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| 1 | Current debate in the oncologic management of rectal cancer显示文摘Despite the considerable amount of research in the field,the management of locally advanced rectal cancer remains a subject to debate.To date,effective treatment centers on surgical resection with the standard approach of total mesorectal resection.Radiation therapy and chemotherapy have been incorporated in order to decrease local and systemic recurrence.While it is accepted that a multimodality treatment regimen is indicated,there remains significant debate for how best to accomplish this in regards to order,dosing,and choice of agents.Preoperative radiation is the standard of care,yet remains debated with the option for chemoradiation,short course radiation,and even ongoing studies looking at the possibility of leaving radiation out altogether.Chemotherapy was traditionally incorporated in the adjuvant setting,but recent reports suggest the possibility of improved efficacy and tolerance when given upfront.In this review,the major studies in the management of locally advanced rectal cancer will be discussed.In addition,future directions will be considered such as the role of immunotherapy and ongoing trials looking at timing of chemotherapy,inclusion of radiation,and nonoperative management. | Trish Millard Paul R Kunk Erika Ramsdale Osama E Rahma | 2016 | World Journal of Gastrointestinal Oncology2016，8，10： | 3 |
| 2 | Macrophnge inflammatory protein-1 alpha expression in interstitial lung disease显示文摘 | Standiford TJ Rolfe MW Kunke L | 1993 | J Immunol1993，151，5： | 1 |
| 3 | 显示文摘 | Bernstein H Payne CM Kunke K | 2004 | Carcinogenesis2004，25，5： | 1 |
| 4 | Perturbation method for the eigenvalue problem of lightly damped systems 显示文摘 | KUNK M K | 1993 | Journal of Sound and Vibration1993，160，2： | 1 |
| 5 | Catalytic conversion of biomass to monofunetional hydro- carbons and targeted liquid-fuel classes 显示文摘 | KUNKES E L SIMONETTI D A WEST R M | 2008 | Seienee2008，322，： | 1 |
| 6 | 查看详情显示文摘 | Kunkes E L Simonetti D A West R M | | 0，，： | 1 |
| 7 | Catalytic conversion of biomass to monofunctional hydrocarbons and trageted liquid-fuel classes显示文摘 | Kunkes E L Simonetti D A West R M | 2008 | Science2008，322，17： | 1 |
| 8 | The chronic con- sequences of severe sepsis显示文摘 | Benjamim CF Hogaboam CM Kunke| SL | 2004 | J Leukoc Biol2004，75，3： | 1 |
| 9 | Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes显示文摘 | Kunkes E L Simonetti D A West R M | 2008 | Science2008，322，5900： | 1 |
| 10 | 查看详情显示文摘 | West R M Kunkes E L Simonetti D A | | 0，，： | 1 |
| 11 | Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes 显示文摘 | Kunkes E L Simonetti D A Dumesic J A | 2008 | Science2008，322，： | 1 |
| 12 | Ciprofloxacin resistant in epidemic methicillin-resistant Staphylococcus aureurs 显示文摘 | Issacs R D Kunke P I Cohen R L | 1998 | Lancet1998，1，8585： | 1 |
| 13 | Luminescent metal complexes: Diversity of excited states显示文摘 | VOGLER A KUNKELY H | 2001 | Topics in Current Chemistry2001，213，： | 1 |
| 14 | Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes显示文摘 | Kunkes E L Simonetti D A West R M | 2008 | Science2008，322，5900： | 1 |
| 15 | Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors显示文摘 | Kunke D Grimm D Denger S | 2000 | Cancer Gene Ther2000，7，5： | 1 |
| 16 | Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes 显示文摘 | Kunkes E L Simonetti D A West R M | 2008 | Science2008，322，5900： | 1 |
| 17 | Vapour-phase C-C coupling reactions of biomass-derived oxygenates over Pd/CeZrOx catalysts显示文摘 | Kunkes E L Gurbuz E I Dumesic J A | 2009 | J Catal2009，266，2： | 1 |
| 18 | Optical metal-to-ligand charge transfer in tris (pyrazine-2-carboxylato) cerium (Ⅲ): Absorption and emission 显示文摘 | KUNKELY H VOGLER A | 2002 | J Photochem Photobio A: Chem2002，151，1： | 1 |
| 19 | Vapour-phase C-C coupling reactions of biomass-derived oxygenates over Pd/CeZrOx catalysts显示文摘 | E L KUNKES | 2009 | Journal of Catalysis2009，266，2： | 1 |
| 20 | Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes 显示文摘 | Kunkes Edward L Simonetti Dante A West Ryan M | 2008 | Science2008，322，： | 1 |
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