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| 1 | Woofer–tweeter adaptive optical structured illumination microscopy显示文摘A woofer–tweeter adaptive optical structured illumination microscope(AOSIM) is presented. By combining a low-spatial-frequency large-stroke deformable mirror(woofer) with a high-spatial-frequency low-stroke deformable mirror(tweeter), we are able to remove both large-amplitude and high-order aberrations. In addition, using the structured illumination method, as compared to widefield microscopy, the AOSIM can accomplish highresolution imaging and possesses better sectioning capability. The AOSIM was tested by correcting a large aberration from a trial lens in the conjugate plane of the microscope objective aperture. The experimental results show that the AOSIM has a point spread function with an FWHM that is 140 nm wide(using a water immersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm peak-to-valley wavefront error with 2.05 μm RMS aberration). After structured light illumination is applied, the results show that we are able to resolve two beads that are separated by 145 nm, 1.62× below the diffraction limit of 235 nm. Furthermore, we demonstrate the application of the AOSIM in the field of bioimaging. The sample under investigation was a green-fluorescentprotein-labeled Drosophila embryo. The aberrations from the refractive index mismatch between the microscope objective, the immersion fluid, the cover slip, and the sample itself are well corrected. Using AOSIM we were able to increase the SNR for our Drosophila embryo sample by 5×. | QINGGELE LI MARC REINIG DAICH KAMIYAMA BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY | 2017 | Photonics Research2017，5，4： | 3 |
| 2 | Role of claudin in tumorigenesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Advanced Drug Delivery Reviews2005，57，6： | 1 |
| 3 | Genomic organization of Claudin-1 and its assessment in hereditary and sporadic breast cancer显示文摘 | KRAMER F WHITE K KUBBIES M | 2000 | Human Genetics2000，107，3： | 1 |
| 4 | Role of claudins in tumorigenesis显示文摘 | Swisshelm K Macek R Kubbies M | | 0，，06： | 1 |
| 5 | High resolution analysis of cell cycle correlated vimentin expression in asynchronously grown, TPA- treated MPC-11 cells by the novel flow cytometric multiparameter BrdU Hoechst/PI and immunolabeling technique显示文摘 | Giese G Kubbies M Traub P | 1994 | J Cell Physiol1994，161，2： | 1 |
| 6 | Role of claudins in tumorigenesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 7 | Role of Claudins in tumori- genesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Advanced Drug Delivery Reviews2005，57，6： | 1 |
| 8 | Role of claudins in tumorigenesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 9 | Cell cycle analysis of asynchronous cell populations by flow cytometry using bromide oxyuridine label and Hoechst propidium iodide stain显示文摘 | Ormerod MG Kubbies M | | Cytometry0，13，： | 1 |
| 10 | Role of Claudins in tu- morigenesis 显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Advanced Drug Delivery Reviews2005，57，6： | 1 |
| 11 | Role of claudins in tumori-genesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 12 | Decreased oxygen supply enhances growth in culture oF human mid-trimester amniotic Fluid cells 显示文摘 | BRACKERTZ M KUBBIES M FEIGE A | 1983 | Hum Genet1983，64，4： | 1 |
| 13 | Rapid generation of single-tumor sp- heroids for high-throughput cell function and toxicity analy- sis 显示文摘 | Ivascu A Kubbies M | 2006 | J Biomol Screen2006，11，8： | 1 |
| 14 | Role of claudins in tumorigenesis 显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 15 | Role of claudins in tumorigenesis 显示文摘 | Swissheil K Macek R Kubbies | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 16 | Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer显示文摘 | Kramer F White K Kubbies M | 2000 | Hum Genet2000，107，3： | 1 |
| 17 | Role of claudins in tumori-genesis显示文摘 | Swisshelm K Macek R Kubbies M | 2005 | Adv Drug Deliv Rev2005，57，6： | 1 |
| 18 | A porous silicon based microarray for label-free optical detection of DNA hybridization显示文摘 | Kubby J A Rea I Coppola G | 2010 | SPIE2010，7606，： | 1 |
| 19 | Genomic organization of landin-1 and its assessment in hereditary and sporadic breast canc-er显示文摘 | Kramer F White K Kubbies M | 2000 | Ham Genet2000，107，3： | 1 |
| 20 | Genomic organization of Claudin - 1 and its assessment in hereditary and sporadic breast cancer显示文摘 | Kramer F White K Kubbies M | 2000 | Human Genetics2000，107，： | 1 |
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