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| 1 | Metallothionein:An overview显示文摘Metallothioneins (MTs) were discovered in 1957 by Margoshes and Vallee and identified as low-molecular weight and sulphydryl rich proteins. It is not surprising that most mammalian tissues contain age related basal levels of MTs since they are involved in metalloregulatory processes that include cell growth and multiplication. In an effort to understand the biology of this intriguing tumor, various biomarkers such as oncogenes, p53 tumor suppressor gene, waf 1 protein, proliferating cell nuclear antigen, telomerase, microsatellite markers and cytogenetic changes have been examined. One biomarker which has recently shown to be expressed in various human tumors but still less reported in carcinoma is MT. Immunohistochemical detection of MT proteins in cold acetone-fixed paraffin embedded liver sections was performed by the streptavidin-avidin-biotin immuno- peroxidase complex method. | N Thirumoorthy KT Manisenthil Kumar A Shyam Sundar L Panayappan Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials显示文摘Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells(MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases. | Sonia Labrador-Velandia María Luz Alonso-Alonso Sara Alvarez-Sanchez Jorge González-Zamora Irene Carretero-Barrio José Carlos Pastor Iván Fernandez-Bueno Girish Kumar Srivastava | 2016 | World Journal of Stem Cells2016，8，11： | 5 |
| 3 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 4 | A lupane derivative and the 13C-NMR chemical shifts lupanone from Pleurostylia opposita 显示文摘 | Dantanarayana A P Kumar N S | 1982 | Phytochemistry1982，21，8： | 2 |
| 5 | Use of APHRODITE Rain Gauge-Based Precipitation and TRMM 3B43 Products for Improving Asian Monsoon Seasonal Precipitation Forecasts by the Superensemble Method显示文摘 | Yatagai Akiyo Krishnamurti T N Kumar Vinay Mishra A K Simon Anu | 2014 | Journal of Climate2014，，3： | 2 |
| 6 | Structural and electrochemical properties of micro-porous polymer blend electrolytes based on P (VDF-HFP) PAN for Li-ion battery applications 显示文摘 | A Subramania N T Kalyana G Vijaya Kumar | 2006 | Journal of Power Soure2006，153，1： | 1 |
| 7 | Performance of a magnesium-lithium alloy as an anode for magnesium batteries显示文摘 | SIVASHANMUGAM A KUMAR T P RENGANATHAN N G | 2004 | J Appl Electrochem2004，34，： | 1 |
| 8 | Combretastatin A-4 analogs as anticancer agents显示文摘 | Chaudhary A Pandeya S N Kumar P | 2007 | Mini Rev Med Chem2007，7，12： | 1 |
| 9 | Synthesis of novel Ag modified MCM-41 mesoporous molecular sieve and beta zeolite catalysts for ozone decomposition at ambient temperature显示文摘 | Kumar N Konova P M Naydenov A | 2004 | Catalysis Lett2004，98，1： | 1 |
| 10 | DNA barcodes can distinguish species of Indian mosquitoes (Diptera: Culicidae)显示文摘 | Kumar N P Rajavel A R Natarajan R | 2007 | J Med Entomol2007，44，1： | 1 |
| 11 | Phytoremediation:anovel strategy for the removal of toxic metals from the environment using plants显示文摘 | SALT D E BLAYLOCK M KUMAR N P B A | 1995 | Nature Biotechnology1995，13，5： | 1 |
| 12 | Anemia and hematoma volume in acute intracerebral hemorrhag显示文摘 | Kumar M A Rost N S Snider R W | 2009 | Crit Care Med2009，37，5： | 1 |
| 13 | In vitro and in vivo studies on the antioxidant activity of fish peptide isolated from the croaker (Otolithes ruber)muscle protein hydrolysate 显示文摘 | Nazeer R A Kumar N S Jai G R | 2012 | Peptides2012，35，2： | 1 |
| 14 | Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculo us nonfunctioning kidneys显示文摘 | Hemal A K Gupta N P Kumar R | 2000 | J Urol2000，164，1： | 1 |
| 15 | On the performance of stabilized a-nickel hydroxide as a nickel-positive electrode in alkaline storage batteries 显示文摘 | KUMAR V G MUNICHANDRAIAH N KAMATH P V SHUKLA A K | 1995 | Journal of Power Sources1995，56，： | 1 |
| 16 | Chitosan chemistry and pharmaceutical perspectives 显示文摘 | KUMAR M N MUZZARELLI R A MUZZARELLI C | 2004 | ChemRev2004，104，12： | 1 |
| 17 | Differential expres-sion of three members of the AMT1 gene family encoding putativehigh-affinity NH4+ transporters in roots of Oryza sativa subspeciesindica显示文摘 | KUMAR A SILIM S N 0KAM0T0 M | 2003 | Plant Cell and Environment2003，26，6： | 1 |
| 18 | Cephalosporin-resistant Shi- gella flexneri over 9 years ( 2001-09 ) in India 显示文摘 | Taneja N Mewara A Kumar A | 2012 | J Antimicreb Chemother2012，67，6： | 1 |
| 19 | Thermochemistry and aqueous solubilities of hydrotalcitelike solids显示文摘 | Rama Kumar A Alexandra N Hillary T B William H C | | 0，，5568： | 1 |
| 20 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
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