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| 1 | Oxidative stress factors in Parkinson's disease显示文摘Parkinson's disease(PD) is the second most common cause of neurodegeneration.Over the last two decades, various hypotheses have been proposed to explain the etiology of PD.Among these is the oxidant-antioxidant theory, which asserts that local and systemic oxidative damage triggered by reactive oxygen species and other free radicals may promote dopaminergic neuron degeneration.Excessive reactive oxygen species formation, one of the underlying causes of pathology in the course of PD has been evidenced by various studies showing that oxidized macromolecules including lipids, proteins, and nucleic acids accumulate in brain tissues of PD patients.DNA oxidation may produce various lesions in the course of PD.Mutations incurred as a result of DNA oxidation may further enhance reactive oxygen species production in the brains of PD patients, exacerbating neuronal loss due to defects in the mitochondrial electron transport chain, antioxidant depletion, and exposure to toxic oxidized dopamine.The protein products of SNCA, PRKN, PINK1, DJ1, and LRRK2 genes are associated with disrupted oxidoreductive homeostasis in PD.SNCA is the first gene linked with familial PD and is currently known to be affected by six mutations correlated with the disorder: A53T, A30P, E46K, G51D, H50Q and A53E.PRKN encodes Parkin, an E3 ubiquitin ligase which mediates the proteasome degradation of redundant and disordered proteins such as glycosylated α-synuclein.Over 100 mutations have been found among the 12 exons of PRKN.PINK1, a mitochondrial kinase highly expressed in the brain, may undergo loss of function mutations which constitute approximately 1–8% of early onset PD cases.More than 50 PD-promoting mutations have been found in PINK1.Mutations in DJ-1, a neuroprotective protein, are a rare cause of early onset PD and constitute only 1% of cases.Around 20 mutations have been found in DJ1 among PD patients thus far.Mutations in the LRRK2 gene are the most common known cause of familial autosomal dominant PD and sporadic PD.Treatment of PD patients, especially in the advanced stages of the disease, is very difficult.The first step in managing progressive PD is to optimize dopaminergic therapy by increasing the doses of dopamine agonists and L-dopa.The next step is the introduction of advanced therapies, such as deep brain stimulation.Genetic factors may influence the response to L-dopa and deep brain stimulation therapy and the regulation of oxidative stress.Consequently, research into minimally invasive surgical interventions, as well as therapies that target the underlying etiology of PD is warranted. | Jolanta Dorszewska Marta Kowalska Michał Prendecki Thomas Piekut Joanna Kozłowska Wojciech Kozubski | 2021 | Neural Regeneration Research2021，16，7： | 7 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | Mortality of therapeutic fish Garra rufa caused by Aeromonas sobria显示文摘Objective:To investigate a case of mass mortality of Garra rufa(G.rufa)from a fish hatchery farm in Slovakia.Methods:Causative bacterial agent was swabbing out of affected fish skin area and subsequently identified using commercial test system.Antibiotic susceptibility was determined by the disk diffusion method.Results:Infected G.rufa was characterized by abnormal swimming behaviour,bleeding of skin lesions and local haemorrhages.Despite of using recommended aquatic antibiotic treatment no improvement was achieved and Aeromonas sobria{A.sobria)was identified as a causative agent of fish mortality.Due to massive fish mortality,antibiotic susceptibility of pure isolated culture of A.sobria was evaluated employing eight antibiotics against human infections.A.sobria was resistant only against one antibiotic,namely ampicilin.Conclusions:These results indicate that A.sobria can act as a primary pathogen of G.rufa and may be a potential risk factor for immunodeficient or immunoincompetent patients during the ichthyotherapy. | Juraj Majtán Jaroslav erny Alena Ofúkaná Peter Taká Milan Kozánek | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 3 |
| 4 | Ribosome-inacti- vating lectins from plants显示文摘 | Koz|ov IuV Sudarkina OIu Kurmanova AG | 2006 | Mol Biol2006，40，4： | 1 |
| 5 | Oblivious spatio-temporal watermarking ofdigital video by exploiting the human visual system显示文摘 | KOZ A ALATAN A A | 2008 | IEEE TransCircuits Syst Video Technol2008，18，3： | 1 |
| 6 | The effect of paclitaxeleluting stents on restenosis 显示文摘 | Kursaklioglu H Koz C Iyisoy A | 2006 | Anadolu Kardiyol Derg2006，6，1： | 1 |
| 7 | Preliminary study of external interatrial muscle fascicles显示文摘 | Koz owski D Kamiński R Piwko G | 2002 | Folia Morphol (Warsz)2002，61，2： | 1 |
| 8 | Effects of resveratrol on blood homocysteine level,on homocysteine induced ox- idative stress,apoptosis and cognitive dysfunctions in rats 显示文摘 | Koz ST Etem EO Baydas G | 2012 | Brain Res2012，1484，： | 1 |
| 9 | Heavy metal analysis around Murgul (Artvin) copper mining area of Turkey using moss and soil显示文摘 | B. Koz U. Cevik S. Akbulut | 2012 | Ecological Indicators2012，，： | 1 |
| 10 | Biodegradation of the outer silicone insulation of endocardial leads 显示文摘 | Kotodzifiska A Kutarski A Koz~owska M | 2013 | Circ Arrhythm Electrophysiol2013，6，2： | 1 |
| 11 | Noninvasive ev&lu&tion of kidney hypoxi& &nd fibrosis using m&gnetic reson&nce im&ging显示文摘 | Inoue T Koz&w& E Ok&d& H et &l | 2011 | JournA/ of the Americ&n Society of Nephrology2011，22，8： | 1 |
| 12 | Exercise capacity, arrhythmic risk profile, and pulmonary function is not influenced by intracoronary injection of Bone Marrow Stem Cells in patients with acute myocardial infarction显示文摘 | Ewa Straburzyńska-Migaj Ma?gorzata Popiel Stefan Grajek Agnieszka Katarzyńska-Szymańska Maciej Lesiak Piotr Br?borowicz Krzysztof Sawiński Anna Czy? Lidia Gil Maria Koz?owska-Skrzypczak Mieczys?aw Komarnicki | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 13 | Bioaccumulation and Effects of Heavy Metals in Crayfish: A Review显示文摘 | Antonín Kouba Milo? Bu?i? Pavel Kozák | 2010 | Water Air & Soil Pollution (-)2010，，1： | 1 |
| 14 | A novel benzoxazine monomer with methacrylate functionality and its thermally curable (co)polymers显示文摘 | Koz B Kiskan B Yagci Y | 2011 | Polym Bull2011，66，： | 1 |
| 15 | Substituted amides and hydrazides of dieacboxylic acids显示文摘 | Dolzhenko A V Koz'minykh V O Kolotova N V | 2003 | Pharmacentical Chemistry Journal2003，37，5： | 1 |
| 16 | Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy显示文摘 | Koz'towska L Rydzewski A Fiderkiewicz B | 2010 | J Ren Nutr2010，20，4： | 1 |
| 17 | On becoming a parasite: evaluating wall oxidases in parasitic plant development 显示文摘 | Kim D Koz R Boone L | 1998 | Chem Biol1998，5，： | 1 |
| 18 | Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer显示文摘 | Kozowski M Naumnik W Nikliński J | 2011 | Folia Histochemica et Cytobiologica2011，，01： | 1 |
| 19 | The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients显示文摘 | Koz C Baysan O Yokusoglu M | 2009 | Med Sci Monit2009，15，7： | 1 |
| 20 | Heavy metal analysis around murgul (artvin) copper mining area of turkey using moss and soil显示文摘 | Koz B Cevik U Akbulut S | 2012 | Ecologi- ca/Indicators2012，20，9： | 1 |
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