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| 1 | Tau-induced neurodegeneration: mechanisms and targets显示文摘The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these post-translational modifi cations can alter tau's biological function. We analyze the role of mitochondrial health in neurodegeneration. We propose that microtubules could be a therapeutic target and review different approaches. Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and propose a mechanism of neurodegeneration. | Cindy Beharry Leah S. Cohen Jing Di Kawsar Ibrahim Susan Briffa-Mirabella Alejandra del C. Alonso | 2014 | Neuroscience Bulletin2014，30，2： | 6 |
| 2 | Design of a Porous Cored Hexagonal Photonic Crystal Fiber Based Optical Sensor With High Relative Sensitivity for Lower Operating Wavelength显示文摘在这篇文章,充实微结构化的 photonic 水晶纤维(PCF ) 的高度敏感、低的监禁损失作为一个光传感器被建议了。建议 PCF 是多孔的 cored 六角形(P-HPCF ) 在 cladding 与圆形的空气包含五层的地方,洞和核心附近由二个分层的椭圆的空气洞被形成。象相对敏感和建议 P-HPCF 的监禁损失那样的二个基本繁殖特征被完整的 vectorial 数字地细看有限元素方法(女性) 模拟过程。优化价值从 0.8 愠敲挠畡敳 ? 祢搠浡条 ? 愠敲愠煣極敲 ? 祢栠杩 ? 灳敥 ? 在波长的一个广阔分类上与象圆形或椭圆的空气洞,核心的程度,和 cladding 区域的直径一样的不同几何参数被修改 ?? 湩整牲杯瑡潩吗? | Shuvo SEN Sawrab CHOWDHURY Kawsar AHMED Sayed ASADUZZAMAN | 2017 | Photonic Sensors2017，7，1： | 4 |
| 3 | Alcohol Sensing Over O+E+S+C+L+U Transmission Band Based on Porous Cored Octagonal Photonic Crystal Fiber显示文摘 | Bikash Kumar PAUL Md. Shadidul ISLAM Kawsar AHMED Sayed ASADUZZAMAN | 2017 | Photonic Sensors2017，7，2： | 3 |
| 4 | Expression of human beta-defensin-2 in intratumoral vascular endothelium and in endothelial cells induced by transforming growth factor beta 显示文摘 | Kawsar HI Ghosh SK Hirsch SA | 2010 | Peptides2010，31，2： | 1 |
| 5 | An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigen- esis显示文摘 | Jin G Kawsar HI Hirsch SA | 2010 | PLoS ONE2010，5，10： | 1 |
| 6 | Design and implementation of a framework for building distributed smart object systems显示文摘 | Kawsar F Nakajima T Park J H el al | 2010 | The Journal of Supercomputing2010，54，1： | 1 |
| 7 | Organization and transcriptional regulation of myo-inositol operon in Clostridium perfringens 显示文摘 | Kawsar H I Ohtani K Okumura K | 2004 | FEMS Microbiol Lett2004，235，： | 1 |
| 8 | Smart objects as building blocks for the Internet of things 显示文摘 | KORTUEM G KAWSAR F FITTON D | 2010 | Internet Computer2010，14，1： | 1 |
| 9 | The VirR/VirS regulatory of cascade affects transcrintion of plasmid en code putative virulence genes in Clostridiurn perfringens strain 13显示文摘 | Ohtani K Kawsar H I Okumura K | 2003 | FEMS Micorbiol Lett2003，222，： | 1 |
| 10 | Hepatitis B re- activation in cancer patients : role of prechemotherapy screening and antiviral prophylaxis显示文摘 | Kawsar HI Shahnewaz J Gopalakrishna KV | 2012 | Clin Adv Hematol oncol2012，10，6： | 1 |
| 11 | Design and Optimization of Photonic Crystal Fiber for Liquid Sensing Applications显示文摘这份报纸为察觉到的液体与高相对的敏感建议六角形的 photonic 水晶纤维(H-PCF ) 结构;在哪个核心和 cladding 是微观结构。数字调查被采用完整的 vectorial 执行有限元素方法(女性) 。分析在建议结构的四个阶段被做了。调查证明建议结构由在 cladding 增加最深处的戒指空气洞的直径完成更高相对的敏感。而且,把一条单个隧道放而不是使用一组微小的隧道有效地增加相对敏感。调查不同参数的效果,优化结构与低监禁损失显示出显著地更高的相对敏感。 | Md. Faizul Huq ARIF Kawsar AHMED Sayed ASADUZZAMAN Md. Abul Kalam AZAD | 2016 | Photonic Sensors2016，6，3： | 1 |
| 12 | Smart ob- jects as building blocks for the Internet of Things显示文摘 | KORTUEM G KAWSAR F FITTON D | 2010 | IEEE Internet Computing2010，14，1： | 1 |
| 13 | Smart objects as building blocks for the In-ternet of things显示文摘 | Kortuem G Kawsar F Fttton D | 2010 | Internet Computer2010，14，1： | 1 |
| 14 | Smart objects as building blocks for the internet of things显示文摘 | KORTUEM G KAWSAR F FITTON D SUNDRAMOORTHY V | | 0，，01： | 1 |
| 15 | Smart objects as build-ing blocks for the Internet of things 显示文摘 | Kortuem G Kawsar F Fitton D | 2010 | IEEE Internet Com-puting2010，14，1： | 1 |
| 16 | An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis显示文摘 | Jin G Kawsar H I Hirsch S A | 2010 | PLoS One2010，5，10： | 1 |
| 17 | Expression of human beta-defensin-2 in intratumoral vascular endothelium and in endothelial cells induced by transforming growth factor beta显示文摘 | KAWSAR H I GHOSH S K HIRSCH S A | 2010 | Peptides2010，31，2： | 1 |
| 18 | Urbanization, Economic Development and Inequality 显示文摘 | KAWSAR M A | 2012 | Bangladesh Research Publications Journal2012，，4： | 1 |
| 19 | An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2,a model for tumorigenesis显示文摘 | Jin G Kawsar HI Hirsch SA | | 0，，6： | 1 |
| 20 | A comparative study of the antioxidant,antimicrobial,cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis显示文摘Objective:To investigate the antioxidant,antimicrobial,cytotoxic and thrombolytic property of the fruits and leaves of Spondias dulcis(S.dulcis).Methods:Methanolic extracts of fruits and leaves of S.dulcis were partitioned with chloroform and dichloromethane.The antioxidant potential of the crude extract and partitioned fractions were evaluated in terms of total phenolic content,total flavonoid content,DPPH radical scavenging potential,reducing potential and total antioxidant capacity by specific standard procedures.The antimicrobial activity was evaluated using disc diffusion method.The cytotoxicity was evaluated by using brine shrimp lethality bioassay and compared with vincristine sulfate.The thrombolytic activity was compared with streptokinase.Results:The methanolic fruit extract exhibited the highest phenolic content,flavonoid content and antioxidant capacity,among the other extracts,with the highest DPPH radical scavenging activity at a concentration of 10μg/mL(IC_(50):1.91μg/mL)and maximum reducing power at a concentration of 100μg/ml.(EC_(50):3.58μg/mL).Though all extract showed moderate antimicrobial activity against the bacterial strains,weak or no activity against fungus.The range of LC_(50)value of all extracts was 1.335-14.057μg/mL which was far lower than the cut off index for cytotoxicity.All extracts exhibited statistically significant(P<0.001)thrombolytic activity.Conclusions:Our study suggested that 5.dulcis exhibits antimicrobial activities against a wide variety of strains while it possesses significant antioxidant,cytotoxic and thrombolytic aclivily. | shawkat Md.Aminul Islam kh Tanvir Ahmed Mohammad Kawsar Manik Md.Arif Wahid chowdhury shafayat ibne Kamal | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 1 |
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