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| 1 | HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination. | Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Numerical optimization using synergetic swarms of foraging bacterial populations显示文摘 | Chatzis S P and Koukas S | 2011 | Expert Systems with Applications2011，38，15： | 1 |
| 3 | Numerical optimization using syn- ergetic swarms of foraging bacterial populations显示文摘 | Chatzis S P Koukas S | 2011 | Expert Systems with Applications2011，38，15： | 1 |
| 4 | Numerical optimization using synergetic swarms of foraging bacterial populations显示文摘 | Chatzis S P Koukas S | 2011 | Expert Systems with Application2011，38，15： | 1 |
| 5 | Numerical optimization using synergetic swarms of foraging bacterial populations显示文摘 | Chatzis S P Koukas S | | 0，，12： | 1 |
| 6 | Numerical optimization using synergetic swarms of foraging bacterial populations 显示文摘 | Chatzis S P Koukas S | 2011 | Expert Systems with Applications2011，38，15： | 1 |
| 7 | Numerical optimization using synergetic swarms of foraging bacterial populations显示文摘 | Chatzis S P Koukas S | 2011 | Expert Systems with Applications2011，38，15： | 1 |
| 8 | Numerical optimization u- sing synergetic swarms of foraging bacterial popula- tions显示文摘 | Chatzis S P Koukas S | 2011 | Expert Syst Appl2011，38，15： | 1 |
| 9 | Developing a lexicon for descriptive analysis of soymilks显示文摘 | Kouka K D Klein B P Lee S Y | 2004 | Journal of Food Science2004，69，7： | 1 |
| 10 | Numerical Optimization Using Syner-getic Swarms of Foraging Bacterial Populations显示文摘 | Chatzis S P Koukas S | | 0，，12： | 1 |
| 11 | Numerical optimization using synergetic swarms of foraging bacterial populations显示文摘 | Chatzisa S P Koukas S | 2011 | Expert Systems with Applications2011，38，15： | 1 |
| 12 | Developing a Lexicon for Descriptive Analysis of Soymilks 显示文摘 | K DAY N' KOUKA B P KLEIN | 2004 | Joumal of Food Science2004，69，7： | 1 |
| 13 | Status of hepatitis C virus vaccination:Recent update显示文摘Hepatitis C virus(HCV) infection is still a major public health problem worldwide since its first identification in 1989. At the start, HCV infection was post-transfusion viral infection, particularly in developing countries. Recently, due to iv drug abuse, HCV infection became number one health problem in well-developed countries as well. Following acute HCV infection, the innateimmune response is triggered in the form of activated coordinated interaction of NK cells, dendritic cells and interferon α. The acquired immune response is then developed in the form of the antibody-mediated immune response(ABIR) and the cell-mediated immune response(CMIR). Both are responsible for clearance of HCV infection in about 15% of infected patients. However, HCV has several mechanisms to evade these antivirus immune reactions. The current review gives an overview of HCV structure, immune response and viral evasion mechanisms. It also evaluates the available preventive and therapeutic vaccines that induce innate, ABIR, CMIR. Moreover, this review highlights the progress in recent HCV vaccination studies either in preclinical or clinical phases. The unsatisfactory identification of HCV infection by the current screening system and the limitations of currently available treatments, including the ineligibility of some chronic HCV patients to such antiviral agents, mandate the development of an effective HCV vaccine. | kouka saadeldin abdelwahab zeinab nabil ahmed said | 2016 | World Journal of Gastroenterology2016，22，2： | 0 |
| 14 | Induced immunity against hepatitis B virus显示文摘Prevention of hepatitis B virus(HBV) infection with its consequent development of HBV chronic liver disease and hepatocellular carcinoma is a global mandatory goal. Fortunately, safe and effective HBV vaccines are currently available. Universal hepatitis B surface antigen HBV vaccination coverage is almost done. Growing knowledge based upon monitoring and surveillance ofHBV vaccination programs has accumulated and the policy of booster vaccination has been evaluated. This review article provides an overview of the natural history of HBV infection, immune responses and the future of HBV infection. It also summarizes the updated sources, types and uses of HBV vaccines, whether in the preclinical phase or in the post-field vaccination. | Zeinab Nabil Ahmed Said Kouka Saadeldin Abdelwahab | 2015 | World Journal of Hepatology2015，7，12： | 0 |
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