|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal diseases,with an average 5-year survival rate of less than 10%.Unfortunately,the majority of patients have unresectable,locally advanced,or metastatic disease at the time of diagnosis.Moreover,traditional treatments such as chemotherapy,surgery,and radiation have not been shown to significantly improve survival.Recently,there has been a swift increase in cancer treatments that incorporate immunotherapybased strategies to target all the stepwise events required for tumor initiation and progression.The results in melanoma,non-small-cell lung cancer and renal cell carcinoma are very encouraging.Unfortunately,the application of checkpoint inhibitors,including anti-CTLA4,anti-PD-1,and anti-PD-L1 antibodies,in pancreatic cancer has been disappointing.Many studies have revealed that the PDAC microenvironment supports tumor growth,promotes metastasis and consists of a physical barrier to drug delivery.Combination therapies hold great promise for enhancing immune responses to achieve a better therapeutic effect.In this review,we provide an outline of why pancreatic cancer is so lethal and of the treatment hurdles that exist.Particular emphasis is given to the role of the tumor microenvironment,and some of the latest and most promising studies on immunotherapy in PDAC are also presented. | Panagiotis Sarantis Evangelos Koustas Adriana Papadimitropoulou Athanasios G Papavassiliou Michalis V Karamouzis | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 4 |
| 2 | Upgraded role of autophagy in colorectal carcinomas显示文摘Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients. | Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis V Karamouzis | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 3 |
| 3 | The neural rep-resentation of abstract words: The role of emotion 显示文摘 | Vigliocco G Kousta ST Rosa PAD | 2014 | Ce- rebral Cortex2014，，7： | 1 |
| 4 | Implications ofnew diagnostic criteria for abnormal gluoose homeostasisin women with previous gestational diabetes显示文摘 | Kousta E Lawrence NJ Penny A | 1999 | Diabetescare1999，22，6： | 1 |
| 5 | On the fisher effect 显示文摘 | Koustas Z Serletis A | 1999 | Journal of Monetary Economics1999，44，： | 1 |
| 6 | The prevalence of polycystic ovaries in women with a history of gestational diabetes显示文摘 | Kousta E Cela E Lawrence N | 2000 | Clin Endocrinol2000，53，： | 1 |
| 7 | Modern use of clomiphene citrate in induction of ovulation显示文摘 | KOUSTA E WHITE D M FRANKS S | | 0，，04： | 1 |
| 8 | The prevalence of polycystic ovaries in women with a history of gestational diabetes显示文摘 | Kousta E Cela E Lawrence N | 2000 | Clin Endocrinol2000，53，4： | 1 |
| 9 | Implications of new diagnostic critera for abnormal glucose homeostasis irt women with previous gestational diabetes显示文摘 | Kousta E Lawrence NJ Penny A | | 0，，： | 1 |
| 10 | Successful induction of ovulation and completed pregnancy using recombinant luteinizing hormone and follicle stimulation hormone in woman with Kallmann's syndrome 显示文摘 | Kousta E White DM Piazzi A | 1996 | Hum Reprod1996，11，1： | 1 |
| 11 | Rational bubbles or persistent deviations from market fundamentals?显示文摘 | Zisimos Koustas Apostolos Serletis | 2005 | Journal of Banking & Finance2005，，29： | 1 |
| 12 | Successful induction ovulation and completed pregnancy using recombinant human luteinizing hormone and follic le stimulating hormone in a woman with Kallmann's syndrome显示文摘 | White DH Piazzi A | 1996 | Hum Reprod1996，11，1： | 1 |
| 13 | Modern use of clomiphene citrate in induction of ovulation显示文摘 | Kousta E White DM Franks S | 1997 | Hum Reprod Update1997，3，： | 1 |
| 14 | Implications of new diagnostic criteria for abnormal glucose homeostasis in women with previous gestational diabetes显示文摘 | Kousta E Lawrence N J Penny A | 1999 | Diabetes Care1999，22，6： | 1 |
| 15 | Sex determination and disorders of sex development according to the revised nomenclature and classification in 46, XX individuals显示文摘 | Kousta E Papathanasiou A Skordis N | 2010 | Hormones(Athens)2010，9，3： | 1 |
| 16 | The prevalence of poly cystic ovaries in women with a history of gestational diabetes 显示文摘 | Kousta E Cela E Lawrence N | 2000 | Clinical Endocrinology2000，53，4： | 1 |
| 17 | Sex determination and disorders of sex development according to the revised nomenclature and classification in 46, XX individuals 显示文摘 | Kousta E Papathanasiou A Skordis N | 2010 | Hormones (Athens)2010，9，3： | 1 |
| 18 | Women with a history of ges- tational diabetes of European and South Asian origin are shorter than women with normal glucose tolerance in pregnancy显示文摘 | Kousta E Lawrence NJ Penny A | 2000 | Diabet Med2000，17，18： | 1 |
| 19 | Epidemiological charac-teristics of children with autoimmune thyroid disease显示文摘 | Skarpa V Kousta E Tertipi A | | 0，，： | 1 |
| 20 | Treatment with thyroxine reduces thyroid volume in euthyroid children and adolescents with chronic autoimmune thyroiditis 显示文摘 | Scarpa V Kousta E Tertipi A | 2010 | Horm Res Paediatr2010，73，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员