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| 1 | Apoptosis and DNA damage in human spermatozoa显示文摘DNA 损坏经常在 subfertile 男性的精子被遇到并且包括损害授精与不利临床的结果的一个范围被相关,破坏 preimplantation 胚胎的开发,流产的增加的率和在子孙的疾病的提高的风险。在人的精子的 DNA 破碎的病原学密切与氧化的底的外观被相关使内收并且损害精子形式的证据。我们假设那个氧化压力阻碍精子形式,与糟糕改变的染色质导致精子的产生。这些有缺点的房间有一个趋势默认到线粒体与活动性损失, caspase 激活, phosphatidylserine exteriorization 和免费激进的产生的激活联系的一条 apoptotic 小径。后者导致类脂化合物 peroxidation 和氧化 DNA 损坏,它然后导致 DNA 破碎和房间死亡。精子的物理体系结构阻止从获得存取到原子 DNA 并且导致它的破碎由于这 apoptotic 进程激活的任何核酸酶。是为这个原因在人的精子遇到的 DNA 损坏的一个多数似乎氧化。给氧化应力似乎在 DNA 损坏的病原学有的重要角色,应该为在这个条件的处理的抗氧化剂有一个重要角色。如果在精子的氧化 DNA 损坏正在提供全身的氧化应力的敏感读出,这些调查结果的含意能在我们试着作为一篇序言在精子最小化 DNA 损坏到帮助概念治疗的立即的目标以外拉长。 | R John Aitken Adam J Koppers | 2011 | Asian Journal of Andrology2011，13，1： | 46 |
| 2 | Proteomic changes in mammalian spermatozoa during epididymal maturation显示文摘附睾成熟与 cAMP-inducedtyrosine 磷酸化串联的激活被联系,它最终与表达式被联系 ofcapacitation 依赖的精子工作,例如亢奋的激活的运动和 acrosomal exocytosis。通过附睾的 Asspermatozoa 进步他们首先在主要的片上在目标上获得能力到 phosphorylatetyrosine,由中间的片列在后面。等到这些房间 haver eached 附睾尾他们装 phosphorylate 从颈的全部尾巴到结束片。磷酸化的 Thisparticular 模式与能够使肥沃的充分功能的精子的个体发生被联系卵母细胞。这改变的 Proteomic 分析 indicate 与几 mitochondrial 蛋白质的磷酸化被联系, amitochondrial 膜电位的创造和 mitochondrial 自由基产生的激活。至少在啮齿类动物种类,精子线粒体的激活看起来是特别地重要的部分 ofepididymal 成熟。 | R. John Aitken Brett Nixon Minjie Lin Adam J. Koppers Yun H. Lee Mark A. Baker | 2007 | Asian Journal of Andrology2007，9，4： | 14 |
| 3 | The role of cysteine-rich secretory proteins in male fertility显示文摘充满半胱氨酸的能分泌的蛋白质(CRISPs ) 是 CRISP,的亚群抗原 5 并且 Pr-1 (帽子) 蛋白质总科,并且仅仅在脊椎动物被发现。他们显示出强壮的表示偏爱到哺乳动物的男繁殖的道和有毒的爬行动物的毒液。在男繁殖的道以内, CRISPs 在跨越 haploid 细菌房间开发, epididymal 成熟, capacitation,活动性和授精的实际进程的男细菌房间生物学的许多方面被含有。在结构的水平, CRISPs 由二个领域,一个帽子领域,它在房间鈥揷e ll 粘附被含有,和一个松脆的领域组成,它被显示了越过多重种类调整离子隧道的几个班。此处,我们将在男富饶在 CRISPs 的角色上考察当前的文学,并且由到相关非哺乳动物的蛋白质的推理,推断潜在的生物化学的功能。 | Adam J Koppers Thulasimala Reddy Moira K O'Bryan | 2011 | Asian Journal of Andrology2011，13，1： | 8 |
| 4 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 5 | Evidence for a novel gene associated with low tumor metastatic potiential显示文摘 | Steeg PS Bevilacque G Kopper L etal | 1988 | J Natl Cancer Inset1988，80，3： | 1 |
| 6 | Evidence for a novel gene associated with low tumor metastatic potential显示文摘 | Steeg PS Bevilacqua G Kopper L | 1988 | J Natl Cancer Inst1988，80，： | 1 |
| 7 | ArArCALC - Software for ^40Ar/^39Ar age calculations显示文摘 | Koppers A A P | 2002 | Comput Geosci2002，28，5： | 1 |
| 8 | Perioperative intra- venous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery显示文摘 | Kopper W Weigand M Neumann F | 2004 | Anesth Analg2004，98，： | 1 |
| 9 | Tissue-and age-dependent differences in the complexation of cadmium and zinc in the cadmium/zinc hyperaceumulator Thlaspi caerulescens (Ganges ecotype)revealed by X-ray absorption spectroscopy显示文摘 | KOPPER H MIJOVILOVICH A MEYER-KLAUCKE W | 2004 | Plant Physiology2004，134，2： | 1 |
| 10 | Model for integrated process and microstructure simulation in hot forming 显示文摘 | Kopper R | 1992 | Steel Research1992，63，6： | 1 |
| 11 | Software for ^40Ar-^39Ar age calculations显示文摘 | Koppers A A P | 2002 | Comput Geosci2002，28，60： | 1 |
| 12 | Evidence for a novel gene associated with cow humor metastatic potential显示文摘 | Steeg P S Bevilacqua G Kopper L | 1988 | J Natl Cancer Inst1988，80，3： | 1 |
| 13 | Evidence for a noval gene associated with low tumor metastasis potential显示文摘 | Steeg PS Bevilacqua G Kopper L | 1988 | J Nat Cancer Inst1988，80，： | 1 |
| 14 | Genomics of lung cancer may change diagnosis, prognosis and therapy 显示文摘 | Kopper L Timar J | 2005 | Pathol Oncol Res2005，11，1： | 1 |
| 15 | ArArCALC-software for ^Ar/^Ar age calcula-tions 显示文摘 | Koppers A A | 2002 | Computers and Geosciences2002，28，5： | 1 |
| 16 | Low-dose lidocaine re- duces secondary hyperlgsia by a central mode of action显示文摘 | Kopper W Ostermeier N Sittl R | 2000 | Pain2000，85，： | 1 |
| 17 | Morphologic changes of extrahepaic bile duct during obstruction and subsequent decompression by endoprosthesis 显示文摘 | Karsten T M Bossnn A Kopper P J | 1992 | Surgery1992，111，8： | 1 |
| 18 | Evidence for a novel gene associated with low tumor relation potential显示文摘 | Steeg PS Bevilacgua G Kopper L | 1988 | J Natl Cancer Inst1988，80，3： | 1 |
| 19 | Model for integrated process and microstucture simulaion in hot forming显示文摘 | Karhausen K Kopper R | 1992 | Steel Reasearch1992，63，6： | 1 |
| 20 | Evidence for a novel gene associated with low tumor metastatic potential显示文摘 | Steeg PS Bevilacqua G Kopper L etal | 1988 | J NatlCancer Inst1988，80，3： | 1 |
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