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| 1 | Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase显示文摘Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and motility.The MAPK pathways can be divided into conventional and atypical MAPK pathways.The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and MAPK.Atypical MAPK pathways are not organized into this three-tiered cascade.MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases.The latter are referred to as MAPK-activated protein kinases.This review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways.Recent findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed. | Sergiy Kostenko Gianina Dumitriu Kari Jenssen Lgreid Ugo Moens | 2011 | World Journal of Biological Chemistry2011，2，5： | 8 |
| 2 | Crystal structure ofHLA - G: A nonclassical MHC class 1 molecule expressed at the fetalmatemalinterface显示文摘 | Clements CS Kjer - Nielsen L Kostenko L | 2005 | Proc Natl Acad Sci US A2005，102，9： | 1 |
| 3 | Partitioning of Bromine between Brine and Halite显示文摘 | Kostenko I F | 1974 | Geochemistry International1974，，： | 1 |
| 4 | Structural evaluation of column-height controls at a toe-thrust discovery, deep-water Niger Delta显示文摘 | Kostenko O V Naruk S J Hack W et 81 | 2008 | AAPG Bulletin2008，92，12： | 1 |
| 5 | Relations between the mi- togen-activated protein kinase and the cAMP-dependent protein kinase pathways : comradeship and hostility显示文摘 | Gerits N Kostenko S Shiryaev A | 2008 | Cell Signal2008，20，9： | 1 |
| 6 | Fast and accurate computation of spherical harmonic coefficients from satellite gravity gradiometry data显示文摘 | Ditmar P Klees R and Kostenko F | 2003 | Journal of Geodesy2003，76，： | 1 |
| 7 | Structural evaluation of column-height controls at a toe-thru:,;t discovery, deep-water Niger Delta显示文摘 | Olga V Kostenko Steve J Naruk Willem Hack | 2008 | AAPG Bulletin2008，92，12： | 1 |
| 8 | Preparation, structure and thermal stability of onium-and amino-functionalized silicas for the use as catalysts supports显示文摘 | Kovalchuk T Sfihi H Kostenko L | 2006 | Journal of Colloid and In terface Science2006，302，1： | 1 |
| 9 | Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer com- plexed to the therapeutic mAb OKT3 显示文摘 | Kjer-Nielsen L Dunstone M A Kostenko L | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 10 | Crystal structure of HLA-G:a nonclassical MHC class I morecule expressed at the fetalmaternal interface显示文摘 | Clements CS Kjer-Nielsen L Kostenko L | 2005 | Proc Natl Acad Sci2005，102，9： | 1 |
| 11 | Heat shock protein 27 phosphory-lation:kinases,phosphatases,functions and pathology显示文摘 | Kostenko S Moens U | | 0，，20： | 1 |
| 12 | Crystal structure of HLA-G:a nonclassical MHC class-Ⅰ molecule expressed at the fetal-maternal interface显示文摘 | Clements CS Kjer-Nielsen L Kostenko L | 2005 | Proc Natal Acad Sci2005，102，9： | 1 |
| 13 | Crystal structure of HLA-G:a nonclassical MHC class I molecule expressed at the fetal-maternal interface显示文摘 | Clements CS Kjer-Nielsen L Kostenko L | 2005 | Proc Natl Acad Sci U S A2005，102，9： | 1 |
| 14 | Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology显示文摘 | Sergiy Kostenko Ugo Moens | 2009 | Cellular and Molecular Life Sciences2009，，20： | 1 |
| 15 | Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins显示文摘 | Jenko KL Zhang Y Kostenko Y | 2014 | Analyst2014，139，20： | 1 |
| 16 | Kinetics aggregation of magnetic suspensions显示文摘 | Bossis G Iskakova L Kostenko V | 2011 | Physica A:Statistical Mechanics and its Applications2011，390，14： | 1 |
| 17 | Crystal structure of HLA-G a nonclassical MHC class 1 molecule expressed at the fetal- malemal interface 显示文摘 | Clements CS Kjer-Nielsen L Kostenko L el al | 2005 | Proc Natl Acad Sci2005，102，9： | 1 |
| 18 | The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt显示文摘 | Clements CS Kjer-Nielsen L Kostenko L | 2006 | Acta Crystallogr Sect F Struct Biol Cryst Commun2006，62，1： | 1 |
| 19 | Heat shock protein 27 phosphorylation:Kinases,phosphat-ases,functions and pathology显示文摘 | Kostenko S Moens U | 2009 | Cell Mol Life Sci2009，，66： | 1 |
| 20 | The diterpenoid alka-loid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor显示文摘 | Kostenko S Khan MT Syhe I | 2011 | Cell Mol Life Sci2011，68，2： | 1 |
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