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| 1 | Diabetic ke- toacidosis:clinical presentation and precipitating factors at Keny- atta National Hospital, Nairobi 显示文摘 | MBUGUA PK OTIENO CF KAYIMA JK | 2005 | J East Mr Med J2005，82，12： | 1 |
| 2 | Diabetic ketoacidosis:risk factors,mechanisms and management strategies in sub-Saharan Africa:a review显示文摘 | Otieno CF Kayima JK Omonge EO | 2005 | East Afr Med J2005，82，12： | 1 |
| 3 | Platelet functions in patients with meningococcal meningitis at the Kenyatta National Hospital,Nairobi显示文摘 | Amayo EO Kayima JK Joshi MD | 2002 | East Afr Med J2002，79，8： | 1 |
| 4 | Diabetic ketoacidosis:clinical presentation and precipitating factors at Kenyatta National Hospital,Nairobi显示文摘 | Mbugua PK Otieno CF Kayima JK | | 0，，12： | 1 |
| 5 | Treatment of hyperkalemia by altering the transcellular gradient in patients with renal failur eceffect of various therapeutic显示文摘 | Ngugi NN Meligey OS Kayima JK | 1997 | East Ah Med J1997，75，8： | 1 |
| 6 | Diabetic ketoacido- sis: risk factors, mechanisms and management strategies in sub- Saharan Africa: a review 显示文摘 | Otieno CF Kayima JK Omonge EO | 2005 | East Aft Med J2005，82，12： | 1 |
| 7 | Diabetic ketoacidosis:risk factors,mechanisms and management strategies in sub-Sabaran Africa:a review显示文摘 | Otieno CF Kayima JK Omonge EO | 2005 | East Afr Med J2005，82，12： | 1 |
| 8 | Hyperten-sion awareness, treatment and control in Africa : a systemat-ic review显示文摘 | Kayima J Wanyenze R K Katamba A | 2013 | BMC Cardiovasc Disord2013，，13： | 1 |
| 9 | Treatment of hyperkalaemia by altering the transcellular gradient in patients with renal failure: effect of various therapeutic approaches 显示文摘 | NGUGI N MCLIGEYO S O KAYIMA J K | 1997 | East AfrMedJ1997，74，8： | 1 |
| 10 | Concordance between bio-impedance analysis and clinical score in fluid-status assessment of maintenance haemodialysis patients: A single centre experience显示文摘BACKGROUND The burden of chronic kidney disease(CKD)is rising rapidly globally.Fluid overload(FO),an independent predictor of mortality in CKD,should be accurately assessed to guide estimation of the volume of fluid to be removed during haemodialysis(HD).Clinical score(CS)and bio-impedance analysis(BIA)have been utilized in assessment of FO and BIA has demonstrated reproducibility and accuracy in determination of fluid status in patients on HD.There is need to determine the performance of locally-developed CSs in fluid status assessment when evaluated against BIA.AIM To assess the hydration status of patients on maintenance HD using BIA and a CS,as well as to evaluate the performance of that CS against BIA in fluid status assessment.METHODS This was a single-centre,hospital-based cross-sectional study which recruited adult patients with CKD who were on maintenance HD at Kenyatta National Hospital.The patients were aged 18 years and above and had been on maintenance HD for at least 3 mo.Those with pacemakers,metallic implants,or bilateral limbs amputations were excluded.Data on the patients’clinical history,physical examination,and chest radiograph findings were collected.BIA was performed on each of the study participants using the Quantum®II bio-impedance analyser manufactured by RJL Systems together with the BC 4®software.In evaluating the performance of the CS,BIA was considered as the gold standard test.A 2-by-2 table of the participants’fluid status at each of the CS values obtained compared to their paired BIA results was constructed(either++,+-,--or-+for FO using the CS and BIA,respectively).The results from this 2-by-2 table were used to compute the sensitivity and specificity of the CS at the various reference points and subsequently plot a receiver operating characteristic(ROC)curve that was used to determine the best cut-off point.Those above and below the best CS cut-off point as determined by the ROC were classified as being positive and negative for FO,respectively.The proportions of participants diagnosed with FO by the CS and BIA,respectively,were computed and summarized in a 2-by-2 contingency table for comparison.McNemar’s chi-squared test was used to assess any statistically significant difference in proportions of patients diagnosed as having FO by CS and BIA.Logistic regression analysis was conducted to assess whether the variables for the duration of dialysis,the number of missed dialysis sessions,advisement by health care professional on fluid or salt intake,actual fluid intake,the number of anti-hypertensives used,or body mass index were associated with a patient’s odds of having FO as diagnosed by BIA.RESULTS From 100 patients on maintenance HD screened for eligibility,80 were recruited into this study.Seventy-one(88.75%)patients were fluid overloaded when evaluated using BIA with mean extracellular volume of 3.02±1.79 L as opposed to the forty-seven(58.25%)patients who had FO when evaluated using the CS.The difference was significant,with a P value of<0.0001(95%confidence interval:0.1758-0.4242).Using CS,values above 4 were indicative of FO while values less than or equal to 4 denoted the best cut-off for no FO.The sensitivity and specificity for the CS were 63%and 78%respectively.None of the factors evaluated for association with FO showed statistical significance on the multivariable logistic regression model.CONCLUSION FO is very prevalent in patients on chronic HD at the Kenyatta National Hospital.CS detects FO less frequently when compared with BIA.The sensitivity and specificity for the CS were 63%and 78%respectively.None of the factors evaluated for association with FO showed statistical significance on the multivariable logistic regression model. | Kamiti Muchiri Joshua K Kayima Elijah N Ogola Seth McLigeyo Sally W Ndung’u Samuel K Kabinga | 2022 | World Journal of Nephrology2022，11，4： | 1 |
| 11 | asmptomatic bacteriuria among diabetes attending Kenyatta National Hospital显示文摘 | Otieno LS Twahir A | 1996 | East Afr Med J1996，73，： | 1 |
| 12 | Platelet functions in patients with meningococcal meningitis at the Kenyatta National Hospital,Nairobi显示文摘 | Amayo EO Kayima JK Joshi MD | 2002 | East Afr Med Aug2002，79，8： | 1 |
| 13 | Determinants of malaria infections among children in refugee settlements in Uganda during 2018–2019显示文摘Background While 5%of 247 million global malaria cases are reported in Uganda,it is also a top refugee hosting country in Africa,with over 1.36 million refugees.Despite malaria being an emerging challenge for humanitarian response in refugee settlements,little is known about its risk factors.This study aimed to investigate the risk factors for malaria infections among children under 5 years of age in refugee settlements in Uganda.Methods We utilized data from Uganda’s Malaria Indicator Survey which was conducted between December 2018 and February 2019 at the peak of malaria season.In this national survey,household level information was obtained using standardized questionnaires and a total of 7787 children under 5 years of age were tested for malaria using mainly the rapid diagnostic test.We focused on 675 malaria tested children under five in refugee settlements located in Yumbe,Arua,Adjumani,Moyo,Lamwo,Kiryadongo,Kyegegwa,Kamwenge and Isingiro districts.The extracted variables included prevalence of malaria,demographic,social-economic and environmental information.Multivariable logistic regression was used to identify and define the malaria associated risk factors.Results Overall,malaria prevalence in all refugee settlements across the nine hosting districts was 36.6%.Malaria infections were higher in refugee settlements located in Isingiro(98.7%),Kyegegwa(58.6%)and Arua(57.4%)districts.Several risk factors were significantly associated with acquisition of malaria including fetching water from open water sources[adjusted odds ratio(aOR)=1.22,95%CI:0.08–0.59,P=0.002],boreholes(aOR=2.11,95%CI:0.91–4.89,P=0.018)and water tanks(aOR=4.47,95%CI:1.67–11.9,P=0.002).Other factors included pit-latrines(aOR=1.48,95%CI:1.03–2.13,P=0.033),open defecation(aOR=3.29,95%CI:1.54–7.05,P=0.002),lack of insecticide treated bed nets(aOR=1.15,95%CI:0.43–3.13,P=0.003)and knowledge on the causes of malaria(aOR=1.09,95%CI:0.79–1.51,P=0.005).Conclusions The persistence of the malaria infections were mainly due to open water sources,poor hygiene,and lack of preventive measures that enhanced mosquito survival and infection.Malaria elimination in refugee settlements requires an integrated control approach that combines environmental management with other complementary measures like insecticide treated bed nets,indoor residual spraying and awareness. | Henry Musoke Semakula Song Liang Paul Isolo Mukwaya Frank Mugagga Monica Swahn Denis Nseka Hannington Wasswa Patrick Kayima | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
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