|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-invasive fibrosis assessment in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is estimated to affect approximately 25%of the adult population worldwide.[1]NAFLD encompasses a histopathological spectrum of progressive pathologic conditions ranging from non-alcoholic fatty liver(NAFL)to steatohepatitis(NASH)and cirrhosis. | Rafael S.Rios Kenneth I Zheng Giovanni Targher Christopher D.Byrne Ming-Hua Zheng | 2020 | Chinese Medical Journal2020，，22： | 4 |
| 2 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 3 | LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver显示文摘Background: Nonalcoholic fatty liver disease(NAFLD) is one of the main liver diseases, and its pathologic profile includes nonalcoholic fatty liver(NAFL) and nonalcoholic steatohepatitis(NASH). However, there is no reliable non-invasive parameter in distinguishing NASH from NAFL in clinical practice. The present study was to find a non-invasive way to differentiate these two categories of NAFLD via lipidomic analysis. Methods: Lipidomic analysis was used to determine the changes of lipid moieties in blood from 20 NAFL and 10 NASH patients with liver biopsy. Liver histology was evaluated after hematoxylin and eosin staining and Masson’s trichrome staining. The profile of lipid metabolites in correlation with steatosis, inflammation, hepatocellular necroptosis, fibrosis, and NAFLD activity score(NAS) was analyzed. Results: Compared with NAFL patients, NASH patients had higher degree of steatosis, ballooning degeneration, lobular inflammation. A total of 434 different lipid molecules were identified, which were mainly composed of various phospholipids and triacylglycerols. Many lipids, such as phosphatidylcholine(PC)(P-22:0/18:1), sphingomyelin(SM)(d14:0/18:0), SM(d14:0/24:0), SM(d14:0/22:0), phosphatidylethanolamine(PE)(18:0/22:5), PC(O-22:2/12:0), and PC(26:1/11:0) were elevated in the NASH group compared to those in the NAFL group. Specific analysis revealed an overall lipidomic profile shift from NAFL to NASH, and identified valuable lipid moieties, such as PCs [PC(14:0/18:2), PE(18:0/22:5) and PC(26:1/11:0)] or plasmalogens [PC(O-22:0/0:0), PC(O-18:0/0:0), PC(O-16:0/0:0)], which were significantly altered in NASH patients. In addition, PC(14:0/18:2), phosphatidic acid(18:2/24:4) were positively correlated with NAS;whereas PC(18:0/0:0) was correlated positively with fibrosis score. Conclusions: The present study revealed overall lipidomic profile shift from NAFL to NASH, identified valuable lipid moieties which may be non-invasive biomarkers in the categorization of NAFLD. The correlations between lipid moieties and NAS and fibrosis scores indicate that these lipid biomarkers may be used to predict the severity of the disease. | Zhong-Hua Wang Kenneth I Zheng Xiao-Dong Wang Jin Qiao Yang-Yang Li Li Zhang Ming-Hua Zheng Jian Wu | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 2 |
| 4 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 5 | Impacts of invasion by Dreissena polymorpha ( Pallas, 1771 ) on the performance of mae- roinvertebrate assessment tools for eutrophication pressure in lakes 显示文摘 | Atalah J Mary K Q Kenneth I | 2010 | Hydrobiotogia2010，654，1： | 1 |
| 6 | The Gelation and Crystallization of Amylopeetin 显示文摘 | Stephen G Ring Paul Colonna Kenneth J I' Anson | 1987 | Carbohydr Res1987，162，： | 1 |
| 7 | Specific Emitter Identification and Verification显示文摘 | Kenneth I Talhot Paul R Duley Martin H Hyatt | 2003 | Technology Review Journal2003，11，1： | 1 |
| 8 | Idiopathic granulomatous mastitis lesion mimicking inflamma- tory breast cancer显示文摘 | Martin A Nzegwu Kenneth A Agu Peace I Amaraegbulam | 2007 | CMAJ2007，176，13： | 1 |
| 9 | Specific emitter identiilcation (SEI) and classical parameter fusion technology显示文摘 | Kenneth I T Paul R D Martin H H | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，2： | 1 |
| 10 | Investigation of potential biosurfactant production among phytopathogenic corynebacteria and related soil microbes 显示文摘 | Juliana A David G C Kenneth I | 1981 | Current Microbiology1981，6，3： | 1 |
| 11 | Accuracy and precision of cone-beam computed tomography guided intensity modulated radiation therapy 显示文摘 | Sutton M W Fontenot J D Kenneth I I | 2014 | Pract Radiat Oncol2014，4，4： | 1 |
| 12 | Digoxin -like immunoreactive factors induce apoptosis in human acute T - cell lymphoblastic leukemia显示文摘 | Kenneth I Hassan MQ Fabian C | 2007 | Clin Chem2007，53，： | 1 |
| 13 | Fate of fumonisins during the production of flied tortilla chips 显示文摘 | Kenneth A V Stephen M P Filmore I M | 2001 | Journal of Agriculture Food Chemistry2001，49，6： | 1 |
| 14 | Specific investments in marketing relationships: Expropriation and bonding effects 显示文摘 | Rokkan Rokkan Aksel I Heide Jan B Wathne Kenneth H | 2003 | Journal of Marketing Research2003，40，2： | 1 |
| 15 | Natural radioactivity in cultivated land in the vicinity of a phosphate fertilizer plant in Nigeria 显示文摘 | Mark C O Kenneth K A Felicitas U I | 2012 | Radiation Physics and Chemistry2012，，81： | 1 |
| 16 | Efficient electrocatalytic detection of epinephrine at gold electrodes modified with self-assembled metallo-octacarboxyphthalocyanine complexes显示文摘 | Bolade O Agboola Kenneth I Ozoemena | 2008 | Electroanalysis2008，20，： | 1 |
| 17 | Endovascular treatment of hepatic artery thrombosis following liver transplantation显示文摘 | Ashish Singhal Kenneth Stokes Anthony Sebastian Harlan I Wright Vivek Kohli | 2010 | Transplant International2010，，3： | 1 |
| 18 | Maternal vitamin A nutritureandthe vitamin A contentof human milk显示文摘 | MARIORIE J HASKEL I KENNETH H | 1999 | Journal of Mammary Gland Biology and Neoplasia1999，14，3： | 1 |
| 19 | Evaluation of the impact of climate change on hydrology and water resources in Swaziland: Part I 显示文摘 | Jonathan I Matondo Graciana Peter Kenneth M Msibi | 2004 | Physics and Chemistry of the Earth2004，29，： | 1 |
| 20 | Evaluation of the impact of climate change on hydrology and water resources in Swaziland : Part II 显示文摘 | Jonathan I Matondo Graciana Peter Kenneth MMsibi | 2004 | Physics and Chemistry of the Earth2004，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员