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您的检索式：作者名="Cindy Beharry"
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| 1 | Tau-induced neurodegeneration: mechanisms and targets显示文摘The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these post-translational modifi cations can alter tau's biological function. We analyze the role of mitochondrial health in neurodegeneration. We propose that microtubules could be a therapeutic target and review different approaches. Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and propose a mechanism of neurodegeneration. | Cindy Beharry Leah S. Cohen Jing Di Kawsar Ibrahim Susan Briffa-Mirabella Alejandra del C. Alonso | 2014 | Neuroscience Bulletin2014，30，2： | 6 |
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