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| 1 | Scoring evaluation of the natural course of mucopolysaccharidosis type IIIA (Sanfilippo syndrome type A)显示文摘 | Meyer A Kossow K Gal A | 2007 | Pediatrics2007，120，5： | 1 |
| 2 | Headache as the sole presentation of acute myocardial infarction in two elderly patients 显示文摘 | Amendo MT Brown BA Kossow LB | 2001 | Am J Geriatr Cardiol2001，10，2： | 1 |
| 3 | Systems biology of JAK-STAT signalling in human malignancies显示文摘 | Julio Vera Katja Rateitschak Falko Lange Christina Kossow Olaf Wolkenhauer Robert Jaster | 2011 | Progress in Biophysics and Molecular Biology2011，，2： | 1 |
| 4 | Reliability of linear consecutively-connected systems with multistate components显示文摘 | Kossow A Preuss W | 1995 | IEEE Transactions on Reliability1995，44，3： | 1 |
| 5 | Duplication of bladder and urethra, and associated anomalies显示文摘 | Kossow JH Morales PA | 1973 | Urology1973，1，： | 1 |
| 6 | Preoperativerisk analysis~a reliable predictor of postoperative outcome af-ter transthoracic esophagectomy? 显示文摘 | Schroder W Bollschweiler E Kossow C | 2006 | Langenbecks ArchSurg2006，391，5： | 1 |
| 7 | Antlviral treatment and prophylaxis of influenza in primary care: German recommendations 显示文摘 | Wutzler P Kossow KD Lode H | 2004 | J Clin Virol2004，31，： | 1 |
| 8 | Scoliosis and chest cage deformity measures predicting impairments in pul- monary function: a cross-sectional study of 492 patients with scoliosis to improve the early identification of patients at risk显示文摘 | Dreimann M Hoffmann M Kossow K | 2014 | Spine (Phila Pa 1976)2014，39，24： | 1 |
| 9 | A generalization of consecutive-k-out-of-n: F system 显示文摘 | Boehme T K Kossow A Preuss W | 1992 | IEEE Transactions on Reliability1992，41，： | 1 |
| 10 | Headache as the sole presentation of acute myocardial infarction in two elderly patients 显示文摘 | Amendo MT Brown BA Kossow LB | 2001 | Am J Gefiatr Cardio2001，10，2： | 1 |
| 11 | Scoliosis and chest cage deformity measures predicting impairments in pulmonary function : a cross- sectional study of 492 patients with scoliosis to improve the early identification of patients at risk 显示文摘 | Dreimann M Hoffmann M Kossow K | 2014 | Spine ( Phila Pa 1976 )2014，39，24： | 1 |
| 12 | Structure and quantification of processes controlling the evolution of the inverted NE-German basin显示文摘 | Kossow D Krawczyk C M | 2002 | Marine and Petroleum Geology2002，19，5： | 1 |
| 13 | Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach显示文摘AIM:To gain insights into the molecular action of erlotinib in pancreatic cancer (PC) cells. METHODS:Two PC cell lines, BxPC-3 and Capan-1, were treated with various concentrations of erlotinib, the specific mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and protein kinase B (AKT) inhibitor XIV. DNA synthesis was measured by 5-bromo-2'-deoxyuridine (BrdU) assays. Expression and phosphorylation of the epidermal growth factor receptor (EGFR) and downstream signaling molecules were quantified by Western blot analysis. The data were processed to calibrate a mathematical model, based on ordinary differential equations, describing the EGFRmediated signal transduction. RESULTS:Erlotinib significantly inhibited BrdU incorporation in BxPC-3 cells at a concentration of 1 mol/L, whereas Capan-1 cells were much more resistant. In both cell lines, MEK inhibitor U0126 and erlotinib attenuated DNA synthesis in a cumulative manner, whereas the AKT pathway-specific inhibitor did not enhance the effects of erlotinib. While basal phosphorylation of EGFR and extracellular signal-regulated kinase (ERK) did not differ much between the two cell lines, BxPC-3 cells displayed a more than five-times higher basal phospho-AKT level than Capan-1 cells. Epidermal growth factor (EGF) at 10 ng/mL induced the phosphorylation of EGFR, AKT and ERK in both cell lines with similar kinetics. In BxPC-3 cells, higher levels of phospho-AKT and phospho-ERK (normalized to the total protein levels) were observed. Independent of the cell line, erlotinib efficiently inhibited phosphorylation of EGFR, AKT and ERK. The mathematical model successfully simulated the experimental findings and provided predictions regarding phosphoprotein levels that could be verified experimentally. CONCLUSION:Our data suggest basal AKT phosphorylation and the degree of EGF-induced activation of AKT and ERK as molecular determinants of erlotinib efficiency in PC cells. | Falko Lange Katja Rateitschak Christina Kossow Olaf Wolkenhauer Robert Jaster | 2012 | World Journal of Gastroenterology2012，18，43： | 1 |
| 14 | Headache as the sole presentation of acute myocardial infarction in two elderly patients显示文摘 | Amendo MT Brown BA Kossow LB | 2001 | Am J Geriatr Cardi- ol2001，10，2： | 1 |
| 15 | Duplication of bladder and urethra, and associated anomalies显示文摘 | Kossow J H Morales P A | 1973 | Urology1973，1，： | 1 |
| 16 | Webquest: Tools for Differ- entiation显示文摘 | Heidi Schweizer Ben Kossow | 2007 | Gifted Child Today2007，30，1： | 1 |
| 17 | Preoperative risk analysis—a reliable predictor of postoperative outcome after transthoracic esophagectomy?显示文摘 | W. Schr?der E. Bollschweiler C. Kossow A. H. H?lscher | 2006 | Langenbeck’s Archives of Surgery2006，，5： | 1 |
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