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| 1 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 2 | Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults显示文摘BACKGROUND Although the association of attention deficit hyperactivity disorder(ADHD)with psychiatric disorders is well known,its association with somatic diseases is unclear.Only few studies have investigated the gastrointestinal(GI)morbidity in adult patients with ADHD.AIM To measure gastrointestinal comorbidity and its burden on healthcare in young adults with ADHD.METHODS The cohort included subjects aged 17-35 years recruited to the Israel Defense Forces in 2007-2013,33380 with ADHD and 355652 without(controls).The groups were compared for functional and inflammatory conditions of the gastrointestinal tract and clinic and specialist visits for gastrointestinal symptoms/disease during service(to 2016).Findings were analyzed by generalized linear models adjusted for background variables.RESULTS Compared to controls,the ADHD group had more diagnoses of functional gastrointestinal disorders(referred to as FGID),namely,dyspepsia[odds ratio(OR):1.48,95%confidence interval(CI):1.40-1.57,P<0.001],chronic constipation(OR:1.64,95%CI:1.48-1.81,P<0.001),and irritable bowel syndrome(OR:1.67,95%CI:1.56-1.80,P<0.001)but not of organic disorders(inflammatory bowel disease,celiac disease).They had more frequent primary care visits for gastrointestinal symptoms[rate ratio(RR):1.25,95%CI:1.24-1.26,P<0.001]and referrals to gastrointestinal specialists(RR:1.96,95%CI:1.88-2.03,P<0.001)and more episodes of recurrent gastrointestinal symptoms(RR:1.29,95%CI:1.21-1.38,P<0.001).Methylphenidate use increased the risk of dyspepsia(OR:1.49,95%CI:1.28-1.73,P<0.001)and constipation(OR:1.42,95%CI:1.09-1.84,P=0.009).CONCLUSION ADHD in young adults is associated with an excess of FGID and increased use of related health services.Research is needed to determine if an integrative approach treating both conditions will benefit these patients and cut costs. | Sivan Kedem Shlomit Yust-Katz Dan Carter Zohar Levi Ron Kedem Adi Dickstein Salah Daher Lior H Katz | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 3 | Optimal Surface Reconstruction from Planar Contours显示文摘 | FUCHS H KEDEM Z M USELTON S P | 1977 | Communication of the ACM1977，20，10： | 1 |
| 4 | Optimal Surface Reconstruction from Planar Contours显示文摘 | Fuchs H Kedem Z M Uselton S P | 1977 | Communication of the ACM1977，10，20： | 1 |
| 5 | Hyperfiltration in charged membranes: the fixed charge model显示文摘 | Hoffer E Kedem O | 1967 | Desalination1967，，2： | 1 |
| 6 | Estimation of the period of periodically correlated sequences显示文摘 | Mart in EKD Kedem B | 1993 | Journal Of Time Series Analysis1993，14，19： | 1 |
| 7 | Negative rejection of acids and separation of ions by hyperfiltmtion显示文摘 | HotTer E Kedem O | 1968 | Desalination1968，，5： | 1 |
| 8 | On visible surface generation bya priori tree structure显示文摘 | Fuchs H Kedem Z M Naylor B F | 1980 | Computer Graphics1980，14，3： | 1 |
| 9 | Thermodynamics Analysis of the Permeability of Biological Membranes to non- electrolytes 显示文摘 | Kedem O Katchalsky A | 1958 | Biochimica Et Biophysica Acta1958，27，： | 1 |
| 10 | Fast detection of common geometric substructure in proteins 显示文摘 | Chew L P Huttenlocher D Kedem Klara | 1999 | ACM RECOMB1999，，： | 1 |
| 11 | Thermodynamics of Hyperfihra- tion (Reverse Osmosis) :Criteria for Efficient Membranes 显示文摘 | Spiegler K Kedem O | 1966 | Desalination1966，1，4： | 1 |
| 12 | On Visible Surface Generation by A Priori Tree Structures 显示文摘 | Fuchs H Kedem Z Naylor B | 1980 | ACM Computer Graphics1980，4，3： | 1 |
| 13 | Thermodynamic analysis of the permeability of biological membranes to non-electrolytes 显示文摘 | Kedem O | 1958 | Biochemica ET Biophysica ACTA1958，27，： | 1 |
| 14 | Anti-Müllerian hormone (AMH) downregulation in late antral stages is impaired in PCOS patients. A study in normo-ovulatory and PCOS patients undergoing in vitro maturation (IVM) treatments显示文摘 | Alon Kedem Ariel Hourvitz Yuval Yung Libby Shalev Gil M. Yerushalmi Hannah Kanety Mirit Hanochi Ettie Maman | 2013 | Gynecological Endocrinology2013，，7： | 1 |
| 15 | Fast detection of common geometric substructure in proteins显示文摘 | Chew LP Huttenlocher D Kedem K | 1999 | J Comput Biol1999，6，： | 1 |
| 16 | Surface modification of commercial polyamide reverse osmosis membranes by radical grafting:an ATR-FT-IR study显示文摘 | BELFER S PURINSON Y KEDEM O | 1998 | Acta Polym1998，49，： | 1 |
| 17 | On goodness of fit of time series models:an application of higher order crossings显示文摘 | KEDEM B SLUD E | 1981 | Biometrika1981，68，2： | 1 |
| 18 | Fast detection of common geometric substructure in proteins显示文摘 | Chew LP Huttenlocher D Kedem K | 1999 | J Comput Biol1999，6，： | 1 |
| 19 | 显示文摘 | Kedem S Schmidt J Paz Y Cohen Y | 2005 | Langmuir2005，21，： | 1 |
| 20 | Estimation of the parameters in stationary autoregressive processes after hard limiting显示文摘 | KEDEM B | 1980 | Journal of the American Statistical Association1980，，： | 1 |
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