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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 3 | Meteor: a constraint-based FIR filter design program显示文摘 | KENNETH S THOMAS W P JAMES F K | 1992 | IEEE Transactions on Signal Processing1992，40，8： | 1 |
| 4 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 5 | Phosphorylated tau and the neurodegenerative foldopathies显示文摘 | Kenneth S K Hideki S | 2005 | (BBA)-Molecular Basis of Dis2005，1739，： | 1 |
| 6 | Late Cretaceous and Cenozoic sea level estimates: Back stripping analysis of borehole data, onshore New Jersey显示文摘 | William A V S Michelle A K Kenneth G M | 2004 | Basin Re search2004，16，： | 1 |
| 7 | Vaporliquid phase equilibria of potassium chloride-water mixtures:Equation-of-state representation for potassium chloride-water and sodium chloride-water显示文摘 | Jamey K Hovey Kenneth S Pitzer John C Tanger | 1990 | The Journal of Physical Chemistry1990，94，3： | 1 |
| 8 | Achieving relationship marketing effectiveneas in business-to-busineas exchanges显示文摘 | ROBERT P W LISA'S K KENNETH R | 2008 | Journal of the Acadmy of Science Sunmmer2008，36，2： | 1 |
| 9 | Pdxl and other factors that regulate pancre- atic D-cell survival 显示文摘 | Fujimoto K Kenneth S | 2009 | Diabetes Obes Metab2009，11，4： | 1 |
| 10 | Soft rot erwiniae:from genes to genomes显示文摘 | Ian K Kenneth S B Maria C H | 2002 | Mol Plant Pathol2002，，4： | 1 |
| 11 | Mandatory steroid testing of high school athletes:A synthesis of state ini- tiatives and federal constitutional rights显示文摘 | KENNETH J S KEITH M C SHANTEL R K | 2012 | J Legal Aspects Sport2012，，21： | 1 |
| 12 | Conceptualization,Characterization and Numerical Modeling of the Jeckson Hole Alluvial Aquifer Using Arc Info and Modflow 显示文摘 | Carma S J Kenneth K E | 1996 | Engineering Geology1996，42，23： | 1 |
| 13 | Pancreaticoduodenal transplantation in the rat显示文摘 | SUN L E E KENNETH S K T KOOPMANS H | 1972 | Transplantation1972，13，4： | 1 |
| 14 | The Effects of Attitudinal and Demographic Factors on Intention to Buy Pirated CDs:The Case of Chinese Consumers显示文摘 | KENNETH K KWONG OLIVER H M YAU JENNY S Y LEE etc | 2003 | Journal of Business Ethics2003，47，： | 1 |
| 15 | Stress: metaplastic effects in the hippocampus 显示文摘 | Jeansok J K Kenneth S Y | 1998 | Trends in Neuroseienees1998，21，12： | 1 |
| 16 | Recent pro- gress in the understanding of the structure-fuetion re- lationships o{ the globular head regions of Clq 显示文摘 | Kishore U Mihaela S K Kenneth B M R | 2002 | Immunobiol2002，205，45： | 1 |
| 17 | Number of visits andlength of each visit to a nipple cup drinker by 7-week-old pigs af-ter a water deprivation period or ad libitum access to water显示文摘 | Ciara J J Locke A K Kenneth J S | 2009 | Journal of Swine Health and Production2009，17，2： | 1 |
| 18 | Superhydrophobic carbron narbon nanotube forests显示文摘 | Kenneth K S Jose Bico Kenneth B K T | 2003 | Nano Letters2003，3，12： | 1 |
| 19 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，3： | 1 |
| 20 | Desloratadine therapy for symptoms associated with perennial allergic rhinitis 显示文摘 | KENNETH K GORDON S JACQUES H | 2006 | Ann Allergy Asthma Immunol2006，96，： | 1 |
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