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| 1 | Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L.in guinea-pig显示文摘Objective:To verify the antidiabetic activity of leaf extracts from Physalis peruviana L.popularly used in the Eastern part of the Democratic Republic of the Congo and to point out the possible toxicity.Method:Aqueous decoctions prepared from dried leaves powder were administrated to guinea pigs at the dose range of 100 mg/kg to 3.2 g/kg of body weight.The hypoglycemic activity was evaluated by glucose tolerance test,loading animals with glucose 4 g/kg and measuring blood glucose concentrations at various times.The effect was compared to the control and glibenclamide as antidiabetic reference drug.Acute toxicity was evaluated by recording mortality rate,changes on blood biomarkers and damage caused to vital organs.Results:At a dose of 100 mg/kg,the aqueous extract induced a significant reduction of peak concentration at 30 min after glucose loading as compared with control or reference(P<0.05).At doses greater than 400 mg,some alterations on blood,kidney and liver markers were observed.Upper 800 mg/kg,mortality was observed with LD_(50)estimated at about 1280 mg/kg.At the autopsy,vital organs were in haemorrhage and swelling state.Conclusion:The crude aqueous extracts from the leaves of Physalis peruviana L.present hypoglycemic aclivily in animal model,but at high doses the plant may cause severe intoxication. | Felicien Mushagalusa Kasali Justin Ntokamunda Kadima Pius Tshimankinda Mpiana Koto-te-Nyiwa Ngbolua Damien Sha-Tshibey Tshibangu | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 2 |
| 2 | Defining the ability of cyclophosphamide preconditioning to enhance the antigen- specific CD8 + T-cell response to peptide vaccination : creation of a beneficial host microenvironment involving type I IFNs and mye- loid cells显示文摘 | Salem ML Kadima AN E1-Naggar SA | 2007 | J Immunother2007，30，1： | 1 |
| 3 | Effect of acute Trypanosoma vivax infection on cattle erythrocyte glutathione and susceptibility to in vitro peroxidation显示文摘 | I.O. Igbokwe I.A. Umar J.J. Omage N.D.G. Ibrahim K.B. Kadima O.K. Obagaiye D.I. Saror K.A.N. Esievo | 1996 | Veterinary Parasitology1996，，： | 1 |
| 4 | Structure and geological history of the Congo Basin: an integrated interpretation of gravity, magnetic and reflection seismic data显示文摘 | Kadima E Delvaux D Sebagenzi S N | 2011 | Basin Research2011，23，5： | 1 |
| 5 | Mixed ligand complexes of cadmium, nitrilotriacetic acid, glutathione, and related ligands 显示文摘 | KADIMA W RABENSTEIN D L | 1990 | Inorg Biochem1990，38，5： | 1 |
| 6 | Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling显示文摘 | Salem ML Kadima AN Cole DJ | 2005 | J Immunother2005，28，3： | 1 |
| 7 | Discrepant test findings in Early Infant Diagnosis of HIV in a National Reference Laboratory in Kenya:Challenges and Opportunities for Programs显示文摘 | Kageha S Okoth V Kadima S | 2012 | J Trop Pediatr2012，58，4： | 1 |
| 8 | Systemic administration of IL-15 Janments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells显示文摘 | Rubinstein MP Kadima AN Salem ML | 2002 | J Immunol2002，169，9： | 1 |
| 9 | Discrepant test findings in Early Infant Diagnosis of HIV in a National Reference Laboratory in Kenya: Challenges and Opportunities for Programs 显示文摘 | Kageha S Okoth V Kadima S | 2012 | J Trop Pediatr2012，58，4： | 1 |
| 10 | Mechanism of suppressio of piperacillin resistanc in enterobacteria by tazobactam显示文摘 | Kadima TA Weiner JH | 1997 | Antimicrob Agents Chemother1997，41，： | 1 |
| 11 | A quantitative study of the complexation of cadmium in hemolyzed human erythrocytes by 1H NMR spectroscopy 显示文摘 | Kadima W Rabenstein DL | 1990 | J Inorg Biochem1990，40，2： | 1 |
| 12 | Mechanism of suppression of piperacillin resistance in enter obacteria by tazobactam 显示文摘 | Kadima TA Weiner JH | 1997 | Antimicrob Agents Chemother1997，41，： | 1 |
| 13 | Role of metal ions in the T- to R-allosteric transition in the insulin hexamer显示文摘 | Kadima W | 1999 | Biochemistry1999，38，13： | 1 |
| 14 | The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly( I: C) on antigen-specific CD8 + T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu 显示文摘 | Salem M L EL-Naggar S A Kadima A | 2006 | Vaccine2006，24，： | 1 |
| 15 | Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling:evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity显示文摘 | Salem ML Kadima AN Gole DJ | 2005 | J Immunother2005，28，3： | 1 |
| 16 | Mechanism of suppression of pipenccillin resistance in Enterobacteria by tozobactam 显示文摘 | Kadima TA Weiner JH | 1997 | Antimicrob Agents Chemother1997，41，10： | 1 |
| 17 | Mechanism of suppression of pipenccillin resistance in Enterobacteria by oobactam显示文摘 | Kadima TA Weiner JH | 1997 | Antimicrob Agents Chemother1997，41，10： | 1 |
| 18 | Structure and geological history of the Congo Basin: an integrated interpretation of gravity, magnetic and reflection seismic data 显示文摘 | Kadima E Delvaux D Sebagenzi S N | 2011 | Basin Research2011，23，5： | 1 |
| 19 | Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine显示文摘 | Salem M L Kadima A N Zhou Y | 2004 | J Immunol2004，172，9： | 1 |
| 20 | Systemic administration of IL-15 augments the antigen-specific primary CD8+T cell response following vaccination with peptidepulsed dendritic cells显示文摘 | Kadima AN Salem ML | 2002 | Immunology2002，169，9： | 1 |
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