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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells显示文摘 | Heakal Y Kester M | 2009 | Mol Cancer Res2009，7，5： | 1 |
| 3 | Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters显示文摘 | Kester M H Bulduk S Van Toor H | 2002 | The Journal of Clinical Endocrinology and Metabolism2002，87，3： | 1 |
| 4 | Shock absorption charac teristics of running shoes显示文摘 | COOK S KESTER M BRUNET M | 1985 | Am J Sports Med1985，13，： | 1 |
| 5 | Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in human tracheal epithelial cells in vitro显示文摘 | Walenga RW Kester M Coroneos E | 1996 | Prostaglandins1996，52，5： | 1 |
| 6 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 7 | Use of suspended leg technique for minimally invasive total knee arthmplasty显示文摘 | Bonutti P Kester M | 2003 | Orthopedics2003，26，： | 1 |
| 8 | The history of DES,lessons to be learned显示文摘 | Kester M Berg LT | 2005 | Pharm World Sci2005，27，3： | 1 |
| 9 | Characterization of a novel endopolygalacturonase from Aspergillus niger with unique kinetic properties显示文摘 | Lucie Parenicova Harry C M Kester Jacques A E Benen | 2000 | FEBS Letters2000，467，： | 1 |
| 10 | Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells显示文摘 | Separovic D Kester M Emsberger P | 1996 | Mol Pharmacol1996，49，4： | 1 |
| 11 | Interleukin-1 generation transmembrane signal from phospholipids through novel pathways in cultured rat mesangial cell显示文摘 | Kester M Simonson MS Mene P | 1989 | J Clin Invest1989，83，2： | 1 |
| 12 | Release and phase partitioning of metals from anoxic estuarine sediments during periods of simulated resuspension显示文摘 | CANTWELL M G BURGESS R M KESTER D R | 2002 | Environmental Science & Technology2002，36，24： | 1 |
| 13 | Biomarker reproducibility in exhaled breath condensate collected with different condensers 显示文摘 | Rosias P P Robroeks C M Kester A | 2008 | Eur Respir J2008，31，5： | 1 |
| 14 | Activation of phosphatidylcholine-selective phosphoipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla显示文摘 | Sepaorvic D Kester M Haxhiu M | 1997 | Brain Res1997，749，2： | 1 |
| 15 | Biochemical mechanisms of thyroid hormone deiodination显示文摘 | Kuiper G G Kester M H Peeters R P | 2005 | Thyroid2005，15，8： | 1 |
| 16 | Development and validation of a three-dimensional morphological model显示文摘 | Lesseer G R Roelvink J A van Kester J A T M | 2004 | Coastal Engineering2004，51，： | 1 |
| 17 | Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition 显示文摘 | Goos J D Kester M I Barkhof F | 2009 | Stroke2009，40，11： | 1 |
| 18 | Kinetic characterization of Aspergillus niger N400 endopolygalacturonases Ⅰ,liand C显示文摘 | Jacques A E Benen Harry C M Kester Jaap Visser | 1999 | Eur J Biochem1999，259，： | 1 |
| 19 | Activity of protein kinase C isoenzymes is regulated by I1-imidazoline receptor in PC12 pheochromocytoma cells显示文摘 | Ersberger P Fishman DM Kester M | 1998 | Naunyn-Schmiedebergs Arch Pharmacol1998，358，： | 1 |
| 20 | Contribution of nitrification and denitrification to the NO and N2O emissions of an acid forest soil, a river sediment and a fertilized grassland soil显示文摘 | Kester R A Meijer M E Libochant j A | 1997 | Soil Biology and Biochemistry1997，29，1112： | 1 |
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