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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 3 | 25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures显示文摘Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits. | DANIEL BENEDIKOVIC LéOPOLD VIROT GUY AUBIN FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN | 2019 | Photonics Research2019，7，4： | 2 |
| 4 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography显示文摘 | Stephen Schroeder Andreas F Kopp Axel Kuettner Christof Burgstahler Christian Herdeg Martin Heuschmid Andreas Baumbach Claus D Claussen Karl R Karsch Ludger Seipel | 2002 | Clinical Imaging2002，，2： | 2 |
| 5 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography:experience in 94 patients显示文摘 | Kopp Andreas F Kuettner Axel | 2002 | Clin Imaging2002，26，2： | 1 |
| 6 | Omission of e- lective node irradiation on basis of CT - scans in patients with limited disease small cell lung cancer:A phase I1 trial显示文摘 | De Ruysscher D Bremer RH Koppe F | 2006 | Radiother Onco12006，80，3： | 1 |
| 7 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 显示文摘 | Schroeder S Kopp A F Baumbach A | 2001 | J Am Coil Caudiol2001，37，5： | 1 |
| 8 | Non-invasive coronary angiography with high resolution multidetector-row computed tomography: results in 102 patients显示文摘 | Kopp A F Schroeder S Kuettner A | 2002 | Eur Heart J2002，23，21： | 1 |
| 9 | Uncertain estimate in resources assessment: A geostatistical contribution 显示文摘 | Souza L E Costa J F C L Koppe J C | 2004 | Natural Resources Research2004，13，1： | 1 |
| 10 | Neural control of renal function显示文摘 | Dibona G F Kopp U C | 1997 | Physiological Rev1997，77，1： | 1 |
| 11 | Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes显示文摘 | Jin DK Shido K Kopp HG Petit I Shmelkov SV Young LM Hooper AT Amano H Avecilla ST Heissig B Hattori K Zhang F | 2006 | Nat Med2006，12，： | 1 |
| 12 | Site-selection model foroptimal transplantation of eelgrass Zostera marina in the northeast-ern US显示文摘 | Short F T Davis R C Kopp B S | 2002 | Marine Ecology Progress Series2002，227，： | 1 |
| 13 | Virtual coronary an-gioscopy using multislice computed tomography 显示文摘 | Schroeder S? Kopp A F Ohnesorge B | 2002 | Br Med J2002，87，3： | 1 |
| 14 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography:experience in 94 patients显示文摘 | Schroeder S Kopp A F Kuettner A | 2002 | Clin Imageing2002，26，2： | 1 |
| 15 | Coronary arteries: retrospectively ECG-gated multi-detector row CT angiography with selective optimization of the image reconstruction window显示文摘 | Kopp A F Schroeder S Kuettner A | 2001 | Radiology2001，221，： | 1 |
| 16 | Epidemiology of Hoffmeister's genetically determined predisposition to disturbed development of the dentition in patients with true skeletal Class III malocclusion显示文摘 | Stahl F Kopp H Feldmann H | 2005 | J Orofac Orthop2005，66，1： | 1 |
| 17 | Non-invasive coronary angiography with high resolution multi-detector row computed tomography 显示文摘 | Kopp A F Schroeder S Kuettner A | 2002 | Eur Heart J2002，23，： | 1 |
| 18 | Thin-strip casting-modelling of the combined casting: metal-forming process 显示文摘 | Kopp R Hagemann F Hentschel L | 1998 | Journal of Materials Processing Technology1998，，8081： | 1 |
| 19 | Neural control of renal function 显示文摘 | Dibona G F Kopp U C | 1997 | Physiol Rev1997，77，1： | 1 |
| 20 | Non - invasive characterisation of coronary lesion morphology and composition by multislice CT: First results in comparison with intracoronary ultrasound显示文摘 | Schroeder S Baumbach A | 2001 | Eur Radiol2001，11，9： | 1 |
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