cefepime 显示文摘 | Turna A Kutlu CA Ozalp T | 2003 | Thorac Cardiovasc Surg2003，51，2： | 1 |
| 20 | Early follicular antiMullerian hormone as an indicator of ovarian reserve 显示文摘 | Ficicioglu C Kutlu T Baglam E | 2006 | Fertil Steril2006，85，3： | 1 |
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