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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Effects of flue-curing and ageing on the volatile,natural and acidic constituents of Virginia tobacco显示文摘 | Wahlberg I Kerstin K Austin D J | 1977 | Pyhtochemistry1977，16，： | 1 |
| 3 | Urapidil dose not prevent postanesthetic shivering: a dose-ranging study 显示文摘 | Swen N Kerstin D Kerstin D | 2001 | Can Anesth2001，48，： | 1 |
| 4 | Effects of flue-curing and ageing on the volatile,neutral and acidic constituents of Virginia tobacco显示文摘 | Wahlberg I Kerstin K Austin D J | 1977 | Pyhto- chemistry1977，16，： | 1 |
| 5 | New insights into the glycosylation of the surface layer protein SgsE from geobacillus stearothermophilus NRS 2004/3a 显示文摘 | Kerstin S Gottfried P Klaus D | 2006 | J Bacteriol2006，188，22： | 1 |
| 6 | Urapidil dose not prevent postanesthetic shivering: adose - ranging study 显示文摘 | SWEN N MORITZ T KERSTIN D | 2001 | Can Anesth2001，48，： | 1 |
| 7 | Urapidil does not prevent postanesthetic shivering:adose-ranging study显示文摘 | SWEN N MORRITZ T KERSTIN D | 2001 | Can Anesth2001，48，： | 1 |
| 8 | Characteristics of amino acid uptake in barley显示文摘 | Sandra J Torgny N Kerstin H D | 2008 | Plant and Soil2008，302，： | 1 |
| 9 | Siliconinduced basal resistance in tomato against Ralstonia solanacearum is related to modification of pectic cell wall polysaccharide structure显示文摘 | Redrigue V C D Kerstin W | 2007 | Physiological and Molecular Plant Pathology2007，70，46： | 1 |
| 10 | Nutritional status using Mini Nutritional Assessment and Subjective Global Assessment predict mortality in geriatric patients 显示文摘 | Margareta D Kerstin E Krassimir S | 2002 | J Am Geriatr Soc2002，50，12： | 1 |
| 11 | Urapidil dose not prevent postanesthetic shivering: adose - ranging study 显示文摘 | SWEN N MORITZ T KERSTIN D | 2001 | Can Anesth2001，48，： | 1 |
| 12 | Effects of flue-curing and ageing on the volatile, neutral and acidic constituents of Virginia tobacco显示文摘 | Wahlberg I Kerstin K Austin D J | 1977 | Pyhtochemistry1977，16，： | 1 |
| 13 | Nutritional status using Mini Nutritional Assessment and Subjective Global Assessment predict mortalith in geriatric patients显示文摘 | Margareta D Kerstin E Krassimir S | 2002 | J Am Geriatr Soc2002，50，12： | 1 |
| 14 | Long-term drought stress alters nitrogenase activity and carbon translocation in split-root cultured Alnus incana显示文摘 | Sundstrom K R H D Kerstin | 1995 | Physiol Plant1995，94，： | 1 |
| 15 | Effects of flue-curing and ageing on the volatile, neutral and acidic constituents of Virginia tobacco显示文摘 | Wahlberg I Kerstin K Austin D J | 1977 | Pyhtochemistry1977，16，： | 1 |
| 16 | Angiostatin and endostatin inhibit endothelial cell migration in res -ponse to FGF and VEGF without interfering with specific intracellular signal transductionpathways显示文摘 | Kerstin E Peetra M Johan D | 2003 | FEBS Leters2003，536，3： | 1 |
| 17 | Skin-to-skin care with the father after cesarean birth and its effect on newbon crying and prefeeding behavior显示文摘 | Kerstin E Ann D lngegerd F | 2007 | Birth2007，34，2： | 1 |
| 18 | Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats显示文摘 | Andreas Plagemann Thomas Harder Kerstin Melchior Annett Rake Wolfgang Rohde Günter D?rner | 1999 | NeuroReport1999，，15： | 1 |
| 19 | A common role of insula in feelings, empathy and uncertainty 显示文摘 | TANIA S HUGO D C KERSTIN P | 2009 | Cell2009，13，8： | 1 |
| 20 | Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells显示文摘 | JANE S KAROLINA A KERSTIN D | 2008 | Stem Cells2008，26，7： | 1 |
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