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| 1 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 2 | Antibacterial activity of leaves and inter-nodal callus extracts of Mentha arvensis L显示文摘Objective:To determine the anti-bacterial efficacy of chloroform,ethanol,ethyl acetate and water extracts of inter-nodal and leaves derived calli extracts from Mentha arvensis(M.arvensis) against Salmonella typhi(S.typhi),Streptococcus pyogenes(S.pyogenes),Proteus vulgaris(P. vulgaris) and Bacillus subtilis(B.subtilis).Methods:The inter-nodal and leaves segments of M.arvensis were cut into 0.5-0.7 cm in length and cultured on Murashige and Skoog solid medium supplemented with 3%sucrose,gelled with 0.7%agar and different concentration of 2,4-Dichlorophenoxyacetie acid(2,4-D) either alone or in combinations.The preliminary phytochemical screening was performed by Brindha et al method.Antibacterial efficacy was performed by disc diffusion method and incubated for 24 h at 37℃.Results:Maximum percentage of callus formation(inter-nodal segments 84.3±0.78;leaves segments 93.8±1.27) was obtained on Murashige and Skoog’s basal medium supplemented with 3%sucrose and 1.5 mg/L of 2,4-D.The ethanol extracts of leaves derived calli showed the maximum bio-efficacy than other solvents.The leaves and stem derived calli extracts on Proteus sp.showed that the plants can be used in the treatment of urinary tract infection associated with Proteus sp.Through the bacterial efficacy studies,it is confirmed that the in vitro raised calli tissue was more effective compared to in vivo tissue.Conclusions:The bio-efficacy study confirmed that the calli mediated tissues showed the maximum zone of inhibition.The present study paved a protocol to establish high potential cell lines by in vitro culture. | Johnson M Wesely EG Kavitha MS Uma V | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 9 |
| 3 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 4 | Clinical profile of brucellosis from a tertiary care center in southern India显示文摘Objective:To highlight the spectrum of clinical manifestations,labs,complications,treatment and outcome of brucellosis.Methods:Retrospective study was conducted in Kasturba Medical College,Manipal University,Karnataka,India which included 68 confirmed cases of brucellosis from January 2006- April 2010.Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method(or) by testing the sera for Brucella agglutinins using the standard agglutination test(SAT).A titer of 1:320 or more was considered as significant.SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation.Results:Of the 68 patients,46(68%) were male and 22(32%) were female patients with age distribution of 9-75 years.Forty four(64.7%) had history of contact with unpasteurized dairy products or infected animals.Symptoms included fever(68,100%),myalgia(21,31%),musculoskeletal symptoms (23,34%),headache(16,24%),gastrointestinal symptoms(19,28%) and altered sensorium(3, 4%).Co-morbidities and associations included HIV positivity(2,3%),type 2 diabetes mellitus (13,19%),steroid therapy(3,4%) and HBsAg positivity(8,12%).Ten(15%) patients had cervical lymphadenopathy,4(6%) had splenic enlargement,6(7%) had hepatomegaly,19(28%) had hepatosplenomegaly and 2(3%) got meningeal signs.Anaemia was observed in 39(57.3%) cases,high erythrocyte sedimentation rate(ESR) was present in 55(80.8%) cases,leucocytosis in 10(14.7%),leucopenia in 10(14.7%),thrombocytopenia in 23(33.82%) and thrombocytosis in 2(2.94%) cases.Conclusions:In countries like India,where brucellosis and tuberculosis are endemic;rapid,sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy. | Vishwanath Sathyanarayanan Abdul Razak Kavitha Saravu Shastry Barkur Ananthakrishna Mukhyprana Prabhu M Vandana KE | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 3 |
| 5 | Synthesis and curing studies of PPG based telechelic urethane methacryllc macromonomers显示文摘 | Asha S K Thirumal M Kavitha A | 2005 | European Polymer Journal2005，41，1： | 1 |
| 6 | Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impair- ment,redox balance and Bel-2/Bax expression in experimental Par- kinson' s disease mice 显示文摘 | Kavitha M Nataraj J Essa MM | 2013 | Chem Biol Interact2013，206，2： | 1 |
| 7 | Synthesis and curing studies of PPG based teleehelie urethane methaerylic 显示文摘 | Asha S K Thirumal M Kavitha A | 2005 | European Polymer Journal2005，41，1： | 1 |
| 8 | A New Feature Set for Content Based Image Retrieval 显示文摘 | Rao M B Kavitha C H | 2013 | Information Communication and Embedded Systems2013，1，1： | 1 |
| 9 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 10 | Properties of an extracellular amylase purified from a Bacillus species显示文摘 | VATSALA M KAVITHA R | 2001 | World Microbiol Biotechnol2001，17，8： | 1 |
| 11 | Toxicity of organophosphates on morphology and locomotor behav- ior ha brine shrimp, Anemia salina 显示文摘 | Venkateswara Rao J Kavitha P Jakka N M | 2007 | Archives of Environ- mental Contamination and Toxicology2007，53，2： | 1 |
| 12 | Generation of Ag nanoparticles by PAMAM dendrimersand their size dependence on the aggregation behavior ofdendriraers 显示文摘 | KAVITHA M PARIDA M R PRASAD E | 2009 | Macromolecular Chemistry andPhysics2009，210，16： | 1 |
| 13 | Kinetic and isothermal studies on liquid - phase adsorption of 2,4 - dichlorophenol by palm pith carbon 显示文摘 | Sathishkumar M Binupriy A R Kavitha D | 2007 | Bioresource Technology2007，98，4： | 1 |
| 14 | Nested polymerase chain reaction on blood clots for gene encoding 56 kDa antigen and serology for the diagnosis of scrub typhus 显示文摘 | Prakash J Kavitha M Mathai E | 2011 | Indian J Med Microbiol2011，29，1： | 1 |
| 15 | Persistence behaviour of thiacloprid residues in/on green tea leaves, processed tea and tea infusion显示文摘 | Paramasivam M Kavitha J Chandrasekaran S | 2012 | Bulletin of Environmental Contamination and Toxicology2012，89，： | 1 |
| 16 | A new transferable digital cash protocol using proxy re-signature scheme 显示文摘 | Kavitha M Sunitha N R Amberker B B | 2011 | Communications in Computer and Information Science2011，250，： | 1 |
| 17 | Comparison of the remineralization potential of CPP -ACP and CPP-ACP with 900 ppm fluoride on eroded human enamel: an in situ study 显示文摘 | Srinivasan N Kavitha M Logmmthan SC | 2010 | Arch Oral Biol2010，55，7： | 1 |
| 18 | Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice显示文摘 | Kavitha M Nataraj J Essa MM | 2013 | Chem Biol Interact2013，206，2： | 1 |
| 19 | Outlier detection using support vector machine in wireless sensor network real time data 显示文摘 | Syed M M Kavitha T | 2011 | Intemational Journal of Soft Computing and Engineering2011，1，2： | 1 |
| 20 | Role of organic additives on zinc plating显示文摘 | Kavitha B Santhosh P Renukadevi M | | 0，，6： | 1 |
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