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| 1 | 乙酸丁酯反应精馏过程模拟设计(英文)显示文摘反应精馏偶合了反应和精馏两种单元操作,通过精馏促进反应,可以提高反应转化率和收率,为可逆反应的化工过程生产提供了新的设计途径。基于严格热力学分析计算,利用计算机模拟和优化手段。提出了乙酸丁酯反应精馏、分离纯化的生产流程。采用UNIQUAC方程表征乙酸-正丁醇-乙酸丁酯-水四元非理想体系的汽液平衡,首先,根据实验数据回归了热力学模型中的交互作用参数,并预测了体系中5个共沸物组成,模型的计算结果与实际数据吻合。基于平衡级模型,提出了由平衡反应器、反应精馏塔、倾析器和纯化塔构成的可行流程,对提出的设计流程进行了模拟、优化,得到了操作工艺参数。模拟结果对工业过程的设计和改造具有一定的指导意义。 | 李春山 Daisuke Hirabayashi Kenzi Suzuki | 2007 | 计算机与应用化学2007，24，12： | 3 |
| 2 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 3 | Controllable fabrication of carbon aerogels显示文摘Nano-pore carbon aerogels were prepared by the sol-gel polymerization of resorcinol (1,3-dihydroxybenzene)(C6H4(OH)2) with formaldehyde (HCHO) in a slightly basic aqueous solution, followed by super-critical drying under liquid carbon dioxide as super-critical media and carbonization at 700 ℃ under N2 gas atmosphere. The key of the work is to fabricate carbon aerogels with controllable nano-pore structure, which means extremely high surface area and sharp pore size distribution. Aiming to investigate the effects of preparation conditions on the gelation process, the bulk density, and the physical and chemical structure of the resultant carbon aerogels, the molar ratio of R/C (resorcinol to catalyst) and the amount of distilled water were varied, consequently two different sets of samples, with series of R/C ratio and RF/W (Resorcinol-Formaldehyde to water, or the content of reactant) ratio, were prepared. The result of N2 adsorption/desorption experiment at 77 K shows that the pore sizes decreasing from 11.4 down to 2.2 nm with the increasing of the molar ratio of R/C from 100 to 400, and/or, the pore sizes decreasing from 3.8 down to 1.6 nm with the increasing of reactant content from 0.4 to 0.6. | TANEMURA Sakae TANEMURA Masaki SUZUKI Kenzi | 2006 | Rare Metals2006，25，z1： | 2 |
| 4 | Microbiological culture analysis of the tongue anaerobic microflora in subjects with and without halitosis显示文摘 | Donaldson AC Kenzie DM Riggio MP | 2005 | Oral Diseases2005，11，： | 1 |
| 5 | The Facile Synthesis of Quinoxalinyl-2-oxyphenols 显示文摘 | Sakata Oozyo Makino Kenzi Hashida Isao | 1984 | Heteroeycles1984，22，11： | 1 |
| 6 | Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis显示文摘 | Chen Y Langish CL Me Kenzie M | | 0，，05： | 1 |
| 7 | Differential clathrin binding and subcellular localization of splice isoforms显示文摘 | Choudhury R Noakes CJ Mc Kenzie E | 2009 | J Bio Chem2009，284，15： | 1 |
| 8 | Tar property, analysis, re显示文摘 | Chunshan Li Kenzi Suzuki | 2009 | Renewable and Sustainable Energy Reviews2009，13，59： | 1 |
| 9 | ‘SPC136’(Suite NoteTM)sweet cherry显示文摘 | Hampson C Mac Donald R Mc Kenzie DL | 2014 | Canadian Journal of Plant Science2014，94，8： | 1 |
| 10 | Wildfire-produced charcoal directly influences nitrogen cycling in ponderosa pine forests 显示文摘 | Deluca T H Mac Kenzie M D Gundale M J | 2006 | Soil Science Society of America Journal2006，70，： | 1 |
| 11 | Theorphan nuclear receptor ROR gammat directs thedifferentiation program of proinfl ammatory IL-17+T helper cells显示文摘 | Ivanov I I Mc Kenzie B S Zhou L | 2006 | Cell2006，126，25： | 1 |
| 12 | Evaluation of pediatric lower extremity fractures managed with external fixation:outcomes in a deployed environment显示文摘 | Eichinger JK Mc Kenzie CS Devine JG | 2012 | Am J Orthop(Belle Mead NJ)2012，41，1： | 1 |
| 13 | The ex-utero intrapartum treatment显示文摘 | Mac Kenzie TC Crombleholme TM Flake AW | 2002 | Curr Opin Pediatr2002，14，4： | 1 |
| 14 | Glucose determination by a pulsed photoacoustic technique:an experimental study using a gelatin-based tissue phantom显示文摘 | K M Quan G B Christison H A Mac Kenzie P Hodgson | 1993 | Physics in medicine and biology1993，38，12： | 1 |
| 15 | A massive outbreak in Milwaukee of Cryptosporidium infection transmitted through the public water supply显示文摘 | Mac Kenzie WR Hoxie N J Proctor ME | 1994 | N Engl J Med1994，331，3： | 1 |
| 16 | Water-based exercise in COPD with physical comorbidities:a randomised controlled trial显示文摘 | Mc Namara RJ Mc Keough ZJ Mc Kenzie DK | 2013 | Eur Respir J2013，41，6： | 1 |
| 17 | Maintenance of large surface area of alumina heated at elevated temperatures above 1300 ℃ by preparing silica-containing pseudoboehmite aerogel显示文摘 | Tatsuro H Toshihiko O Toyohiko S Kenzi S Toshiaki M | | 0，，： | 1 |
| 18 | A new approach for catheter ablation of atrial fibrillation:mapping of the electrophysiologic substrate显示文摘 | Nademanee K Mc Kenzie J Kosar E | 2004 | J Am Coll Cardiol2004，43，11： | 1 |
| 19 | Photoemission and in-situ XRD investigation on CuCoZnAl-mixed metal oxide catalysts for the oxidation steam reforming of methanol显示文摘 | Velu S Kenzi S Chinnakonda S G | 2002 | Phys Chem B2002，106，12： | 1 |
| 20 | Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotie BH3only molecule bid显示文摘 | Estella E Me Kenzie MD Catterall T | 2006 | Diabetes2006，55，8： | 1 |
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