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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 3 | The M/G/1 retrial queue with feedback and starting failures显示文摘 | Krishna Kumar B Pavai S Madheswari Vijayakumar A | 2002 | Applied Mathematical Modelling2002，，26： | 1 |
| 4 | 1-Hexene isomerization and n-hexane cracking over HMCM-22显示文摘 | ANUP K T KRISHNA G B TOSHIHIDE B | 2001 | Applied Catalysis A:General2001，213，2： | 1 |
| 5 | pb( II ) uptake by kaolinite and montorrillonite in aqueous medium显示文摘 | Krishna G B Susmita S G | 2006 | Colloids and Surfaces A2006，277，13： | 1 |
| 6 | Comparison of wavelet based ANN and regression models for reservoir inflow forecasting 显示文摘 | Krishna B | 2014 | Journal of Hydrologic Engineer-ing2014，19，7： | 1 |
| 7 | An M/G/1 retrial queueing system with two-phase service and preemptive resume显示文摘 | Krishna Kumar B Vijaykumar A | 2002 | Annals of Operations Research2002，113，： | 1 |
| 8 | Per- vaporation separation of water+1,4-dioxane and water+ tetrahydrofuran mixtures using sodium alginate and its blend membranes with hydroxyethylcellulose :A com- parative study显示文摘 | Naidu B V K Krishna R K S V Aminabhavi T M | 2005 | Journal of Membrane Science2005，260，12： | 1 |
| 9 | Low stiffness porous Ti structures for load-bearing implants 显示文摘 | Krishna B V Bose S Bandyopadhyay A | 2007 | Acta Biomaterialia2007，3，6： | 1 |
| 10 | Surfactant-modified clay as adsorbent for chromate显示文摘 | B S Krishna D S R Murty | 2001 | Applied Clay Science2001，，20： | 1 |
| 11 | Characterization of starches of proso,foxtail,barnyard,kodo,and little millets显示文摘 | Krishna Kumari S Thayumanavan B | 1998 | Plant Foods for Human Nutrition1998，53，： | 1 |
| 12 | Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms显示文摘 | Shen SS Krishna B Chirala R | 2005 | Mod Pathol2005，18，： | 1 |
| 13 | Ribosomal protein L11 negatively regulates oneoprotein MDM2 and Mediales a p53-Dependenl Ribosomal-Stress checkpoint pathway 显示文摘 | Zhang YP Gabrielle WW Krishna B | 2003 | Molecular and Cellular Biology2003，23，23： | 1 |
| 14 | Influence of Microarc Oxidation and Hard Anodizing on Plain Fatigue and Fretting Fatigue Behaviour of Al-Mg-Si Alloy显示文摘 | RAJASEKARAN B GANESH SUNDARA RAMAN S RAMA KRISHNA L | 2008 | Surface and Coatings Technology2008，202，8： | 1 |
| 15 | Permutation Entropy Based Real-Time Chatter Detection Using Audio Signal in Turning Process显示文摘 | Nair U Krishna B M Namboothiri V N N | | 0，，01： | 1 |
| 16 | Fabrication of compositionally and structurally graded Ti-TiO2 structures using laser engineered net shaping ( LENS ) 显示文摘 | Vamsi Krishna B Balla V K | 2009 | Acta Biomaterialia2009，5，： | 1 |
| 17 | Assimilative capacity and dispersion of pollutants due to industrial sources in Visakhapatnam bowl area显示文摘 | RAMA KRISHNA T V B P S REDDY M K REDDY R C | 2004 | Atmospheric Environment2004，38，39： | 1 |
| 18 | Stereoselective Synthesis of1-Methyl-3′,4′,5′,6′-tetrahydrospiro-2-one Derivatives via Prins Cyclization显示文摘 | Krishna D Yu B C Wang B H | 2015 | J Org Chem2015，80，11： | 1 |
| 19 | Radia- tion,radicals, and images 显示文摘 | Mitchell J B Russo A Krishna M C | 2000 | Ann N Y Acad Sci2000，899，1： | 1 |
| 20 | Toxicity and mAChRs binding activity of Cassiopea xamachana venom from Puerto Rican coasts显示文摘 | Faisal FY Laura G Krishna B | 2005 | Toxicon2005，45，： | 1 |
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