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| 1 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 2 | Surgical recurrence in Crohn's disease: Are we getting better?显示文摘Crohn's disease(CD) still remains a challenging chronic inflammatory disorder, both for colorectal surgeons and gastroenterologists. The need for recurrent surgery following primary intestinal resection is still considerable, though recent evidence suggested a declining rate of recurrence. Several conflicting surgical parameters have been identified that might impact on the postoperative outcome positively, such as access to the abdomen, anastomotic configuration or type of disease. Additionally, promising results have been achieved with the increased use of immunosuppressive medications in CD. Consequently, the question arises if we are getting better as a result of novel medical and surgical strategies. | Ivan Kristo Anton Stift Michael Bergmann Stefan Riss | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 3 | Physical properties of starch nanocrystal-reinforced pullulan films显示文摘 | Eleana Kristo Costas G. Biliaderis | 2006 | Carbohydrate Polymers2006，，： | 1 |
| 4 | The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis 显示文摘 | LEKVA T BOLLERSLEV J KRISTO C | 2010 | J Clin Endocrinol Metab2010，95，1： | 1 |
| 5 | Effects of Low and High Plasma Concentrations of Dexmedetomidine on Myocardial Perfusion and Cardiac Function in Healthy Male Subjects显示文摘 | Amir Snapir Jussi Posti Erkki Kentala Juha Koskenvuo Jan Sundell Helena Tuunanen Kristo Hakala Harry Scheinin Juhani Knuuti Mika Scheinin | 2006 | Anesthesiology2006，，5： | 1 |
| 6 | Clinical guideline for the evaluation, management and long-term care of obstructive sleepapnea in adults显示文摘 | Epstein LJ Kristo D Strollo P J | 2009 | J Clin Sleep Med2009，5，3： | 1 |
| 7 | Water vapour bar- tier and tensile properties of composite caseinate-pullulan films:biopolymer composition effects and impact of bees- wax lamination 显示文摘 | Kristo E Biliaderis C G Zamprake A | 2007 | Food Chemistry2007，101，2： | 1 |
| 8 | Acute adenosine preconditioning is mediated by p38MAPK activation in discrete subcellular compartments显示文摘 | Ballard-Croft C Kristo G Yoshimura Y | 2005 | Am J Physiol2005，288，3： | 1 |
| 9 | Herbal remedies of Solidago-correlation of phytochemical characteristics and antioxidant properties显示文摘 | APATI P SZENTMIHALYI K KRISTO S T | | 0，，04： | 1 |
| 10 | Analysis of Antioxidant Flavonoids from Asteraceae and Moraceae Plants by Capillary Electrophoresis 显示文摘 | Kristo Sz T Ganzler K Apati P | 2002 | Chromatographia2002，56，： | 1 |
| 11 | MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis 显示文摘 | Najafi-Shoushtari SH Kristo F Li Y | 2010 | Science2010，328，5985： | 1 |
| 12 | Clinical guideline forthe evaluation, management and longterm care of obstructiresleep apnea in adults显示文摘 | Epstein LJ Kristo D Strollo VJ | 2009 | J Clin Sleep Med2009，5，3： | 1 |
| 13 | Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture 显示文摘 | King VL Lin AY Kristo F | 2009 | Circulation2009，119，3： | 1 |
| 14 | Water sorption and thermo-mechanical properties of water/sorbitol-plasticized composite biopolymer films: Caseinate-pullulan bilayers and blends显示文摘 | KRISTO E BILIADERIS C G | 2006 | Food Hydrocolloids2006，20，7： | 1 |
| 15 | Clinical guideline for the evaluation, management and long-term care of obstructive sleep ap- nea in adults 显示文摘 | Epstein LJ Kristo D Strollo PJ Jr | 2009 | J Clin Sleep Med2009，5，3： | 1 |
| 16 | Evaluation of boronic acid disk tests for differentiating KPC-possessing Kleb- siella pneumoniae isolates in the clinical laboratory 显示文摘 | Tsakris A Kristo I Poulou A | 2009 | J Clin Microbiol2009，47，2： | 1 |
| 17 | Clinical guideline for tile evaluation, management and long-term care of ob- structive sleep apnea in adults显示文摘 | Epstein LJ Kristo D Strollo PJ Jr | 2009 | J Clin Sleep Med2009，5，3： | 1 |
| 18 | Clinical guideline for the evaluation,management and long-term care of obstructive sleep apnea in adults显示文摘 | Epstein LJ Kristo D Strollo PJ | 2009 | J Clin Sleep Med2009，5，： | 1 |
| 19 | MiRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis显示文摘 | Najafi SH Kristo F Li Y | | 0，，5985： | 1 |
| 20 | Paranasal sinus findings in children during respiratory infection evaluated with magnetic resonance imaging显示文摘 | Kristo A Uhari M Luotonen J | 2003 | Pediatrics2003，111，5： | 1 |
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