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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | The Time Dimension and Lithium Resource Constraints for Electric Vehicles 显示文摘 | Kushnir D Sand~n B A | 2012 | Resources Policy2012，37，1： | 1 |
| 3 | Antidotal therapy of severe achte organophosphate poisoning: amultihospital study显示文摘 | Finkelsteein Y Kushnir A Raikhlirreisenkraft B | 1989 | Neurotoxicol Teratol1989，11，： | 1 |
| 4 | Quaternary ammonium compounds based on resin acids and rosin and their colloidal- chemical and bioeidal properties 显示文摘 | RADBIL B A KUSHNIR S R RADBIL' A B | 2008 | Russian Journal of Applied Chemistry2008，81，5： | 1 |
| 5 | The Time Dimension and Lithium Resource Constraints for Electric Vehicles显示文摘 | Kushnir D Sanden B A | 2012 | Resour Policy2012，37，： | 1 |
| 6 | Isotope composition of air moisture over the Mediterranean Sea:An index of the air-sea interaction pattern显示文摘 | Gat J R Klein B Kushnir Y | | 0，，： | 1 |
| 7 | Serum levels of mieroRNAs in patients with heart failure显示文摘 | Goren Y Kushnir M Zaffir B | 2012 | Eur J Heart Fail2012，14，2： | 1 |
| 8 | Synthesis of dehydroabietic chloride显示文摘 | Kushnir S R Borisova N V Radbil A B | 2003 | Russian Journal of Applied Chemistry2003，76，11： | 1 |
| 9 | Serum levels of microRNAs in patients with heart failure显示文摘 | GOREN Y KUSHNIR M ZAFRIR B | 2012 | Eur Heart Fail2012，14，： | 1 |
| 10 | Quantitation of nicotine, its metabolites, and other related alkaloids in urine, serum, and plasma using LC-MS-MS 显示文摘 | Yue B Kushnir MM Urry FM | 2010 | Methods Mol Biol2010，603，38： | 1 |
| 11 | Isotope composition of air moisture over the Mediterranean Sea: an index of the air-sea interaction pattern显示文摘 | Gat J R Klein B Kushnir Y | 2003 | Tellus B2003，55，5： | 1 |
| 12 | Sleep and sleepiness in children with nocturnal enuresis显示文摘 | Cohen-Zrubavel V Kushnir B Kushnir J | 2010 | SLEEP2010，34，2： | 1 |
| 13 | Sleep and sleepiness in children with nocturnal enuresis 显示文摘 | Cohen -Zrubavel V Kushnir B Kushnir J | 2011 | Sleep2011，34，2： | 1 |
| 14 | Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life 显示文摘 | Kushnir V M Cassell B Gyawali C P | 2013 | Aliment Pharmacol Ther2013，38，3： | 1 |
| 15 | Antidotal therapy of severe acute organophosphate poisoning:a multihospital study显示文摘 | Finkelsteein Y Kushnir A Raikhlin-eisenkraft B et a1 | 1989 | Neurotoxicol Teratol1989，11，： | 1 |
| 16 | Synthesis of dehydroabietic chloride显示文摘 | Kushnir S R Borisova N V Radbil A B | 2003 | Russian Journal of Applied Chemistry2003，76，11： | 1 |
| 17 | Serum levels of microRNAs in patients with heart failure显示文摘 | Goren Y Kushnir M Zafrir B | | 0，，02： | 1 |
| 18 | 显示文摘 | Marrack p Blackman M kushnir E The toxicity of Staphylococcal aureus enterotoxin B in mice is mediated by T cell | 1990 | Exp Med1990，171，： | 1 |
| 19 | Improvement of the hydrogenation technology of colophony 显示文摘 | SAVINYKH V I KUSHNIR S R RADBIL B A | 1992 | Gidroliz Lesokhim Promst1992，，3： | 1 |
| 20 | Serum levels of microRNAs in patients with heart failure显示文摘 | Goren Y Kushnir M Zaftir B | 2012 | Ear J Heart Fail2012，14，2： | 1 |
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