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| 1 | Global kinematics of tectonic plates and subduction zones since the late Paleozoic Era显示文摘Detailed global plate motion models that provide a continuous description of plate boundaries through time are an effective tool for exploring processes both at and below the Earth's surface. A new generation of numerical models of mantle dynamics pre-and post-Pangea timeframes requires global kinematic descriptions with full plate reconstructions extending into the Paleozoic(410 Ma). Current plate models that cover Paleozoic times are characterised by large plate speeds and trench migration rates because they assume that lowermost mantle structures are rigid and fixed through time. When used as a surface boundary constraint in geodynamic models, these plate reconstructions do not accurately reproduce the present-day structure of the lowermost mantle. Building upon previous work, we present a global plate motion model with continuously closing plate boundaries ranging from the early Devonian at 410 Ma to present day.We analyse the model in terms of surface kinematics and predicted lower mantle structure. The magnitude of global plate speeds has been greatly reduced in our reconstruction by modifying the evolution of the synthetic Panthalassa oceanic plates, implementing a Paleozoic reference frame independent of any geodynamic assumptions, and implementing revised models for the Paleozoic evolution of North and South China and the closure of the Rheic Ocean. Paleozoic(410-250 Ma) RMS plate speeds are on average ~8 cm/yr, which is comparable to Mesozoic-Cenozoic rates of ~6 cm/yr on average.Paleozoic global median values of trench migration trend from higher speeds(~2.5 cm/yr) in the late Devonian to rates closer to 0 cm/yr at the end of the Permian(~250 Ma), and during the Mesozoic-Cenozoic(250-0 Ma) generally cluster tightly around ~1.1 cm/yr. Plate motions are best constrained over the past 130 Myr and calculations of global trench convergence rates over this period indicate median rates range between 3.2 cm/yr and 12.4 cm/yr with a present day median rate estimated at~5 cm/yr. For Paleozoic times(410-251 Ma) our model results in median convergence rates largely~5 cm/yr. Globally,~90% of subduction zones modelled in our reconstruction are determined to be in a convergent regime for the period of 120-0 Ma. Over the full span of the model, from 410 Ma to 0 Ma,~93% of subduction zones are calculated to be convergent, and at least 85% of subduction zones are converging for 97% of modelled times. Our changes improve global plate and trench kinematics since the late Paleozoic and our reconstructions of the lowermost mantle structure challenge the proposed fixity of lower mantle structures, suggesting that the eastern margin of the African LLSVP margin has moved by as much as ~1450 km since late Permian times(260 Ma). The model of the plate-mantle system we present suggests that during the Permian Period, South China was proximal to the eastern margin of the African LLSVP and not the western margin of the Pacific LLSVP as previous thought. | Alexander Young Nicolas Flament Kayla Maloney Simon Williams Kara Matthews Sabin Zahirovic R.Dietmar Müller | 2019 | Geoscience Frontiers2019，10，3： | 10 |
| 2 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 3 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 4 | Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy显示文摘AIM To reduce readmissions and improve patient outcomes in cirrhotic patients through better understanding of readmission predictors.METHODS We performed a single-center retrospective study of patients admitted with decompensated cirrhosis from January 1, 2011 to December 31, 2013(n = 222). Primary outcomes were time to first readmission and 30-d readmission rate due to complications of cirrhosis. Clinical and demographic data were collected to help describe predictors of readmission, along with care coordination measures such as post-discharge status and outpatient follow-up. Univariate and multivariateanalyses were performed to describe variables associated with readmission.RESULTS One hundred thirty-two patients(59.4%) were readmitted at least once during the study period. Median time to first and second readmissions were 54 and 93 d, respectively. Thirty and 90-d readmission rates were 20.7 and 30.1 percent, respectively. Predictors of 30-d readmission included education level, hepatic encephalopathy at index, ALT more than upper normal limit and Medicare coverage. There were no statistically significant differences in readmission rates when stratified by discharge disposition, outpatient follow-up provider or time to first outpatient visit.CONCLUSION Readmissions are challenging aspect of care for cirrhotic patients and risk continues beyond 30 d. More initiatives are needed to develop enhanced, longitudinal post-discharge systems. | Siamak M Seraj Emily J Campbell Sarah K Argyropoulos Kara Wegermann Raymond T Chung James M Richter | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 5 | Decoding earth’s plate tectonic history using sparse geochemical data显示文摘Accurately mapping plate boundary types and locations through time is essential for understanding the evolution of the plate-mantle system and the exchange of material between the solid Earth and surface environments.However,the complexity of the Earth system and the cryptic nature of the geological record make it difficult to discriminate tectonic environments through deep time.Here we present a new method for identifying tectonic paleo-environments on Earth through a data mining approach using global geochemical data.We first fingerprint a variety of present-day tectonic environments utilising up to 136 geochemical data attributes in any available combination.A total of 38301 geochemical analyses from basalts aged from 5-0 Ma together with a well-established plate reconstruction model are used to construct a suite of discriminatory models for the first order tectonic environments of subduction and mid-ocean ridge as distinct from intraplate hotspot oceanic environments,identifying 41,35,and 39 key discriminatory geochemical attributes,respectively.After training and validation,our model is applied to a global geochemical database of 1547 basalt samples of unknown tectonic origin aged between 1000-410 Ma,a relatively ill-constrained period of Earth’s evolution following the breakup of the Rodinia supercontinent,producing 56 unique global tectonic environment predictions throughout the Neoproterozoic and Early Paleozoic.Predictions are used to discriminate between three alternative published Rodinia configuration models,identifying the model demonstrating the closest spatio-temporal consistency with the basalt record,and emphasizing the importance of integrating geochemical data into plate reconstructions.Our approach offers an extensible framework for constructing full-plate,deeptime reconstructions capable of assimilating a broad range of geochemical and geological observations,enabling next generation Earth system models. | Michael G.Tetley Zheng-Xiang Li Kara J.Matthews Simon E.Williams R.Dietmar Müller | 2020 | Geoscience Frontiers2020，11，1： | 2 |
| 6 | Multiple signaling pathways are involved in the regulation of IGF-1 receptor inhibition of PTEN enhanced apoptosis显示文摘 | Wu Y Karas M Duponl J | 2004 | Growth Horm IGFRes2004，14，1： | 1 |
| 7 | The protective effects of estrogen on the cardiovascularsystem显示文摘 | Mendelsohn M E Karas R H | 1999 | NEnglJ Med1999，340，23： | 1 |
| 8 | Sleep disturbances and suicidal behavior in patients with major depression显示文摘 | Agargun MY Kara H Solmaz M | 1997 | Journal of Clinical Psychiatry1997，58，： | 1 |
| 9 | Performance of infrared mat fix-assisted laser desorption/ionization mass spectrometry with lasers emitting in the 3 mm wavelength range显示文摘 | BERKENKAMP S MENZEL C KARAS M | 1997 | Rapid Communications in Mass Spectrometry1997，11，13： | 1 |
| 10 | Is cold therapy really efficient after knee arthroplasty显示文摘 | Kuyucu E Btilbul M Kara A | 2015 | Ann Med Surg (Lond)2015，4，4： | 1 |
| 11 | Heavy met- als in soil,vegetables and fruits in the endemic upper gastroin- testinal cancer region of Turkey显示文摘 | TURKDOGAN M K KILICEL F KARA K | 2003 | Environmental Toxicology and Pharmacology2003，13，3： | 1 |
| 12 | Pet-cutaneous drainage for treatment of infected pancreatic pseudocysts显示文摘 | Cantasdemir M Kara B Kantarci F | 2003 | South Med J2003，96，2： | 1 |
| 13 | Molecular and cellular basis of cardiovascular gender differences显示文摘 | Mendelsohn M E Karas R H | 2005 | Science2005，308，5728： | 1 |
| 14 | Activation of subtilin precursors by Bacillus subtilis extracellular serine proteases subtilisin (AprE), WprA, and Vpr 显示文摘 | Corvey C Stein T Düsterhus S Karas M Entian K-D | 2003 | Biochem Biophys Res Commun2003，304，： | 1 |
| 15 | Diagnostic implications of telomerase activity in pleural effusions显示文摘 | Dikmen G Dikmen E Kara M | | 0，，03： | 1 |
| 16 | Estrogen inhibits the vascolar injury response in estrogen receptor alpha-deficient mice显示文摘 | Iarati MD Karas RH Aronovitz M | 1997 | Nat Med1997，3，5： | 1 |
| 17 | Effect of education on self - efficacy of Turkish pa- tients with chronic obstructive pulmonary disease 显示文摘 | Kara M Asti T | 2004 | Patient Educ Couns2004，55，1： | 1 |
| 18 | Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differventiation in HL-60 leukemic cells 显示文摘 | Amir H Karas M Giat J | 1993 | Nutr Cancer1993，33，1： | 1 |
| 19 | Predisposing factors fordelirium in the surgical intensive care unit 显示文摘 | ALDEMIR M OZEN S KARA I H | 2001 | Crit Care2001，5，： | 1 |
| 20 | The impacts of EU CO2 emission trading on electricity markets and electricity consumers in Finland 显示文摘 | Kara M Syri S Lehtila A Helynen S Kekkonen V Ruska M Forsstrom J | 2006 | Energy Economics2006，2，30： | 1 |
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