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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Treatment strategy for patients with middle and lower third bile duct cancer 显示文摘 | Todoroki T Kawamoto T Koike N | 2001 | Br J Surg2001，88，3： | 1 |
| 3 | New local search methods for improving the lagrangian-relaxation-based unit commitment solution显示文摘 | Seki T Yamashita N Kawamoto K | 2010 | IEEE Trans on Power Systems2010，25，1： | 1 |
| 4 | Protec- tion of chickens from fowl cholera by vaccination with recombi- nant adhesive protein of Pasteurella multocida 显示文摘 | STHITMATEE N NUMEE S KAWAMOTO E | 2008 | Vaccine2008，26，19： | 1 |
| 5 | Contribution of bonemarrow-derived endothelial progenitor cells to neovascularization and astrogliosis following spinal cord injury显示文摘 | Kamei N Kwon S M Kawamoto A | 2012 | J Neurosci Res2012，90，12： | 1 |
| 6 | Production of γ-aminobutyric acid(GABA) by Lactobacillus paracasei isolated from traditional fermented foods 显示文摘 | Komatsuzaki N Shima J Kawamoto S | 2005 | Food Microbiol2005，22，6： | 1 |
| 7 | Using endosonography to assess the effects of neoadjuvant therapy in patients with advanced esophageal cancer显示文摘 | Hirata N Kawamoto K Ueyama T | 1997 | AJR Am J Roentgenol1997，169，： | 1 |
| 8 | Production of γ-aminobutyric acid (GABA) by Lactobacillus paracasei isolated from traditional fermented foods显示文摘 | KOMATSUZAKI N SHIMA J KAWAMOTO S | 2005 | Food Mierobiol2005，22，6： | 1 |
| 9 | Effects of pneumoperitoneum on cardiac autonomic nervous activity evaluated by heart rate variability analysis during sevoflurane,isoflurane,or propofol anesthesia 显示文摘 | Sato N Kawamoto M Yuge O | 2000 | Surg Endosc2000，14，4： | 1 |
| 10 | Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability 显示文摘 | Kuriyama H Kawamoto S Ishida N | 1997 | Biochem Biophys Res Commum1997，241，： | 1 |
| 11 | Prediction of reversible ischemia after revascularization: perfusion and metabolic studies with positron emission tomography 显示文摘 | Tamaki N Kawamoto M Tadmnra E | 2002 | Circulation2002，91，6： | 1 |
| 12 | A crogs-sectional analysis of quality of life in Japanese acne patients using the Japanese version of Skindex-16显示文摘 | Hayashi N Higaki Y Kawamoto K | 2004 | J Dermatol2004，31，12： | 1 |
| 13 | Retinoic acid-induced apoptosis of the CHP134 neuroblastoma cell line is associated with nuclear accumulation of p53 and is rescued by the GDNF/Ret signal显示文摘 | Takada N Isogai E Kawamoto T | 2001 | Med Pediatr Oncol2001，36，1： | 1 |
| 14 | Radical resection of hilar bile duct carcinoma and predictors of survival显示文摘 | Todoreki T Kawamoto T Koike N | 2000 | Br J Surg2000，87，3： | 1 |
| 15 | Activation of TGF - be-ta/ activin signalling resets the circadian clock through rapid in-duction of Decl transcripts 显示文摘 | Kon N Hirota T Kawamoto T | 2008 | Nat Cell Biol2008，10，12： | 1 |
| 16 | Association between obesity and polymorphisms in SEC16B,TMEM18,GNPDA2,BDNF,FAIM2 and MC4R in a Japanese population显示文摘 | Hotta K Nakamura M Nakamura T Matsuo T Nakata Y Kamohara S Miyatake N Kotani K Komatsu R Itoh N Mineo I Wada J Masuzaki H Yoneda M Nakajima A Funahashi T Miyazaki S Tokunaga K Kawamoto M Ueno T Hamaguchi K Tanaka K Yamada K Hanafusa T Oikawa S Yoshimatsu | | 0，，12： | 1 |
| 17 | Resuscitation of the viable but nonculturable state of Salmonella enterica serovar Oranienburg by recombinant resuscitation-promoting factor derived from Salmonella typhimurium strain LT2 显示文摘 | Panutdaporn N Kawamoto K Asakura H Makino SI | 2006 | FoodMicrobiol2006，106，3： | 1 |
| 18 | Preferential gen- eration of follicular B helper T cells from Foxp3-}- T cells in gut Peyer's patches 显示文摘 | Tsuji M Komatsu N Kawamoto S | 2009 | Science2009，323，： | 1 |
| 19 | Nerve growth factor combined with vascular endothelial growth factor enhances regeneration of bladder acel- lular matrix graft in spinal cord injury-induced neu- rogenic rat bladder显示文摘 | KIKUNO N KAWAMOTO K HIRATA H | 2009 | British Journal of Urology International2009，103，1： | 1 |
| 20 | Production of-aminobutyric acid(GABA)by Lactobacillus paracasei iso-lated from traditional fermented foods显示文摘 | KOMATSUZAKI N SHIMA J KAWAMOTO S | 2005 | Food Microbiology2005，22，6： | 1 |
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