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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Photoreduction of Fe(Ⅲ) by hydroxyl carboxylic acid in seawater显示文摘 | Kuma K Nakabayashi S Matsunaga K | | 0，，6： | 1 |
| 3 | Optimized LiFePO4 for lithium battery cathodes显示文摘 | Yamada A S Chung C Hino Kuma K | 2001 | J Eleetroehem Soc2001，148，3： | 1 |
| 4 | Autophagy is essential for preimplantation development of mouse embryos显示文摘 | Tsukamoto S Kuma A Murakami M | 2008 | Science2008，321，5885： | 1 |
| 5 | Binding of 14-3-3β but not 14-3-3σ controls the cytoplasmic localization of CDC25B:binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B显示文摘 | Uchida S Kuma A Ohtsubo M | 2004 | Journal of Cell Science2004，117，14： | 1 |
| 6 | Cytologic features of hyalinzing trabecular adenoma of the thyroid显示文摘 | Kuma S Hirokawa M Miyauchi A | 2003 | Acta Cytol2003，47，3： | 1 |
| 7 | TiO2-SiO2 and V2O5/TiO2-SiO2 catalyst: Physico-chemical characteristics and catalytic behavior in selective catalytic reduction of NO by NH3显示文摘 | KOBAYASHI M KUMA R MASAKI S SUGISHIMA N | 2005 | Appl Catal B: Environ2005，60，34： | 1 |
| 8 | Granulocyte colony - stimulating factor (G- CSF) does not improve recovery from antithyroid drug - induced agranulocytosis : a prospective study 显示文摘 | FUKATA S KUMA K SUGAWARA M | 1999 | Thyroid1999，9，1： | 1 |
| 9 | Morules in cribriformmorular variant of papillary thyroid carcinoma: lmmunohistochemical characteristics and distinction from squamous metaplasia 显示文摘 | Hirokawa M Kuma S Miyauchi A | 2004 | APMIS2004，112，45： | 1 |
| 10 | Optimized LiFePO4 for lithium battery cathodes显示文摘 | Yamada A S Chung C Hino Kuma K | 2001 | J Electrochem Soc2001，148，3： | 1 |
| 11 | Angiotensin II-induced growth of vascular smooth muscle cells is associated with modulation of cell surface area and platelet-derived growth factor receptor expression 显示文摘 | Kuma S Oki E Onohara T | 2007 | Clin Exp Pharmacol Physiol2007，34，3： | 1 |
| 12 | TiO2-SiO2 and V2O5/TiO2-SiO2 catalyst: physico-chemical characteristics and catalytic behavior in selective catalytic reduction of NO by NH3 显示文摘 | Kobayashi M Kuma R Masaki S Sugishima N | 2005 | Applied Catalysis B: Environmental2005，60，： | 1 |
| 13 | Granulocyte colonystimulating factor (G-CSF)dose not improve recovery from antithyroid drug-induced agranulocytosis:a prospective study 显示文摘 | Fukata S Kuma K Sugawara M | 1999 | Thyroid1999，9，1： | 1 |
| 14 | Colorectal cancer in the young: trends, characteristics and outcome 显示文摘 | GANAPATHI S KUMA D KATSOULAS N | 2011 | Int J Colorectal Dis2011，26，7： | 1 |
| 15 | A stochastic cellular automata model of innovation diffusion显示文摘 | Bhargava S C Kuma A | 1992 | Technological Forecasting and Social Change1992，44，： | 1 |
| 16 | Factors affecting quality of dried low-rank coals显示文摘 | Karthikeyan M Kuma J V M Hoe C S | | 0，，10： | 1 |
| 17 | A stochastic cellular automatamodel of innovation diffusion 显示文摘 | Bhargava S C Kuma A A | 1992 | Technological Forecasting and Social Change1992，44，： | 1 |
| 18 | Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy显示文摘 | Saini A K Kuma H S A Sharma S S | | 0，，： | 1 |
| 19 | A stochastic cellular automata model of innovation diffusion显示文摘 | Bhargava S C Kuma A | 1993 | Technological Forecasting and Social Change1993，44，： | 1 |
| 20 | Vortical flow structure and loss generation process in a transonic centrifugal compressor impeller显示文摘 | IBARAKI S MATSUO T KUMA H | 2007 | ASME Paper2007，27，791： | 1 |
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