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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Management of dyslipidemias with fibrates,alone and in combination with statins:role of delayed-release fenofibric acid显示文摘 | Moutzouri E Kei A Elisaf MS | 2010 | Vasc Health Risk Manag2010，6，： | 1 |
| 3 | Purpose- Built Anisotropic Metal Oxide Material:? 3D Highly Oriented Microrod Array of ZnO 显示文摘 | VAYSSIERES L KEIS K LINDQUIST S - E | 2001 | The Jour- nal of Physical Chemistry B2001，105，17： | 1 |
| 4 | A 5% efficient photoelectrochemical solar cell based on nanostructured ZnO electrodes 显示文摘 | Keis K Magnusson E Lindstrom H | 2002 | Sol Energy Ma- ter Sol Cells2002，73，1： | 1 |
| 5 | 显示文摘 | Keis K Magnusson E Lindstrom H | 2002 | Solar Energy Materials and Solar Cells2002，73，： | 1 |
| 6 | On the distribution of the duration of Negative surplus显示文摘 | Dos Keis A D E | 1996 | Scand Actuarial J1996，2，： | 1 |
| 7 | Household catastro- phic health expenditure: a multicountry analysis显示文摘 | Ke Xu David B E Kei Kawabata | 2003 | Lancet2003，，362： | 1 |
| 8 | Purpose-built anisotropic metal oxide material : 3D Highly oriented microrod array of ZnO显示文摘 | VAYSSIERES L KEIS K LINDUIST S E | 2001 | Phys Chem B2001，105，： | 1 |
| 9 | Effect of hypolipidemic treatment on glyeemic profile in patients with mixed dys- lipidemia显示文摘 | Kei A Liberopoulos E Elisaf M | 2014 | Atherosclerosis2014，235，2： | 1 |
| 10 | Purposebuilt anisotropic metal oxide material: 3D highly oriented microrod array of ZnO显示文摘 | Keis K Lindquist S E | 2001 | J Phys Chem B2001，105，： | 1 |
| 11 | 显示文摘 | Keis K Magnusson E Lindstrom H | 2002 | Sol Energy2002，7351，： | 1 |
| 12 | Modification of the leukapheresis procedure for use in rhesus monkeys ( Macaca mulatta) 显示文摘 | Naohide A Masaaki K Kei E | 2003 | J Clin Apheresis2003，18，： | 1 |
| 13 | Purpose-built anistropic metal oxide material: 3D highly oriented microrod array ofZnO 显示文摘 | VAYSSIERES L KEIS K LINDQUIST E E HAGFELDT A | 2001 | J Phys Chem B2001，105，： | 1 |
| 14 | Nanostructured ZnO electrodes for photovohaic applications 显示文摘 | KEIS K VAYSSIERES L INDQUIST S E | 1999 | Nanostructured Mater1999，12，： | 1 |
| 15 | Household catastrophic health expenditure: a multi-country analysis 显示文摘 | Ke Xu David B E Kei Kawabata | 2003 | Lancet2003，，362： | 1 |
| 16 | Nanostructured ZnO Electrodes for Photovoltaic Applications显示文摘 | Keis K Vayssieres L Lindquist S E | 1999 | Nanostructured Materials1999，12，14： | 1 |
| 17 | Purpose-built anisotropic metal oxide material:3D highly oriented microrodarray of Zn0显示文摘 | Vayssieres L Keis K Lindquist S E Hagfeldt A | | 0，，17： | 1 |
| 18 | Preoperative luteininzing hormone levels predict the ovulatory response to laparoscopic ovarian drilling in patients with domlphene citrate- resistant polycystlc ovary syndrome显示文摘 | Hiroshi H Kei E Hisae E | 2005 | Gynecol Endocrinol2005，21，6： | 1 |
| 19 | On transitive cayley graphs of groups and semigrorups 显示文摘 | KEI AREV A V PRAEGER C E | 2003 | European Journal of Combinatorics2003，24，： | 1 |
| 20 | High light-to-energy conversion efficiencies for solar cells based on nanostructured ZnO electrodes 显示文摘 | RENSMO H KEIS K L1NDSTROM H SODERGREN S SOLBRAND A HAGFELDT A LINDQUIST S E WANG L N MUHAMMED M | 1997 | Journal of Physics Chemistry1997，101，14： | 1 |
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