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| 1 | A topologically substituted boron nitride hybrid aerogel for highly selective CO2 uptake显示文摘A topologically mediated synthesis of porous boron nitride aerogel has been experimentally and theoretically investigated for carbon dioxide (CO2)uptake. Replacement of the carbon atoms in a precursor aerogel of graphene oxide and carbon nanotubes was achieved using an elemental substitution reaction,to obtain a boron and nitrogen framework.The newly prepared BN aerogel possessed a specific surface area of 716.56m^2/g and exhibited an unprecedented twenty- fold increase in CO2uptake over N2,adsorbing 100cc/g at 273K and 80cc/g in ambient conditions,as verified by adsorption isotherms via the multipoint Brunauer-Emmett-Teller (BET)method.Density functional theory calculations were performed to give hints on the mechanism of such high selectivity of CO2 over N2adsorption in BN aerogel,which may be due to the interaction between the intrinsic polar nature of B-N bonds and the high quadrupole moment of CO2 over N2. | R.Govindan Kutty Sivaramapanicker Sreejith Xianghua Kong Haiyong He Hong Wang Junhao Lin Kazu Suenaga Chwee Teck Lim Yanli Zhao Wei Ji Zheng Liu | 2018 | Nano Research2018，11，12： | 5 |
| 2 | A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode显示文摘Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. This method is capable of separating all the related substances of Linezolid along with the chiral impurity. This method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. The method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. The eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability. | T.Satyanarayana Raju O.Vishweshwari Kutty V.Ganesh P.Yadagiri Swamy | 2012 | Journal of Pharmaceutical Analysis2012，2，4： | 4 |
| 3 | Genetic transformation of strawberry by Agrobacterium tumefaciens using a leaf disk regeneration system显示文摘 | Narender S. Nehra Ravindra N. Chibbar Kutty K. Kartha Raju S. S. Datla William L. Crosby Cecil Stushnoff | 1990 | Plant Cell Reports1990，，6： | 2 |
| 4 | Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation:A novel approach to atherosclerosis therapy显示文摘Toll-like receptor 3(TLR3),as an important pattern recognition receptor(PRR),dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.Atherosclerosis is proved as an inflammatory disease,and inflammatory events involved in the entire process of initiation and deterioration.However,the contribution of TLR3 to atherosclerosis remains unclear.Herein,we identified the clinical relevance of TLR3 upregulation and disease processes in human atherosclerosis.Besides,activation of TLR3 also directly led to significant expression of atherogenic chemokines and adhesion molecules.Conversely,silencing TLR3 inhibited the uptake of oxLDL by macrophages and significantly reduced foam cell formation.Given the aberrance in TLR3 functions on atherosclerosis progression,we hypothesized that TLR3 could serve as novel target for clinical atherosclerosis therapy.Therefore,we developed the novel ellipticine derivative SMU-CX24,which specifically inhibited TLR3(IC_(50)=18.87±2.21 nmol/L).In vivo,atherosclerotic burden was alleviated in Western diet fed ApoE^(−/−)mice in response to SMU-CX24 treatment,accompanying notable reductions in TLR3 expression and inflammation infiltration within atherosclerotic lesion.Thus,for the first time,we revealed that pharmacological downregulation of TLR3 with specific inhibitor regenerated inflammatory environment to counteract atherosclerosis progression,thereby proposing a new strategy and probe for atherosclerosis therapy. | Xiaohong Cen Baoqu Wang Yuqing Liang Yanlin Chen Yu Xiao Shaohua Du Kutty Selva Nandakumar Hang Yin Shuwen Liu Kui Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | 高强度炎症反应诱导关节软骨特异性瓜氨酸化抗原表达显示文摘目的探讨关节软骨蛋白瓜氨酸表位的表达情况,以及瓜氨酸化表位对抗瓜氨酸蛋白抗体(ACPAs)的免疫应答的影响。方法体外诱导实验:实验组加不同浓度梯度的脂多糖、热灭活细菌(大肠杆菌、金色葡萄球菌)或二型胶原(CII)特异性单克隆抗体等不同刺激物诱导体外培养关节软骨蛋白瓜氨酸化,等量PBS作为对照组,利用特异性结合瓜氨酸化表位的单克隆抗体ACC4(IgG1)进行免疫组织化学染色,ACC1(IgG2a)作为阳性对照,Hy2.15(IgG1)和L243(IgG2a)分别作为同型阴性对照,显微镜下观察瓜氨酸化蛋白表达;体内诱导实验:SD大鼠右膝关节内注射不同浓度脂多糖作为实验组,左膝关节内注射等量PBS为对照组,3 d后取膝关节组织,制成冰冻切片,利用上述抗体进行免疫组化染色,显微镜下观察瓜氨酸化蛋白表达;建立不同种系的胶原诱导性关节炎(CIA)小鼠模型,评价其疾病发生率和严重程度,同时收集小鼠血清与高滴度抗瓜氨酸化抗体的类风湿性关节炎患者血清,采用液相芯片技术检测小鼠及类风湿患者血清中抗瓜氨酸化蛋白抗体水平,并用免疫组织化学检测关节炎小鼠关节软骨瓜氨酸化蛋白的表达水平。结果特异性结合瓜氨酸化CII表位的ACC4抗体未能结合至经不同诱导的关节软骨组织;与健康对照组相比,ACC4抗体和含高滴度的抗瓜氨酸化蛋白抗体的类风湿性关节炎患者血清中的抗体均能结合至CIA小鼠关节炎症关节软骨周围的滑膜组织;成功构建不同种系小鼠类风湿性关节炎模型,其发病率和疾病严重程度无统计学差异(P>0.05);液相芯片技术分析结果显示,小鼠血清中的抗瓜氨酸化抗体低表达或几乎不表达,但抗CII三螺旋结构多肽的抗体反应性较强。结论轻度急性炎症反应不足以引起关节软骨蛋白瓜氨酸化,其特异性抗原表位的表达需要高强度的炎症反应。二型胶原诱导的小鼠关节炎模型中炎症关节软骨蛋白可表达瓜氨酸化抗原表位,但瓜氨酸化抗原表位的表达不足以引起小鼠体内抗瓜氨酸化抗体的免疫应答,其免疫应答需要更多的刺激信号来诱导。 | 覃桂城 林晓吟 梁培彬 李艳鹏 周春 Kutty Selva Nandakumar Rikard Holmdahl | 2020 | 南方医科大学学报2020，40，8： | 2 |
| 6 | Resolution of the rat brain heine oxygenase activity: absence of a detectable amount of the inducible form (HO-1) 显示文摘 | Trakshel G M Kutty R K Maines M D | 1988 | Arch Biechem Biophys1988，260，： | 1 |
| 7 | Actinide immobilization in crystalline matrix:A study of uranium incorporation in gadolinium zirconate显示文摘 | KUTTY K V G ASUVATHRANMAN R A MADHAVAN R R | 2005 | J Phys Chem Solids2005，66，： | 1 |
| 8 | Idiopathic infantile arterial calcification: a case report of prenatal and postnatal echocardiographic diagnosis显示文摘 | Kutty S Cava JR Frommelt MA | 2009 | Echocardiography2009，26，7： | 1 |
| 9 | Simula- tion of chloride migration in compression - induced damage inconcrete显示文摘 | RAHMAN MK AL - KUTTI WA SHAZALI M | 2012 | J Mater Civil Eng2012，24，7： | 1 |
| 10 | Analysis of variation in tandem repeats in the intron of the major surface glycoprotein expression site of the human form of Pneumocystis carinii显示文摘 | Kutty G Jia Q | 2002 | J Infect Dis2002，186，： | 1 |
| 11 | Efficiency and safety of low-dose as-pirin in polycythemia vera显示文摘 | Landolfi R Marchioli R Kutti J | 2004 | N EnglJ Med2004，350，2： | 1 |
| 12 | Nanoparticles of Sr TiO3 prepared by gel to crystallite conversion and their photocatalytic activity in the mineralization of phenol显示文摘 | Ahuja S Kutty T R N | 1996 | Journal of Photochemistry and Photobiology1996，97，2： | 1 |
| 13 | Hot hardness and indentation creep study on A1-5% Mg alloy ma- trix-B4C particle reinforced composites 显示文摘 | KHAN K B KUTTY TRG SURAPPA M K | 2006 | Materials Science and Engineering2006，，427： | 1 |
| 14 | Circadian-dependent retinal light damage in rats显示文摘 | Orgnisciak DT Darrow RM Barsalou L Kutty RK Wiggert B | 2000 | Invest Ophthalm ol Vis Sci2000，41，12： | 1 |
| 15 | Health care-associat- ed measles outbreak in the United States After an Importa- tion: Challenges and Economic Impact 显示文摘 | Chen SY Anderson S Kutty PK | 2011 | J Infect Dis2011，203，11： | 1 |
| 16 | Influence ofsalinity and temperature on the oxygen consumption in youngjuveniles of the Indian prawn Penaeus indicus显示文摘 | Kutty M N Murugapoopathy G Krishnan T S | 1971 | Mar Biol1971，11，： | 1 |
| 17 | Efficacy and safety of low- dose aspirin in polycythemia vera 显示文摘 | Landoffi R Marchioli R Kutti J | 2004 | N Engl J Med2004，350，2： | 1 |
| 18 | Efficacy and safety of low-dose aspirin in polycythemia vera 显示文摘 | Landolfi R Marchioli R Kutti J | 2004 | N Engl J Med2004，350，2： | 1 |
| 19 | The use of uncementedextensively porous-coated femoral componentsin the management of Vancouver B2 and B3 periprostheticfemoral fractures显示文摘 | O'Shea K Quinlan J F Kutty S | | 0，，12： | 1 |
| 20 | Metastable phase rdations and europium (II) luminescence of barium hexa-aluminates prepared by gel to crystallite conversion显示文摘 | Kutty T R N Nayak M | 1995 | Materials Researck Bulletin1995，30，3： | 1 |
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