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| 1 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 2 | Integrin dependent activation of the JNK signaling pathway by me- chanical stress显示文摘 | PEREIRA A M TUDOR C KANGER J S | 2011 | PLoSOne2011，6，26： | 1 |
| 3 | Asymmetric haeyer-villiger oxidation of cyclobutanones显示文摘 | Lopp M Paju A Kanger T | 1996 | Tetrahedron lett1996，37，42： | 1 |
| 4 | Clinical features and risk factors of pure red cell aplasia following major ABO- incompatible allogeneic hematopoietic stem cell transplantation显示文摘 | Kanger Zhu Jun- ping Li Tao Zhang | 2006 | Blood (ASH Annual Meeting Abstracts)2006，108，： | 1 |
| 5 | Asymmetric oxida- tion of 3-alkyl-1,2-cyclopentaned- iones, Part 2 : Oxida- tive ring cleavage of 3-alkyl-1,2- cyclopentanediones : syn- thesis of 2-alkyl-T-lactoneacids 显示文摘 | Anne P Kanger A Rasmus L | 2003 | Tetrahedron : Asym- metry2003，14，11： | 1 |
| 6 | A note on quantification and modalities显示文摘 | Kanger | 1964 | Theoria1964，，23： | 1 |
| 7 | Patterns of disease failure after trimodality therapy of non-small cell lung carcinoma pathologic stage Ⅲ a( N2 ) 显示文摘 | Kumar P Herndon Ⅱ J Kanger M | 1996 | Cancer1996，77，11： | 1 |
| 8 | Synthesis of (2S,2'S)-Bimorpholine N, N '-Quaternary Dalts as Chiral Phase Transfer Catalysts 显示文摘 | LIPPUR K KANGER T KRIIS K | 2007 | Tetrahedron : Asymmetry2007，18，： | 1 |
| 9 | Integration of microfluidics with a four-channel integrated optical Young interferometer immunosensor显示文摘 | A. Ymeti J.S. Kanger J. Greve G.A.J. Besselink P.V. Lambeck R. Wijn R.G. Heideman | 2004 | Biosensors and Bioelectronics2004，，7： | 1 |
| 10 | Development of a multichannel integrated interferometer immunosensor显示文摘 | Aurel Ymeti Johannes S. Kanger Robert Wijn Paul V. Lambeck Jan Greve | 2002 | Sensors & Actuators: B Chemical (-)2002，，1： | 1 |
| 11 | 白血病骨髓微环境中GATA-1、GATA-2和GATA-3基因表达模式(英文)显示文摘Objective: The aim of the study was to investigate the expression pattern of hematopoietic transcription factor GATA-1, -2 and -3 genes in leukemic bone marrow (BM) microenvironment [including bone marrow stromal cells (BMSCs) and BM hematopoietic cells]. Methods: Mononuclear cells were isolated from BM of patients with acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), or acute lymphoblastic leukemia (ALL). Adherent cells (BMSCs) and nonadherent cells (BM hematopoietic cells) were collected after long-term culture in vitro. The semi-quantitative expression levels of GATA genes in the BMSCs or BM hematopoietic cells from patients with leukemia were analyzed by using RT-PCR-ELISA and compared with normal controls. Results: The expression level of GATA-1 gene in the BMSCs from CML group was significantly lower than that of the normal controls. The expression level of GATA-3 gene in the BMSCs from ALL was higher than that of the normal controls, but that from CML was lower than the normal controls. Dominant expression of GATA-3 gene was found in the normal BM hematopoietic cells. The dominant expression of GATA-2 gene was found in the normal BMSCs and the BMSCs from CML, whereas the dominant expression of GATA-3 gene was detected in the BMSCs from AML. Conclusion: GATA-1, -2 and -3 genes might play a role in hematopoiesis regulation in leukemia, and the changes of expression pattern of GATA genes might influence the hematopoiesis in BM microenvironment and relate to the pathogenesis and development of leukemia. | Xiuli Wu Yangqiu Li Kanger Zhu Zhen Wang Shaohua Chen Lijian Yang Zhongchao Han | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 0 |
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