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| 1 | Pancreatic necrosis:Complications and changing trend of treatment显示文摘Incidence of acute pancreatitis seems to be increasing in the Western countries and has been associated with significantly increased morbidity. Nearly 80% of the patients with acute pancreatitis undergo resolution; some develop complications including pancreatic necrosis. Infection of pancreatic necrosis is the leading cause of death in these patients. A significant portion of these patients needs surgical interventions. Traditionally, the 'gold standard' procedure has been the open surgical necrosectomy, which is now being completed by the relatively lesser invasive interventions. Minimally invasive surgical(MIS) procedures include endoscopic drainage, percutaneous image-guided catheter drainage, and retroperitoneal drainage. This review article discusses the open and MIS interventions for pancreatic necrosis with each having its own respective benefits and disadvantages are covered. | Mamoon Ur Rashid Ishtiaq Hussain Sundas Jehanzeb Waqas Ullah Saeed Ali Akriti Gupta Jain Neelam Khetpal Sarfraz Ahmad | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 7 |
| 2 | Concurrent removal of intravitreal lens fragments after phacoemulsification with pars plana vitrectomy prevents development of retinal detachment显示文摘AIM: To evaluate the outcomes of 'concurrent vitrectomy' to retrieve dislocated lens fragment during phacoemulsification.METHODS: In a retrospective, observational case series, data of patients who underwent 'concurrent' pars plana vitrectomy(PPV) for dislocated lens fragments between the period 2000 and 2008 were reviewed. Data collected included patient demographics, pre-operative visual acuity, intra-operative occurrence of retinal breaks, duration of follow up, post-operative intraocular pressure, final best-corrected visual acuity(BCVA),presence of cystoid macular edema(CME) and occurrence of rhegmatogenous retinal detachment(RRD).· RESULTS: A total of 58 eyes of 58 patients were included in the study. At 12 mo the mean postoperative BCVA was log MAR 0.17(20/30) with a range of log MAR0 to 0.69(20/20 to 20/100), with 96.6%(56/58) of patients showing post- operative improvement in visual acuity(P =0.005). None of the patients developed postoperative retinal detachment, endophthalmitis or non-resolving uveitis at 12 mo.CONCLUSION: Our study results suggest concurrent PPV for retained lens fragments after cataract surgery is beneficial and may decrease the risk of glaucoma and prevent development of RRD. | Kakarla V Chalam Ravi K Murthy Joshua C Priluck Vijay Khetpal Shailesh K Gupta | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 3 | Colon mucosal neoplasia referred for endoscopic mucosal resection:Recurrence of adenomas and prediction of submucosal invasion显示文摘BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic evaluation.This is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United States.AIM To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal neoplasia.METHODS This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February 2017.The main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 mo.RESULTS A total of 480 patients with 500 lesions were included in the study.The median age was 68(Inter quantile range:14)with 52%males.The most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most prevalent.Submucosal invasion was present in 23(4.6%)out of 500 lesions.The independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value<0.004)and Paris classification 0-IIc(Odds ratio:18.2;P value<0.01).Out of 500,354 post-endoscopic mucosal resection scars were examined at surveillance colonoscopy.Recurrence was noted in 21.8%(77 cases).CONCLUSION There was overall low prevalence of SMIL in our study.Kudo pit pattern(IIIL+IV and V)and Paris classification 0-IIc were the only factors identified as an independent risk factor for submucosal invasion.The independent risk factor for recurrence was adenoma size(>40 mm).Almost all recurrences(98.8%)were treated endoscopically. | Mamoon Ur Rashid Neelam Khetpal Hammad Zafar Saeed Ali Evgeny Idrisov Yuan Du Assaf Stein Deepanshu Jain Muhammad Khalid Hasan | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，7： | 3 |
| 4 | Spirituality, social support, and survival in hemodialysis patients显示文摘 | Spinale J Cohen S D Khetpal P | 2008 | Clin J Am Soc Nephrol2008，3，6： | 1 |
| 5 | Cortical visual impairment:etiology,associated findings,and prognosis in a tertiary care setting显示文摘 | Khetpal V Donahue SP | 2007 | J AAPOS2007，11，3： | 1 |
| 6 | Retained metallic foreign bodies after phacoemulsification 显示文摘 | Ahmed Y Khetpal V Fay | 2011 | Clin Experiment Ophthalmol2011，39，7： | 1 |
| 7 | Platelet function beyond hemostasis and thrombosis显示文摘 | Ware J Corken A Khetpal R | 2013 | Current Opinion in Hematology2013，20，5： | 1 |
| 8 | Cortical visual impairment:etiology,associated findings,and prognosis in a tertiary care setting显示文摘 | Khetpal V Donahue SP | 2007 | J AAPOS2007，11，3： | 1 |
| 9 | Spectral domain optical coherence tomography documented rapid resolution of pseudophakic cystoid macular edema with topical difluprednate 显示文摘 | Chalam K Khetpal V Patel CJ | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 10 | Platelet function beyond hemostasis and thrombosis显示文摘 | Ware J Corken A Khetpal R | 2013 | Curr Opin Hematol2013，20，5： | 1 |
| 11 | A Review: Role of Ultraviolet Radiation in Age-Related Macular Degeneration显示文摘 | K V Chalam Vijay Khetpal Raluca Rusovici Sankarathi Balaiya | 2011 | Eye & Contact Lens: Science & Clinical Practice2011，，4： | 1 |
| 12 | Hypoxia initiates sirtuinl -mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor -2α显示文摘 | Balaiya S Khetpal V Chalam KV | 2012 | Mol Vis2012，18，： | 1 |
| 13 | New miniaturized contact lens for wide-angle fundus fluorescein angiography:wide- angle fluorescein angiography lens 显示文摘 | Chalam KV Mclauchlan T Khetpal V | 2012 | Retina2012，32，3： | 1 |
| 14 | Cytokine patterns and survival in haemodialysis patients 显示文摘 | Cohen SD Phillips TM Khetpal P | 2010 | Nephrol Dial Transplant2010，25，4： | 1 |
| 15 | Pain, sleep dis- turbance, and quality of life in patients with chronic kid- ney disease显示文摘 | Cohen SD Patel SS Khetpal P | 2007 | Clin J Am Soc Nephrol2007，2，5： | 1 |
| 16 | Hypoxia initiates sirtuinlmediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2alpha显示文摘 | Balaiya S Khetpal V Chalam KV | | 0，，： | 1 |
| 17 | Pain, sleep disturb- ance and survival in hemodialysis patients 显示文摘 | Harris TJ Nazir R Khetpal P | 2012 | Nephrol Dial Transplant2012，27，2： | 1 |
| 18 | Hypoxia initiates sirtuin1‐mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α显示文摘 | BALAIYA S KHETPAL V CHALAM KV | 2012 | Mol Vis2012，，18： | 1 |
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