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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Smoking habits,current symptoms and premorbid characteristics of schizophrenic patients in Nithsdale,Scotland显示文摘 | Kelly C Mc Creadie RG | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 3 | Phase Ⅲ trial evalua- ting weekly paclitaxel versus docetaxel in combination with capecitabine in operable breast cancer显示文摘 | Kelly CM Green MC Broglio K | 2012 | J Clin Oncol2012，30，： | 1 |
| 4 | Atohl directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo显示文摘 | Kelly MC Chang Q Pan A | 2012 | J Neurosci2012，32，19： | 1 |
| 5 | Off-label use of medicines:consensus recommendations for evaluating appropriateness显示文摘 | Gazarian M Kelly M Mc Phee JR | 2006 | M ed J Aust2006，185，10： | 1 |
| 6 | Photodynamic de- struction of human bladder carcinoma 显示文摘 | Kelly JF Snell MF Berenbaum MC | 1975 | Br J Canc- er1975，31，： | 1 |
| 7 | Capecitabine in operable triple receptor-negative breast cancer:A subgroup analysis of a randomized phase III trial显示文摘 | Kelly CM Green MC Broglio K | 2011 | J Clin Oncol2011，，： | 1 |
| 8 | Sympathetic nerve-derived ATP regulatesrenal medullary vasa recta diameter via pericyte cells: a role forregulating medullary blood flow-显示文摘 | Crawford C Wildman SS Kelly MC Kennedy-Lydon TM Peppiatt-Wildman CM | 2013 | Front Physiol2013，4，： | 1 |
| 9 | Modification of the staphylococcus aureus fibronectin binding phenotyoe by V8 protease显示文摘 | Martin JM Zzhradka MC Kelly Rice | 1997 | Infect Immun1997，65，7： | 1 |
| 10 | Nickel(Ⅱ)-catalysed oxidative guanine and DNA damage beyond 8-oxoguanine显示文摘 | Kelly MC Whitaker G White B | 2007 | Free Radic Biol Med2007，42，11： | 1 |
| 11 | Prostaglandin D2 release by endometrium and myometrium显示文摘 | Rees MC Kelly RW | 1986 | Br J Obstet Gynaecol1986，93，10： | 1 |
| 12 | Prevention and treatment of skin aging显示文摘 | Mc Cullough JL Kelly KM | 2006 | Ann N Y Acad Sci2006，1067，： | 1 |
| 13 | Atohl directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo显示文摘 | Kelly MC Chang Q Pan A | 2012 | J Neurosci2012，32，19： | 1 |
| 14 | Canadian Otolaryngology-Head and- Neck Surgery clerkship curricula: evolving toward tomorrow'sleamers 显示文摘 | Kelly K Fung K Mc Lean L | 2013 | J Otolaryngol Head Neck Surg2013，42，1： | 1 |
| 15 | Evaluating patterns of weight and body composition change among college women 显示文摘 | Kelly MC Latner JD | 2015 | Eat Behav2015，17，： | 1 |
| 16 | Effective thermal and elastic properties ofs Laminates显示文摘 | Mc Cartney L N Kelly A | 2007 | Composites Science and Technology2007，67，34： | 1 |
| 17 | Functional role for c-myc in mitogenic response to platelet-derived growth factor 显示文摘 | Armelin HA Armelin MC Kelly K | 1984 | Nature1984，310，5979： | 1 |
| 18 | Heavy metal accumulation an growth of seedlings of five forest species as influenced by soil cadmium level显示文摘 | Kelly J M Parker G R Mc Fee W W | 1979 | Journal of Environmental Quality1979，8，1： | 1 |
| 19 | Differential effects of lower limb revascularisation on organ injury and the role of the amino acid taurine显示文摘 | Barry MC Kelly CJ Abdih H | 1997 | Eur J Vasc Endovasc Surg1997，13，2： | 1 |
| 20 | Some behavioural and neurochemical aspects of sub acute (+/-) 3, 4-methylenedioxy methamphetamine administration in rats显示文摘 | McNamara MC Kelly JP Leonard BE | 1995 | Pharmacol Biochem Behav1995，52，3： | 1 |
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