|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | The relationship between ischemic stroke and weather conditions in Duzce, Turkey显示文摘BACKGROUND: Weather conditions are thought to increase the risk of stroke occurrence. But their mechanism has not yet been clarified. We investigated possible relationships between ischemic stroke and weather conditions including atmospheric pressure, temperature, relative humidity, and wind speed.METHODS: One hundred and twenty-eight patients with ischemic stroke who had been admitted to our hospital between January 1 and December 31, 2010 were enrolled in this study. We investigated the relationship between daily cases and weather conditions the same day or 1, 2, and 3 days before stroke.RESULTS: A negative correlation was found between maximum wind speed and daily cases 3 days before stroke. As the relationship between daily cases and changes of weather conditions in consecutive days was evaluated, a negative correlation was found between daily cases and change of atmospheric pressure in the last 24 hours.CONCLUSIONS: The maximum wind speed 3 days before stroke and change of atmospheric pressure in the last 24 hours were found to increase the cases of ischemic stroke. We recommend that individuals at risk of ischemic stroke should pay more attention to preventive measures, especially on days with low maximum wind speed, on subsequent 3 days, and on days with low atmospheric pressure in the last 24 hours. | Harun Gunes Hayati Kandis Ayhan Saritas Suber Dikici Ramazan Buyukkaya | 2015 | World Journal of Emergency Medicine2015，6，3： | 6 |
| 3 | Acute intoxication cases admitted to the emergency department of a university hospital显示文摘BACKGROUND: This study aimed to describe the clinical and socio-demographic aspects of acute poisoning in 2010 in Duzce City, Northwest Anatolian Region of Turkey.METHODS: Acute poisoning was due to the intentional ingestion of drugs in young and adult people(≥16), who were treated at the Emergency Service of Duzce University Medical Hospital, Turkey from January 1, 2010 to December 31, 2010. In this retrospective and descriptive study, 95 patients were diagnosed with intoxications and 30 of them intentionally ingested drugs to commit suicide. Records of the patients diagnosed with intoxication were obtained from the Clinical Archive of the hospital. Their diagnoses were established according to the International Statistical Classification of Diseases and Related Health Problems. Codes X60-X84 of this classification were used to classify self-infringed drug injuries and drug poisoning.RESULTS: In this series, 35(36.8%) patients were male and 60 patients(63.2%) female. The male/female ratio was 1.0/1.7. The mean age of the patients was 33.1±14.2 years; 17(17.9%) patients were below 20 years old and 9(9.5%) were older than 50 years. Of these patients, 29(30.5%) were single, 7(7.4%) divorced or separated, and 59(62.1%) married. Their mean time for admission to the emergency service after the incident was 208±180(15–660) minutes. The mean time for admission to the emergency service for patients with food intoxication after the incident was 142±160 minutes, for those with drug intoxication 173±161 minutes, for those with carbon monoxide(CO) intoxication 315±209 minutes, and for those with undefined intoxication 289±166 minutes(P=0.005). Most of the intoxication cases occurred in winter(41.1%, 39 of 95 patients). Admissions to the emergency service were most common in December and April(21 and 16 of 95 patients, respectively). Sixty-five(68.4%) cases were involved in non-deliberate poisoning, whereas 30(31.6%) were involved in deliberate poisoning. Twenty-six of the 95 patients with acute poisonings had mortality risk at admission, however only one died from CO intoxication in the emergency service(1.1%). Suicide attempts were more common in females than in males(21 of 30 patients, 70%, P<0.05). CONCLUSION: In Duzce City of Turkey, most intoxication cases occurred in winter, especially in December. They had non-deliberate poisoning, but deliberate poisoning in suicide attempts was more common in females than in males. | Ertugrul Kaya Aylin Yilmaz Ayhan Saritas Serdar Colakoglu Davut Baltaci Hayati Kandis Ismail Hamdi Kara | 2015 | World Journal of Emergency Medicine2015，6，1： | 3 |
| 4 | 氯化钠焙烧-硫酸浸出从白云母矿中提取钾显示文摘本研究旨在采用氯化钠焙烧与-硫酸浸取结合的浸出工艺,从含约10 wt%氧化钾的白云母中提取钾。当仅用硫酸浸出从白云母矿中提取钾时,钾的提取率为8%~18%。获得最大提取率的最佳浸出条件为4 mol/L硫酸,浸出时间为60 min,液固比为4 m L/g。然而,先添加氯化钠焙烧(白云母矿与氯化钠的质量比为1:1,焙烧为900℃,焙烧时间为45 min),然后再用硫酸浸出(浸出温度为95℃,浸出时间为60 min),钾提取率达到98%。在类似的焙烧条件下,仅用硫酸浸出从白云母矿中提取钾,钾提取率仅为60%。分析了温度、时间、氯化钠浓度、硫酸浓度、液固比等焙烧和浸出参数对钾提取的影响。与氯化钠焙烧后白云母中出现的氯化钾物相在硫酸浸出后的残留物中消失,证实了白云母矿石晶体结构的物理和化学变化。依据现有文献,结合X射线衍射和带有能量色散X射线光谱的扫描电子显微镜表征结果,阐明了白云母矿结构中释放钾的可能机制。 | Sandeep Kumar JENA Baijayantimala MOHANTY Geetikamayee PADHY Jogeshwara SAHU Sapan Kumar KANDI | 2022 | Journal of Central South University2022，29，6： | 2 |
| 5 | An analysis of the annual and seasonal trends of air quality index of Delhi显示文摘 | Mohan M Kandy A | | 0，，： | 1 |
| 6 | MiR-125 b regulates cell proliferation and survival in neonatal megakaryocytes 显示文摘 | KANDI R UNDI R GUTI'I R K | 2014 | Ann Hematol2014，93，6： | 1 |
| 7 | The frequency and seasonal variations in juvenile outpatients treated in a dermatology polyclinic显示文摘 | Cicek D Kandi B Oguz S | 2008 | Int J Dermatol2008，47，11： | 1 |
| 8 | Contraindications to nasopharyngeal airway insertion显示文摘 | Diane Bullard Kandie Brothers Charlotte Davis Evelyn Kingsley James Waters | 2012 | Nursing2012，，10： | 1 |
| 9 | Counterfactual intensity显示文摘 | Lawrence J.Sanna Kandi JoTurley‐Ames | 2000 | Eur. J. Soc. Psychol2000，，2： | 1 |
| 10 | The prognostic value of mean platelet volume in deeompensated heart failure 显示文摘 | Kandis H Ozhan H Ordu S | 2011 | Emerg Med J2011，28，： | 1 |
| 11 | The prognostic value of mean plate-let volume in decompensated heart failure显示文摘 | Kandis H Ozhan H Ordu S | 2011 | Emerg Med2011，28，7： | 1 |
| 12 | Combined bilateral asymmetric hip dislocation and anterior shoulder dislocation显示文摘BACKGROUND:Traumatic bilateral hip dislocation is a rare condition.Anterior shoulder dislocation combined with this condition is even a rare occurrence.A 57-year-old man had bilateral asymmetric hip dislocation with a posterior wall fracture of the left acetabulum associated with right shoulder anterior dislocation caused by falling down from a cherry tree.Traumatic hip dislocation and anterior shoulder dislocation represent a true orthopedic emergency.METHODS:Closed reduction was performed immediately for three of the dislocated joints.Posterior wall fracture of the left acetabulum was treated with open reduction and internal fixation by screws.Because of the severity of associated complications like aseptic necrosis or posttraumatic osteoarthritis,efforts were made to ensure prompt diagnosis,therapy and prognosis.RESULTS:The patient was successfully treated by open reduction and internal fixation of the left acetabulum,and discharged from the hospital.CONCLUSION:Traumatic asymmetric hip dislocation and anterior shoulder dislocation are an orthopedic emergency and early diagnosis with immediate reduction of the dislocation is the key determinants of excellent result of treatment. | Mustafa Uslu Mehmet Arican Ayhan Saritas Ramazan Buyukkaya Hayati Kandis | 2012 | World Journal of Emergency Medicine2012，3，4： | 1 |
| 13 | The effect of anemia andRed cell transfusions on mortality in young and elderly intensive carepatients with nosocomial infection显示文摘 | Kutlucan L Kutlucan A Kandis H | 2014 | Leukemia Research2014，38，： | 1 |
| 14 | Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase MI null mutation显示文摘 | Roy B Choudhury A Kandy S | 2001 | J Gastroenterol Hepatol2001，16，18： | 1 |
| 15 | Human nocardia infections : a review of pulmonary nocardiosis 显示文摘 | Kandi V | 2015 | Cureus2015，7，8： | 1 |
| 16 | Synthesis,antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin显示文摘 | MANOHAR S KHAN S I KANDI S K | 2013 | Bioorg Med Chem Lett2013，23，1： | 1 |
| 17 | An urticarial vasculitis case in-duced by glatiramer acetate显示文摘 | Cicek D Kandi B Oguz S | 2008 | J Dermatolog Treat2008，19，5： | 1 |
| 18 | The Development of Organizing Framework to implement AACN Guidelines for Nursing Education显示文摘 | Luann MD Janie BB Kandy KS | 2002 | Journal of Nursing Education2002，41，1： | 1 |
| 19 | MicroRNAs as Haematopoiesis Regulators显示文摘 | Undi RB Kandi R Gutti RK | 2013 | Adv Hematol2013，2013，69： | 1 |
| 20 | Acetaminophen and zinc phosphide for lethal management of invasive lizards Ctenosaura similis显示文摘 | Michael L. AVERY John D. EISEMANN Kandy L. KEACHER Peter J. SAVARIE | 2011 | Current Zoology2011，57，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员