|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Optimized LiFePO4 for lithium battery cathodes显示文摘 | Yamada A S Chung C Hino Kuma K | 2001 | J Eleetroehem Soc2001，148，3： | 1 |
| 3 | Optimized LiFePO4 for lithium battery cathodes显示文摘 | Yamada A S Chung C Hino Kuma K | 2001 | J Electrochem Soc2001，148，3： | 1 |
| 4 | A stochastic cellular automata model of innovation diffusion显示文摘 | Bhargava S C Kuma A | 1992 | Technological Forecasting and Social Change1992，44，： | 1 |
| 5 | Factors affecting quality of dried low-rank coals显示文摘 | Karthikeyan M Kuma J V M Hoe C S | | 0，，10： | 1 |
| 6 | A stochastic cellular automatamodel of innovation diffusion 显示文摘 | Bhargava S C Kuma A A | 1992 | Technological Forecasting and Social Change1992，44，： | 1 |
| 7 | A stochastic cellular automata model of innovation diffusion显示文摘 | Bhargava S C Kuma A | 1993 | Technological Forecasting and Social Change1993，44，： | 1 |
| 8 | Purification and characterization of an extracellular polysaccharide from haloakalo pholic Bacillus 显示文摘 | Kuma C Joo H Choi J | 2004 | Enzyme and Microbial Technology2004，34，7： | 1 |
| 9 | A stochastic cellular automatamodel of innovation diffusion 显示文摘 | Bhargava S C Kuma A | 1992 | Technological Forecasting and Social Ciange1992，44，： | 1 |
| 10 | Optimized LiFePO4 for lithium battery cathodes显示文摘 | Yamada A S Chung C Hino Kuma K | 2001 | J Electrochem Soc2001，148，3： | 1 |
| 11 | A stochastic cellular automata model of innovation diffusion显示文摘 | BHARGAVA S C KUMA A | 1993 | Technological Forecasting and Social Change1993，44，： | 1 |
| 12 | Non radiating edges and four edges gapcoupled multiple resonator broad-band microstrip antenna显示文摘 | KUMA G GUPTA K C | 1985 | IEEE Transactions on Antennas and Propagation1985，，33： | 1 |
| 13 | Intact newborn survival af- ter spontanoous umbilical cord vascular rapture before labor显示文摘 | Kuma RA Kaplan C Mokrian S | 2012 | Obstet Gyecol2012，120，22： | 1 |
| 14 | Microbial proteases in peptide synthesis: approaches and applications显示文摘 | KUMAE R D BHALLA T C | 2005 | Applied Microbiology and Biotechnology2005，68，6： | 1 |
| 15 | Efficacy of electrolyzed oxidizing water for inactivating Escherichia coli O157:H7,Salmonella enteritidis,and Listeria monocytogenes显示文摘 | KUMA S V GABRIEL O E HUNG Y C | 1999 | Applied and Environmental Microbiology1999，65，9： | 1 |
| 16 | A Stochastic Cellular Automata Model of Innovation Diffusion 显示文摘 | Bhargava S C Kuma A | 1993 | Technological Forecasting and Social Change1993，，44： | 1 |
| 17 | 1-450 显示文摘 | Kuma C Joo H Choi J Purification and characterization of an extracellular polysaccharide from haloakalopholic Bacillus sp | 2004 | Enzyme and Microbial Technology2004，34，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员