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| 1 | Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition显示文摘Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain unknown.This study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying mechanisms.The results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress levels.In addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with colitis.PEW also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria Proteobacteria.Taken together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition. | Lingyu Li Ning Qiu Yaqi Meng Chenyan Wang Yoshinori Mine Russell Keast Vincent Guyonnet | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 2 | Rubber toughening of plastics显示文摘 | Bucknall CB Clayton D Keast W | 1972 | Journal of materials science1972，7，12： | 1 |
| 3 | Visualization and immunohistochemical char- acterization of sympathetic and parasympathetic neurons in the male rat major pelvic ganglion显示文摘 | Keast JR | 1995 | Neuroscience1995，66，3： | 1 |
| 4 | Nerve growth factor,glial cell line-de- rived neurotrophic factor and neurturin prevent semaphorin 3A-medi- ated growth cone collapse in adult sensory neurons显示文摘 | Wanigasekara Y Keast JR | 2006 | Neuroscience2006，142，2： | 1 |
| 5 | Prediction of the stability of the Mn+1 AX, phases from first principles 显示文摘 | Keast V J Harris S Smith D K | 2009 | Phys Rev B2009，80，21： | 1 |
| 6 | Optimal pararmeters for multidimensional integration 显示文摘 | Keast P | 1973 | SIAM J Numer Anal1973，10，： | 1 |
| 7 | The case history of an elite ultra-endurance cyclist who developed chronic fatigue syndrome显示文摘 | Rowbottom DG Keast D Green S | 1998 | Med Sci Sports Exerc1998，30，9： | 1 |
| 8 | SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model显示文摘 | Lesley J. Murray Tinya J. Abrams Kelly R. Long Theresa J. Ngai Lisa M. Olson Weiru Hong Paul K. Keast Jacqueline A. Brassard Anne Marie O’Farrell Julie M. Cherrington Nancy K. Pryer | 2003 | Clinical and Experimental Metastasis2003，，8： | 1 |
| 9 | Depression of Plasma Glutamine Concentration After Exercise Stress and It s Possible Iinfluence on the Immunebn System显示文摘 | Keast D Arstein D | 1995 | Mecl J1995，8，： | 1 |
| 10 | Glutimine and macrophage function显示文摘 | Wallace Keast D | | 0，，： | 1 |
| 11 | Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain 显示文摘 | Kalous A Osborne PB Keast JR | 2009 | J Comp Neurol2009，513，6： | 1 |
| 12 | The haematological,biochemical and immunological profile of athletes suffering from the overtraining syndrome显示文摘 | Rowbottom DG Keast D Goodman C | 1995 | European Journal of Applied Physiology1995，70，： | 1 |
| 13 | Different substance P receptors are found on mucosal epithelial cells and submucous neurons of the guinea-pig small intestine 显示文摘 | Furness JB Costa M | 1985 | Naunyn Schmiedebergs Arch Pharmacol1985，329，4： | 1 |
| 14 | Effects of starvation and water quality on the purging process of farmed murray cod (Maccullochella peelii peelii)显示文摘 | PALMERI G TURCH1NI G M KEAST R | 2008 | Journal of Agricultural and Food Chemistry2008，56，19： | 1 |
| 15 | Foods, fortificants, and supplements:where do Americans get their nutrients显示文摘 | Fulgoni VL Keast DR Bailey RL | 2011 | JNutr2011，141，10： | 1 |
| 16 | Phytochemistry: ibuprofen-like activity in extra-virgin olive oil显示文摘 | Beauchamp G K Keast R S Morel D | 2005 | Nature2005，437，7055： | 1 |
| 17 | Dietary supplementuse is associated with higher intakes of minerals from foodsources显示文摘 | Bailey RL Fulgoni VR Keast DR | 2011 | Am J Clin Nutr2011，94，5： | 1 |
| 18 | The haematological, biochemical and immunological profile of athletes suffering fTom the overtraining syndrome显示文摘 | Rowbottom DG Keast D Goodman C | 1995 | Eur J Appl Physiol1995，70，6： | 1 |
| 19 | Measurement of Glomerular Filtration Rate with Technetium-99m DTPA: comparison of Plasma Clearance Techniques显示文摘 | Waller DG Keast CM Fleming JS | 1987 | J Nucl Med1987，28，： | 1 |
| 20 | Modification of the Bitterness of Caffe- ine显示文摘 | Russell S J Keast | 2008 | Food Quality and Preference2008，19，： | 1 |
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