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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Critical challenges for picoTesla magnetic-tunnel-junction sensors 显示文摘 | Egelhoff Jr W F Pong P W T Unguris J | 2009 | J Sensors and Actualtors A2009，，： | 1 |
| 4 | Step - up therapy for children with uncontrolled asthma receiving in- haled corticosteroids显示文摘 | Lemanske Jr R F Manger D T Sorkness C A | 2010 | New England Journal of Medicine2010，362，11： | 1 |
| 5 | The Use of Fractal Techniques for Flow Regime Identification显示文摘 | Franca F Acikgoz M Jr Lahey R T | 1991 | Int J Multiphase Flow1991，17，4： | 1 |
| 6 | An experimental study on air carry-un- der due to a plunging liquid jet 显示文摘 | Bonetto F Lahcy Jr R T | 1993 | International Journal of Mul- tiphase Flow1993，19，： | 1 |
| 7 | Mathematical modeling of mean flow stress during the hot strip rolling of Nb steels显示文摘 | Minami K Siciliano F Jr Maccagno T M | 1996 | ISIJ International1996，36，12： | 1 |
| 8 | Engineered communication for microbial robotics显示文摘 | Weis R Jr T F Knight | 2000 | DNA62000，6，： | 1 |
| 9 | Dynamic model- ing of a dual clearance squeeze film damper:Part I test rigand dynamic model with one damper显示文摘 | Moraru L Keith T G Jr Dimofte F | 2003 | Tribology Trans- actions2003，46，2： | 1 |
| 10 | Advances in GML for geospatial applications显示文摘 | Lu C T Dos Santos Jr R F Sripada L N | 2007 | Journal of Computer Applications Geoinformatica2007，11，： | 1 |
| 11 | Cardiovascular complications of obesity in adolescents显示文摘 | Orio F Jr Palomba S Cascella T | 2007 | J Endocrinol Invest2007，30，1： | 1 |
| 12 | Numerical method for convection-dominated diffusion problem based on combining the method of characteistics with finite element of finite difference procedures显示文摘 | DOUGLAS L JR RUSSELL T F | 1982 | SIAM J Numer Anal1982，19，5： | 1 |
| 13 | Evaluating damage potential in buildings affected by excavations 显示文摘 | Finno R J Voss Jr F T Rossow E | 2005 | Journal of Geotechnical and Geoenvironmental Engi- neering2005，131，10： | 1 |
| 14 | Responsive cortical stimulation for the treatment of epilepsy 显示文摘 | Sun F T Morrell M J Wharen R E Jr | 2008 | Neurotherapeutics2008，5，1： | 1 |
| 15 | Supplemental energy dissipation: State-of-the-art and state-of-the-practice显示文摘 | SOONG T T SPENCER JR B F | 2002 | Engineering Structures2002，24，： | 1 |
| 16 | Alkylation of aromatics with ethylene and propylene: Recent developments in commercial processes显示文摘 | DEGNAN T F Jr SMITH M C VENKAT C R | 2001 | Appl Catal A2001，221，12： | 1 |
| 17 | Hole doping of the CuO2 chains(La,Sr,Ca)14Cu24 O41显示文摘 | CARTER S A BATLOGG B CAVA R J KRAJEWSKI J J PECK JR W F RICE T M | 1996 | Phys Rev Lett1996，77，7： | 1 |
| 18 | Dynamic model- ing of a dual clearance squeeze film damper: Part II 显示文摘 | Moraru L Keith T G Jr Dimofte F | 2006 | Tribology Transactions2006，49，4： | 1 |
| 19 | Uterine effects of clomiphene citrate in women with polycystic ovary syndrome:a prospective controlled study显示文摘 | Palomba S Russo T Orio F Jr | | 0，，11： | 1 |
| 20 | Antiproliferative and proapop- totic effects of raloxifene on uterine leiomyomas in postmeno pausal women显示文摘 | Palomba S Orio F Jr Russo T | 2005 | Fertil Steril2005，84，1： | 1 |
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