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| 1 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 2 | Evolving simple-to-use method to determine watereoil relative permeability in petroleum reservoirs显示文摘In the current research,a new approach constructed based on artificial intelligence concept is introduced to determine water/oil relative permeability at various conditions.To attain an effective tool,various artificial intelligence approaches such as artificial neural network(ANN),hybrid of genetic algorithm and particle swarm optimization(HGAPSO)are examined.Intrinsic potential of feed-forward artificial neural network(ANN)optimized by different optimization algorithms are composed to estimate water/oil relative permeability.The optimization methods such as genetic algorithm,particle swarm optimization and hybrid approach of them are implemented to obtain optimal connection weights involved in the developed smart technique.The constructed intelligent models are evaluated by utilizing extensive experimental data reported in open literature.Results obtained from the proposed intelligent tools were compared with the corresponding experimental relative permeability data.The average absolute deviation between the model predictions and the relevant experimental data was found to be less than 0.1%for hybrid genetic algorithm and particle swarm optimization technique.It is expected that implication of HGAPSO-ANN in relative permeability of water/oil estimation leads to more reliable water/oil relative permeability predictions,resulting in design of more comprehensive simulation and further plans for reservoir production and management. | Mohammad Ali Ahmadi Sohrab Zendehboudi Maurice B.Dusseault Ioannis Chatzis | 2016 | Petroleum2016，2，1： | 2 |
| 3 | Shape-based interpolation of binary 3-D images using morphological skeletonization 显示文摘 | CHATZIS V PITAS I | 1999 | Multimedia Computing and Systems1999，，2： | 2 |
| 4 | An experimental study of secondary oil migration显示文摘 | Catalan L Xiaowen F Chatzis I | 1992 | AAPG Bulletin1992，76，5： | 1 |
| 5 | Work -related and psychological determinants of multisite musculoskeletal pain 显示文摘 | Solidaki E Chatzi L Bitsios P | 2010 | Scand J Work Environ Health2010，36，： | 1 |
| 6 | Fuzzy cell hough transform for curve detection显示文摘 | CHATZIS V PITAS I | | 0，，12： | 1 |
| 7 | A robust fuzzy local information C-means clustering algorithm 显示文摘 | KrinidisS Chatzis V | 2010 | IEEE Transactions on Image Processing2010，19，5： | 1 |
| 8 | An experimental study of secondary oil migration 显示文摘 | Catalan L Xiaowen F Chatzis I | 1992 | AAPG Bulletin1992，76，： | 1 |
| 9 | Permeability and electrical conductivity of porous media from 3D stochastic replicas of the microstructure 显示文摘 | Liang Z Ioannidis M A Chatzis I | 2000 | Chem Eng Sci2000，55，： | 1 |
| 10 | An unsupervised image clustering method based on EEMD image histogram 显示文摘 | Krinidis S Krinidis M Chatzis V | 2012 | Journal of In- formation Hiding and Multimedia Signal Processing2012，3，2： | 1 |
| 11 | A robust fuzzy local information c-means clustering algorithm显示文摘 | KRINIDIS S CHATZIS V | 2010 | IEEE Transactions on Image Processing2010，19，5： | 1 |
| 12 | Assessing skin prick tests reliability in ECRHS-I显示文摘 | Bousquet P J Chatzi L Jarvis D | 2008 | Allergy2008，63，3： | 1 |
| 13 | Indoor and outdoor personal exposure to benzene in Athens,Greece显示文摘 | Chatzis C Alexopoulos EC Linos A | 2005 | Sci Total Environ2005，349，13： | 1 |
| 14 | Statistical analysis of the porous microstructure as a method for estimating reservoir permeability 显示文摘 | Ioannidis M A Kwiecien M J Chatzis I | 1996 | Journal of Petroleum Science and Engineering1996，16，： | 1 |
| 15 | A robust fuzzy local information C-means clustering algorithm 显示文摘 | Krinidis S Chatzis V | 2010 | IEEE Trans on ImageProcessing2010，19，5： | 1 |
| 16 | Relation of microalbuminuria to adiponectin and augmented C-reactive protein levels in men with essential hypertension显示文摘 | Dimitriadis K Chatzis D | 2005 | Am J Cardiol2005，96，： | 1 |
| 17 | Early results after transatrial/transpulmonary repair of tetralogy of Fallot显示文摘 | Giannopoulos N M Chatzis AK Karros P | 2002 | Eur J Cardiothorac Surg2002，22，4： | 1 |
| 18 | Fuzzy energy-based active contours显示文摘 | KRINIDIS S CHATZIS V | 2009 | IEEE Transactions on Image Processing2009，18，12： | 1 |
| 19 | A fuzzy clustering approach toward hidden Markov random field models for enhanced spatially constrained image segmentation 显示文摘 | Chatzis S P Varvarigou T A | 2008 | IEEE Transactions on Fuzzy Systems2008，16，5： | 1 |
| 20 | Primary retroperitoneal mucinous cysta- denoma显示文摘 | PAPADOPOULOU D CHATZI RALLI I FILITAT- ZI CH | 2011 | Hippokratia2011，15，2： | 1 |
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