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| 1 | Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma显示文摘AIM To investigate the effect of lycopene extracted from tomatoes(LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine(NDEA)-induced hepatocarcinogenesis. METHODS Female BALB/c mice were randomly divided into four groups: The Control, NDEA(200 mg NDEA/kg b.w. given i.p.), LycT(5 mg/kg b.w. given orally on alternate days) and Lyc T + NDEA group. The m RNA and protein expression of various cell proliferation markers(PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd.(India). RESULTS Uncontrolled proliferation in the liver of NDEA(P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes(PCNA, Cyclin D1, and p21) when compared to control and Lyc T mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphatedehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control(P ≤ 0.001) and Lyc T(P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. Lyc T pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the Lyc T + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma(HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group. CONCLUSION This study demonstrates that dietary supplementation with Lyc T has a multidimensional role in preventing HCC development. | Prachi Gupta Nisha Bhatia Mohinder Pal Bansal Ashwani Koul | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Comparison of two different methods of preoperative marking for toric intraocular lens implantation: bubble marker versus pendulum marker显示文摘AIM: To compare the accuracy of two different methods of preoperative marking for toric intraocular lens(IOL) implantation, bubble marker versus pendulum marker, as a means of establishing the reference point for the final alignment of the toric IOL to achieve an outcome as close as possible to emmetropia.·METHODS: Toric IOLs were implanted in 180 eyes of110 patients. One group(55 patients) had preoperative marking of both eyes done with bubble marker(ASICO AE-2791TBL) and the other group(55 patients) with pendulum marker(Rumex 誖 3-193). Reference marks were placed at 3-, 6-, and 9-o'clock positions on the limbus. Slit-lamp photographs were analyzed using Adobe Photoshop(version 7.0). Amount of alignment error(in degrees) induced in each group was measured.· RESULTS: Mean absolute rotation error in the preoperative marking in the horizontal axis was 2.42±1.71 in the bubble marker group and 2.83 ±2.31 in the pendulum marker group(P =0.501). Sixty percent of the pendulum group and 70% of the bubble group had rotation error ≤3(P =0.589), and 90% eyes of the pendulum group and 96.7% of the bubble group had rotation error ≤5(P =0.612).·CONCLUSION: Both preoperative marking techniques result in approximately 3 of alignment error. Both marking techniques are simple, predictable, reproducible and easy to perform. | Javed Hussain Farooqui Archana Koul Ranjan Dutta Noshir Minoo Shroff | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 3 | Ameliorative effects of proline on salt stress-induced lipid peroxidation in cell lines of groundnut ( Arachis hypogaea L.)显示文摘 | M. Jain G. Mathur S. Koul N. Sarin | 2001 | Plant Cell Reports2001，，5： | 2 |
| 4 | Benzophenanthridine alkaloids from Corydalis flabellata 显示文摘 | KOUL S RAZDAN T K ANDOTRA C S KALLA A K KOUL S TANEJA S C | 2002 | Planta Medica2002，68，3： | 1 |
| 5 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 6 | Charac- teristic promoter hypermethylation signatures in male germ cell tumors显示文摘 | Koul S Houldsworth J Mansukhani MM | 2002 | Mol Cancer2002，1，1： | 1 |
| 7 | Diarylquinolines target subunit c of mycobacterial ATP synthase显示文摘 | Koul A Dendouga N Vergauwen K | 2007 | Nat Chem Biol2007，3，6： | 1 |
| 8 | Asymptotics of M-estimators in two-phase linear regression models显示文摘 | Koul H L Qian L Surgailis D | 2003 | Stochastic Processes and Their Applications2003，103，1： | 1 |
| 9 | Property and microstructure evaluation as a function of processing parameters : Large HY-80 steel casting for a US Navy submarine 显示文摘 | Holthaus John E Michelle G Koul | 2006 | Engineering Failure Analysis2006，13，： | 1 |
| 10 | Regulation of AKT/PKB action,celluar growth,and apoptosis in prostate carcinoma cells by MMAC/PTEN显示文摘 | Davies MA Koul D Dhesi H | 1999 | Cancer Res1999，59，11： | 1 |
| 11 | Insecticidal and antifeedant bioactivities of neem oil and their relationship to azadirachtin content 显示文摘 | ISMAN M B KOUL O LUCAYNSKI A | 1990 | J Agric Food Chem1990，38，6： | 1 |
| 12 | Efficient SpuriousRejection and Null Steering Using Slot Antennas 显示文摘 | Parihar M S Basu A Koul S K | 2011 | IEEE Antennas and Wireless Propagation Letters2011，10，1： | 1 |
| 13 | Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma 显示文摘 | Koul D Shen R Kim YW | 2010 | Neuro Oncol2010，12，6： | 1 |
| 14 | Lightweight materials for aircraft applications 显示文摘 | IMMARIGEON J P HOLT R T KOUL A K ZHAO L WALLACE W BEDDOES J C | 1995 | Material Characterization1995，35，1： | 1 |
| 15 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 16 | MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer显示文摘 | Koul D Shen R Garyali A | 2002 | Int J Oncol2002，21，3： | 1 |
| 17 | Development and validation of molecular markers linked to an Aegilops umbellulata-derived leaf-rust-resistance gene, Lr9, for marker-assisted selection in bread wheat显示文摘 | Gupta S K Charpe A Koul S | 2005 | Genome2005，48，： | 1 |
| 18 | Transient apical ballooning:sheep in wolves' garb显示文摘 | Dhar S Koul D Subramanian S | 2007 | Cardiol Rev2007，15，3： | 1 |
| 19 | Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer显示文摘 | Koul R Dufan T Russell C | 2007 | Int J Radiat Oncol Biol Phys2007，，3： | 1 |
| 20 | Lightweight materials for aircraft applications 显示文摘 | HOLT R T KOUL A K ZHAO L WALLACE W BEDDOES J C IMMARIGEON J P | 1995 | Materials Characterization1995，35，1： | 1 |
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