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49篇 您的检索式：作者名="Kumar KR"

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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi显示文摘	Abdullah FE Ahuja KR Kumar H	2013	J Pak Med Assoc2013，63，11：	1
3	State Estimation and Tracking Problems:A Comparison Between Kalman Filter and Recurrent Neural Networks 显示文摘	Kumar Chenna S Yogesh Kr Jain Himanshu Kapoor	2004	Springer-Verlag Berlin Heidelberg2004，，4：	1
4	Critical is- sues related to transfersomes-novel vesicular system 显示文摘	Vinod KR Kumar MS Anbazhagan S	2012	Acta Sci Pol TechnolAliment2012，11，1：	1
5	Transversus abdo- minis plane block using the loss of resistance to air technique显示文摘	KUMAR N SINGH R SHARMA KR	2012	Minerva Anestesiol2012，78，6：	1
6	Estimation of stature from vertebral column length in South Indians 显示文摘	Nagesh KR Pradeep Kumar G	2006	Leg Med (Tokyo)2006，8，5：	1
7	Assessment of high - sensitiv-ity C - reactive protein and lipid levels in healthy adults and patientswith coronary artery disease,with and without periodontitis -- a cross-sectional study显示文摘	Kumar KR Ranganath V Naik R	2014	J Periodontal Res2014，49，6：	1
8	Prevalence and emer- ging resistance of Moraxella catarrhalis in lower respira- tory tract infections in Karachi显示文摘	Abdullah FE Ahuja KR Kumar H	2013	J Pak Med Assoc2013，63，11：	1
9	Influence of lumen shape and vessel geometry on plaque stresses:possible role in the increased vulnerability of a remodelled vessel and the'shoulder'of a plaque显示文摘	Kumar RK Balakrishnan KR	2005	Heart2005，91，11：	1
10	Evidence of secular variations in Indian monsoon rainfall-circulation relationships显示文摘	PARTHASARATHY B KUMAR KR MUNOT AA	1991	Journal of Climate1991，4，9：	1
11	Evidence for the association of synaptotagmin with glutathione S-transferases:implications for a novel function in human breast cancer显示文摘	Sreenath AS Kumar KR Reddy GV	2005	Clin Biochem2005，38，5：	1
12	Unu-sual nail pigmentation following oyclophos-phamide-containing chemotherapy regimen显示文摘	Kumar S Dixit KR Karmakar S	2010	Indian J Pharmacol2010，42，4：	1
13	Antioxidant status in chil- dren with homozygous - thalassemia 显示文摘	Dhawan V Kumar KR Marwaha RK	2005	Iindian Pediatrics2005，42，17：	1
14	Prevalence and correlates of serostatus disclosure in HIV-infected adults attending the follow up and treatment clinic in Barbados 显示文摘	Kumar A Kilaru KR Forde S	2007	Social Medicine2007，2，2：	1
15	Synthesis of novel isoxazolidine derivatives and studies for their antifungal properties 显示文摘	Ravi Kumar KR Mallesha H Basappa RKS	2003	Eur J Med Chem2003，38，：	1
16	Multimodel superensemble forecasting of tropical cyclones in the Pacific显示文摘	KUMAR TSVV KR/SHNAMURTI TN	2003	Mon Wea Rev2003，131，3：	1
17	Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi显示文摘	Abdullah FE Ahuja KR Kumar H	2013	Pak Med Assoc2013，63，11：	1
18	Improving outcomes and reducing costs by modular training in infection control in a re- source-limited setting显示文摘	Singh S Kumar RK Sundaram KR	2012	Int J Qual Health Care2012，24，6：	1
19	Antioxidant status in children with homozygous 13 - thalassemia 显示文摘	Dhawan V Kumar KR Marwaha RK	2005	Indian Pediatrics2005，42，17：	1
20	Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesi- genic dyskinesia caused by PRRT2 mutations 显示文摘	Schmidt A Kumar KR Redyk K	2012	Arch Neu- rol2012，69，5：	1

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