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| 1 | Apoptosis and DNA damage in human spermatozoa显示文摘DNA 损坏经常在 subfertile 男性的精子被遇到并且包括损害授精与不利临床的结果的一个范围被相关,破坏 preimplantation 胚胎的开发,流产的增加的率和在子孙的疾病的提高的风险。在人的精子的 DNA 破碎的病原学密切与氧化的底的外观被相关使内收并且损害精子形式的证据。我们假设那个氧化压力阻碍精子形式,与糟糕改变的染色质导致精子的产生。这些有缺点的房间有一个趋势默认到线粒体与活动性损失, caspase 激活, phosphatidylserine exteriorization 和免费激进的产生的激活联系的一条 apoptotic 小径。后者导致类脂化合物 peroxidation 和氧化 DNA 损坏,它然后导致 DNA 破碎和房间死亡。精子的物理体系结构阻止从获得存取到原子 DNA 并且导致它的破碎由于这 apoptotic 进程激活的任何核酸酶。是为这个原因在人的精子遇到的 DNA 损坏的一个多数似乎氧化。给氧化应力似乎在 DNA 损坏的病原学有的重要角色,应该为在这个条件的处理的抗氧化剂有一个重要角色。如果在精子的氧化 DNA 损坏正在提供全身的氧化应力的敏感读出,这些调查结果的含意能在我们试着作为一篇序言在精子最小化 DNA 损坏到帮助概念治疗的立即的目标以外拉长。 | R John Aitken Adam J Koppers | 2011 | Asian Journal of Andrology2011，13，1： | 46 |
| 2 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 3 | Model for integrated process and microstructure simulation in hot forming 显示文摘 | Kopper R | 1992 | Steel Research1992，63，6： | 1 |
| 4 | Low-dose lidocaine re- duces secondary hyperlgsia by a central mode of action显示文摘 | Kopper W Ostermeier N Sittl R | 2000 | Pain2000，85，： | 1 |
| 5 | Model for integrated process and microstucture simulaion in hot forming显示文摘 | Karhausen K Kopper R | 1992 | Steel Reasearch1992，63，6： | 1 |
| 6 | Experimental Investigation of endwall profiling in a turbine vane cascade 显示文摘 | Kopper F C Milano R Vanco M | 1981 | AIAA Journal1981，19，8： | 1 |
| 7 | High-resolution 40Ar/39 Ar dating of the oldest oceanic basement basalts in the western Pacific Basin显示文摘 | Koppers A A P Staudigel H Duncan R A | 2003 | Geochemistry Geophysics Geosystems2003，4，11： | 1 |
| 8 | Exercise performance improves in patients with COPD due to respiratory muscle endurance training显示文摘 | Koppers R Vos P Boot C | 2006 | Chest2006，129，4： | 1 |
| 9 | Experimental Investigation of Endwall Pro- filing in a Turbine Vane Cascade 显示文摘 | Kopper F C Milano R | 1981 | AIAA Journal1981，19，8： | 1 |
| 10 | The Magellan seamounts trail:implications for Cretaceous hotspot volcanism and absolute Pacific plate motion显示文摘 | KOPPERS A A P STAUDIGEL H WIJBRANS J R | 1998 | Earth and Planetary Science Letters1998，163，： | 1 |
| 11 | Protein struc-ture play a critical role in peanut allergen stability and may determine immunodominant IgE-bingdi-ng epitopes显示文摘 | Sen M Kopper R Pons L | 2002 | J Immunol2002，169，2： | 1 |
| 12 | Estimation of time delay by coherence analysis显示文摘 | Govindan R B Raethjen J Kopper F | 2005 | Physica A: Statistical Mechanics and its Applications2005，350，24： | 1 |
| 13 | Structure of the major peanut allergen Ara hl may protect IgE-binding epitopes from degradation 显示文摘 | Maleki S J Kopper R A Shin D S | 2000 | The Journal of Immunology2000，164，11： | 1 |
| 14 | Adsorption of peanut (Araehis hypogaea, Leguminosae) proteins by activated charcoal显示文摘 | KOPPER R A KIM A VAN T | 2008 | J Agric Food Chem2008，56，10： | 1 |
| 15 | The Magellan seamount trail: implications for Cretaceous hotspot volcan ism and absolute Pacific plate motion显示文摘 | KOPPERS A A P STAUDIGEL H WIJBRANS J R | 1998 | Earth and Planetary Science Letters1998，163，： | 1 |
| 16 | Model for integrated process and microstructure simulation in hot forming 显示文摘 | Karhausen K Kopper R | 1992 | Steel Reasearch1992，63，6： | 1 |
| 17 | Exercise performance improves in patients with COPD due to respiratory muscle endurance training 显示文摘 | Koppers R J Vos PJ Boot CR | 2006 | Chest2006，129，： | 1 |
| 18 | The reasons for living in- ventory for adolescents (RFL- A) Development and psychometric properties显示文摘 | Osman A Downs W R Kopper B A | 1998 | Journal of Clinical Psychology1998，54，： | 1 |
| 19 | Argon Geochronology of Small Samples Using the Vulkaan Argon Laserprobe 显示文摘 | Wijbrans J R Pringle M S Koppers A A P | 1995 | Proc Koninklijke Academic Wetenschappen1995，98，2： | 1 |
| 20 | Model for integrated process and microstructure simulation in hot forming 显示文摘 | Karhausen K Kopper R | 1992 | Steel Reasearch1992，63，6： | 1 |
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