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| 1 | Primary lymphoma of bone:correlation of magneitic resonance imaging features with cyto kine production by tumor cells显示文摘 | Hicks DG Gokan T O'Keefe RJ | | 0，，04： | 2 |
| 2 | SELEX with modified nucleotides显示文摘 | Keefe A D Cload S T | 2008 | Curr Opin in Chem Biol2008，12，4： | 1 |
| 3 | Disease severity and domain specific arthritis self-efficacy: Relationships to pain and functioning in patients with rheumatoid arthritis显示文摘 | Somers T J Shelby R A Keefe F J | 2010 | Arthritis Care Res ( Hoboken)2010，62，6： | 1 |
| 4 | The self-efficacy of family caregivers for helping cancer patients ma-nage pain at end-of-life显示文摘 | Keefe F J Ahles T A Porter L S | | 0，，1： | 1 |
| 5 | The effect of additives on the nudleation and growth of copper onto stainless steel cathodes 显示文摘 | SUN M KEEFE T J O | 1992 | Metallurgical Transaction B1992，，23： | 1 |
| 6 | The Production of Audit Services:Evidence from a Major Accounting Firm显示文摘 | O'Keefe T Simunic D A Stein M T | 1994 | Journal of Accounting Research1994，32，2： | 1 |
| 7 | Finite element modeling of transverse impact on a ballistic fabric显示文摘 | Duan Y Keefe M Bogetti T A | 2006 | Int J of Mechanical Sciences2006，48，1： | 1 |
| 8 | Compliance with GAAS Reporting Standards:Evidence from a Positive Enforcement Program 显示文摘 | COLBERT G J O'KEEFE T B | 1995 | Auditing : A Journal of Practice and Theory1995，14，2： | 1 |
| 9 | Luminescent sensor molecules based on coordinated metals: a review of recent developments 显示文摘 | Keefe M H Benkstein K H Hupp J T | 2000 | Coord Chem Rev2000，205，： | 1 |
| 10 | Automated test case generation for program specified by relational algebra queries显示文摘 | TSAI W VOLOVIK D KEEFE T | 1990 | IEEE Transactions on Software Engineering1990，16，3： | 1 |
| 11 | Reconciling value estimates from the discounted cash flow model and the residual income model 显示文摘 | LUNDHOLM R O'KEEFE T | 2001 | Contemporary Accounting Research2001，18，2： | 1 |
| 12 | Optimal swimming speeds reflect preferred swimming speeds of brook charr (Salvelinus fontinalis Mitchill, 1874)显示文摘 | Tudorache C O'Keefe R A Benfey T G | 2011 | Fish Physiol Biochem2011，37，2： | 1 |
| 13 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 14 | Oblique impact: A process for obtaining Meteorite samples from other planets显示文摘 | O'Keefe J D Ahrens T J | 1986 | Science1986，234，： | 1 |
| 15 | Hope in the context of lung cancer: relationships of hope to symptoms and psychological distress 显示文摘 | Berendes D Keefe FJ Somers T I | 2010 | J Pain Symptom Manag2010，40，2： | 1 |
| 16 | Age preferences in mates reflect sex differences in human reproductive strategies显示文摘 | Kenrick D T Keefe R C | 1992 | Behavioral and Brain Sciences1992，15，01： | 1 |
| 17 | Chemical and morphological analyses of zinc powders for alkaline batteries显示文摘 | PEREZ M G O'keefe M J O'keefe T | | 0，，01： | 1 |
| 18 | A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis显示文摘 | Busacker A Newell JD Jr Keefe T etc | 2009 | Chest2009，135，1： | 1 |
| 19 | Database concurrency control in multilevel secure database management systems 显示文摘 | Keefe T Tsai W Srivastava J | 1993 | IEEE Trans on Knowledge and Data Engineering1993，5，6： | 1 |
| 20 | Automated test case generation for programs specified by relational algebra queries显示文摘 | Tsaiwt Volovik D Keefe T F | 1990 | IEEE Transaction Software Engineering1990，16，3： | 1 |
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