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| 1 | Update on the natural history of intracranial atherosclerotic disease: A critical review显示文摘Intracranial atherosclerotic disease (ICAD) contributes to a significant number of ischemic strokes. There is debate in the recent literature concerning the impact of the location of stenosis in ICAD on outcome. Some reports have suggested that disease processes and outcomes vary by vessel location, potentially altering the natural history and indications for intervention. Here we have performed a comprehensive, critical review of the natural history of ICAD by vessel in an attempt to assess the differences in disease specific to each of the vascular territories. Our assessment concludes that only minor differences exist between patients with different vessels affected in vessel-specific ICAD. We have found that middle cerebral artery disease confers a lower mortality than vessel-specific ICAD in other intracranial vessels, asymptomatic disease follows a more benign course than symptomatic disease, andthat plaque progression or the detection of microemboli on transcranial Doppler may predict poor outcome. Given the expanding indications for treatment of ICAD and rapidly developing endovascular techniques to confront this disease, a thorough understanding of the natural history of ICAD aids the interventional neuroradiologist in determining when to treat and how to predict outcome in this patient population. | Ricardo J Komotar Christopher P Kellner Daniel M Raper Dorothea Strozyk Randall T Higashida Philip M Meyers | 2010 | World Journal of Radiology2010，2，5： | 8 |
| 2 | 直接光控晶闸管在脉冲电源上的应用显示文摘具有集成保护功能的直接光控晶闸管 (LTT)已得到了广泛应用。这种晶闸管是为高压直流输电(HVDC)而开发的。通过改进门极结构 ,光控晶闸管也可用于大功率脉冲电源上。由于采用了直接光触发 ,LTT特别适用于串联应用。 | J Przybilla R Keller U Kellner C Schneider H J Schulze F J Niedernostheide | 2002 | 电力电子技术2002，36，6： | 2 |
| 3 | Transposable elements significantly contributed to the core promoters in the human genome显示文摘Transposable elements(TEs) are major components of the human genome constituting at least half of it. More than half a century ago, Barbara McClintock and later Roy Britten and Eric Davidson have postulated that they might be major players in the host gene regulation. We have scanned a large amount of data produced by ENCODE project for active transcription binding sites(TFBSs) located in TE-originated parts of polymerase II promoters. In total, more than 35,000 promoters in six different tissues were analyzed and over 26,000 of them harbored TEs. Moreover, these TEs usually provide one or more of TFBSs in the host promoters, which resulted in more than 6% of active TFBSs in these regions located in the TE-originated sequences. Rewiring of transcription circuits played a major role in mammalian evolution and consequently increased their functional and morphological diversity. In this large-scale analysis, we have demonstrated that TEs contributed a large fraction of human TFBSs. Interestingly,these TFBSs usually act in a tissue-specific manner. Thus, our study clearly showed that TEs played a significant role in shaping expression pattern in mammals and humans in particular. Furthermore, since several TE families are still active in our genome,they continue to influence not only our genome architecture but also gene functioning in a broader sense. | Marten Kellner Wojciech Maka?owski | 2019 | Science China(Life Sciences)2019，62，4： | 2 |
| 4 | Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease显示文摘AIM: With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the fact whether reflux episodes causing complaints for a long time i.e., at least for one year are associated with metabolic changes in the lower esophageal sphincter, and if so,whether these may influence functional results achieved after anti-reflux surgery.METHODS: Between 1 January 2001 and 31 December 2002 we performed anti-reflux surgery on 79 patients.Muscle samples were taken from the lower esophageal sphincter (LES) in 33 patients during anti-reflux surgery.Inclusion criteria were: LES resting pressure below 10 mmHg and a marked, pH proven acid exposure to the esophagus of at least one year's duration, causing subjective complaints and requiring continuous proton pump inhibitor treatment. Control samples were obtained from muscle tissue in the gastroesophageal junction that had been removed from 17 patients undergoing gastric or esophageal resection. Metabolic and lysosomal enzyme activities and special protein concentrations 16 parameters in total were evaluated in tissue taken from control specimens and tissue taken from patients with GERD. The biochemical parameters of these intra-operative biopsies were used to correlate the results of anti-reflux operations (Visick I and II-III).RESULTS: In the reflux-type muscle, we found a significant increase of the energy-enzyme activities e.g., creatine kinase, lactate dehydrogenase, β-hydroxybutyrate dehydrogenase, and aspartate aminotransaminase-. The concentration of the structural protein S-100 and the myofibrillar protein troponin I were also significantly increased. Among lysosomal enzymes, we found that the activities of cathepsin B, tripeptidyl-peptidase I, dipeptidylpeptidase II, β-hexosaminidase B, β-mannosidase and β-galactosidase were significantly decreased as compared to the control LES muscles. By analyzing the activity values of the 9 patients in Visick groups Ⅱ and Ⅲ at two months post-surgery, we found a significant increase in the activity of the so-called energy-enzyme values and in the concentration of structural and myofibrillar proteins as compared to the rest of the reflux patients.CONCLUSION: Our results call attention to the metabolic changes that occurred in the LES muscles of reflux patients. The developing hypertrophy-like changes of LES muscles may be a reason for complaints after anti-reflux surgery, which consisted mainly of reports of persisting dysphagia. | Aron Altorjay Arpad Juhasz Viola Kellner Gellert Sohar Matyas Fekete Istvan Sonar | 2005 | World Journal of Gastroenterology2005，11，11： | 2 |
| 5 | Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma 显示文摘 | Kellner R Bukur J | 2002 | Proteomics2002，2，5： | 1 |
| 6 | Selective induction of apoptosis in leukemic B-lymphoid cells by a CD19-specific TRAIL fusion protein 显示文摘 | Stieglmaier J Bremer E Kellner C | 2008 | Cancer Immunol Immunother2008，57，2： | 1 |
| 7 | Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae显示文摘 | Johnston NJ De Azavedo JC Kellner JD | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 8 | Effect of WC grain size on the corrosion behavior of WC-Co based hardmetals in alkaline solutions显示文摘 | KELLNER F J J HILDEBRAND H VIRTANEN S | 2009 | International Journal of Refractory Metals & Hard Materials2009，27，4： | 1 |
| 9 | RecYcling technologies for the treatment of end of life printed circuit boards (PCBs)显示文摘 | GOOSEY M KELLNER R | 2003 | Circuit World2003，29，3： | 1 |
| 10 | Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance显示文摘 | Kellner R Lichtenfels R Atkins D | 2002 | Proteomics2002，2，12： | 1 |
| 11 | Culprit andvictim-DNA topoisomerase Ⅱ显示文摘 | Kellner U Sehested M Jensen PB | 2002 | Lancet Oncol2002，3，4： | 1 |
| 12 | Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral obstruction显示文摘 | Kellner D Chen J Richardson I | 2006 | J Urol2006，176，2： | 1 |
| 13 | Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy显示文摘 | Marmor MF Kellner U Lai TY | 2011 | Ophthalmology2011，118，2： | 1 |
| 14 | Comparison of different screening methods for chloroquine/hydroxychloroquine retinopathy: multifocal electroretinography, color vision, perimetry, oph- thalmoscopy, and fluorescein angiography显示文摘 | Missner S Kellner U | 2012 | Graefes Arch Clin Exp Ophthalmol2012，250，3： | 1 |
| 15 | Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral obstruction 显示文摘 | Kellner D Chen J Richardson I | 2006 | J Uol2006，176，2： | 1 |
| 16 | Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae 显示文摘 | Johnson NJ De Azavedo JC Kellner JD | 1998 | Antimicrob Agents Chemother1998，42，9： | 1 |
| 17 | Bau und Function der Haut显示文摘 | Kellner G | 1966 | Deutsche Zeitschrift fur Akupunktur1966，15，1： | 1 |
| 18 | Confirmation of organophosphorus pesticide residues in food applying gas chromatography/mass spectrometry with chemical ionization and pulsed positive negative detection显示文摘 | STAN H J KELLNER G | 1989 | Biomed Environ Mass Spectr1989，18，： | 1 |
| 19 | Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses显示文摘 | Lichtenfels R Kellner R Atkins D | 2003 | Biochim Biophys Acta2003，1646，12： | 1 |
| 20 | Human DNA-topoisomerases-diagnostic and therapeutic implications for cancer显示文摘 | Kellner U Rudolph p parwaresch R | 2000 | Onkologie2000，23，5： | 1 |
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