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| 1 | Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India显示文摘AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P < 0.001, odds ratio (OR) 8.20; 95% confidence interval (95% CI), 4.08-16.47] and PUD (77.4% vs 31.1%, P < 0.001; OR 8.04; 95% CI, 3.25-19.90). Risk of gastric adenocarcinoma was significantly higher in patients having C carrier with (OR 7.83; 95% CI 3.09-19.85) and without H pylori infection (OR 7.06; 95% CI, 2.61-19.09). Patients with C carrier and H pylori infection had significant risk for the development of PUD (P < 0.001; OR 5.65; 95% CI, 2.07-15.34). CONCLUSION: -765G > C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD. | Ashish Saxena Kashi Nath Prasad Uday Chand Ghoshal Monty Roshan Bhagat Narendra Krishnani Nuzhat Husain | 2008 | World Journal of Gastroenterology2008，14，10： | 18 |
| 2 | Early gallbladder cancer显示文摘 | Wagholikar GD Behari A Krishnani N | 2002 | J Am Coll Surgeon2002，194，5： | 1 |
| 3 | Predictors of long-term survival in patients with gallbladder cancer 显示文摘 | Balachandran P Agarwal S Krishnani N | 2006 | J Gastrointest Surg2006，10，6： | 1 |
| 4 | Early gallbladder cancer显示文摘 | Wagholikar GD Behari A Krishnani N | | 0，，02： | 1 |
| 5 | Early gallbladder cancer显示文摘 | Wagholikar GD Behari A Krishnani N | 2002 | J Am Coll Surg2002，194，2： | 1 |
| 6 | Abundance of sulphur-oxidizlng bacteria in coastal aquaculture using soxB gene analyses显示文摘 | Krishnani K K Gopikrishna G Pillai S M | 2010 | Aquaculture Research2010，41，9： | 1 |
| 7 | Profile of liver involvement in dengue virus infection显示文摘 | Itha S Kashyap R Krishnani N | 2005 | Natl Med J India2005，18，3： | 1 |
| 8 | Biosorption mechanism of nine different heavy metals onto biomatrix from rice husk显示文摘 | Krishnani KK Meng XG Christodoulatos C | 2008 | Journal of hazardous materials2008，153，3： | 1 |
| 9 | Early gallbladder cancer显示文摘 | Behari A Krishnani N | 2002 | J Am Coll Surg2002，194，： | 1 |
| 10 | Bactericidal and ammonia removal activity of silver ion-exchanged zeolite 显示文摘 | Krishnani KK Zhang Y Xiong L | 2012 | Bioresour Technol2012，117，： | 1 |
| 11 | Cure for immune‐tolerant hepatitis B in children: is it an achievable target with sequential combo therapy with lamivudine and interferon?显示文摘 | U. Poddar S. K. Yachha J. Agarwal N. Krishnani | 2012 | J Viral Hepat2012，，5： | 1 |
| 12 | Fine needle aspiration cytology in xanthogranulomato cholecystitis, gallbladder adenocarcinoma and coexis lesions显示文摘 | Krishnani N Shukla S Jain M etal | 2000 | Acta Cytol2000，44，4： | 1 |
| 13 | Prevalence of RET/PTC expression in papillary thyroid carcinoma and its correlation with prognostic factors in a north Indian popula- tion显示文摘 | Mishra A Agrawal V Krishnani N | 2009 | J Postgrad Med2009，55，3： | 1 |
| 14 | Bactericidal and ammonia removal activity of silver ion-exchanged zeolite显示文摘 | K.K. Krishnani Yu Zhang Laj Xiong Yushan Yan Raj Boopathy Ashok Mulchandani | 2012 | Bioresource Technology2012，，： | 1 |
| 15 | Dubin-Johnson syndrome-a clinicopatholagic study of twenty cases 显示文摘 | Rastogi A Krishnani N Pandey R | 2006 | Indian J Pathol Microbiol2006，49，4： | 1 |
| 16 | Prevalence of RET/ PTC expression in papillary thyroid carcinoma and its correlation with prognostic factors in a north Indian population 显示文摘 | Mishra A Agrawal V Krishnani N | 2009 | J Post- grad Med2009，55，3： | 1 |
| 17 | An insufficient anti - inflammatory cytokine response in mouse brain is associated with increased tissue pathology and viral load during Japanese encephalitis virus infection显示文摘 | Saxena V Mathur A Krishnani N | 2008 | Archives of Virology2008，153，2： | 1 |
| 18 | Bactericidal and ammonia removal activity of silver ion-exchanged zeolite显示文摘 | Krishnani K K Zhang Yu Yan Yushan | | 0，，： | 1 |
| 19 | Fine needle aspira-tion cytology in xanthogranulomatous cholecystitis,gallblad-der adenocarcinoma and coexistent lesions显示文摘 | Krishnani N Shukla S Jain M | 2000 | Acta Cytol2000，44，4： | 1 |
| 20 | Early gallbladder cancer显示文摘 | Wagholikar GD Behari A Krishnani N | 2002 | J Am Coll Surg2002，194，2： | 1 |
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